Bisphosphonates and Osteonecrosis of Jaws

Intricate Assessment and Evaluation of Dental Implants in Patients on Bisphosphonate Therapy: A Retrospective Analysis

“…Under the action of this strong acid, demineralization of the bone matrix and organic components takes place along with increased release of bone inductive proteins [bone morphogenetic proteins (BMPs) and insulin-like growth factors], which further promote differentiation of osteoblasts and new osteoid secreti. 11 When patients suffering from some kind of malignancies and bone diseases, such as cancer, Paget disease, and osteoporosis are treated with BP therapy, there is disturbance in the normal biological action of osteoclasts. There is loss of normal ruffled border of osteoclasts in response to BP reaction with osteoclasts, further causing a retraction from the bone's surface followed by its death.…”

Bisphosphonate-Related Osteonecrosis of the Jaw and Dental Implants

“…This strong acid demineralizes the bone matrix and organic components, and meanwhile increased release of bone inductive proteins (BMPs and insulin like growth factors) take place, which promote differentiation of osteoblasts and new osteoid secreti (1). For patients who are treated with bisphosphonates for some bone diseases such as cancer, Paget disease and osteoporosis; this normal biological action of osteoclasts is disturbed by this medication.…”