Bisphosphonates enhance bacterial adhesion and biofilm formation on bone hydroxyapatite

Kos, Marcin; Junka, Adam; Smutnicka, Danuta; Szymczyk, Patrycja; Gluza, Karolina; Bartoszewicz, Marzenna

doi:10.1016/j.jcms.2015.04.018

Cited by 23 publications

(19 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…P. aeruginosa ATCC 14452 and S. aureus ATCC 6538 reference strains were used for the experiments. Their ability to form biofilms on HA disks was confirmed in our previous studies, so here we simply used SEM technique for this purpose [ Supporting Information Figure S2].…”

Section: Resultsmentioning

confidence: 96%

Application of bacterial cellulose experimental dressings saturated with gentamycin for management of bone biofilm in vitro and ex vivo

et al. 2019

Self Cite

View full text Add to dashboard Cite

Bacterial cellulose is one of the most promising polymers of recent years. Herein, we present a possibility of BC application as a carrier of gentamycin antibiotic for the treatment and prevention of bone infections. We have shown that BC saturated with gentamycin significantly reduces the level of biofilm‐forming bone pathogens, namely Staphylococcus aureus and Pseudomonas aeruginosa, and displays very low cytotoxicity in vitro against osteoblast cell cultures. Another beneficial feature of our prototype dressing is prolonged release of gentamycin, which provides efficient protection from microbial contamination and subsequent infection. Moreover, it seems that bacterial cellulose (BC) alone without any antimicrobial added, may serve as a barrier by significantly hampering the ability of the pathogen to penetrate to the bone structure. Therefore, a gentamycin‐saturated BC dressing may be considered as a possible alternative for gentamycin collagen sponge broadly used in clinical setting. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:30–37, 2020.

show abstract

Section: Resultsmentioning

confidence: 96%

Application of bacterial cellulose experimental dressings saturated with gentamycin for management of bone biofilm in vitro and ex vivo

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…found that bisphosphonate-loaded titanium modified with Ca-ion implantation inhibited adhesion of P. gingivalis without toxic effects on osteoblast cells in vitro. Kos et al (2015), however, found both decreases and increases in S. mutans, S.aureus and P. aeroginosa on bisphosphonateloaded hydroxyapatite (HA), depending on the growth conditions. It is currently unclear how bisphosphonates and bacterial cells interact 30,35) .…”

Section: Drug-loaded Surfacesmentioning

confidence: 99%

“…Kos et al (2015), however, found both decreases and increases in S. mutans, S.aureus and P. aeroginosa on bisphosphonateloaded hydroxyapatite (HA), depending on the growth conditions. It is currently unclear how bisphosphonates and bacterial cells interact 30,35) . Another drawback of active-release antibiotic surfaces is the risk of generating cell toxicity or possible impairment of osteogenic activity.…”

Section: Drug-loaded Surfacesmentioning

confidence: 99%

Antimicrobial dental implant functionalization strategies —A systematic review

Grischke

Eberhard

Stiesch

2016

Dental Materials Journal

View full text Add to dashboard Cite

“…This results in a decreased bone turnover, with hypermineralization (target of the therapeutic use) and bone hypovascularization. Combination of a compact and avascular bone is believed to result in osteonecrosis by a mechanism of ischemia and secondary infection …”

Section: Introductionmentioning

confidence: 99%

Resection and microvascular reconstruction of bisphosphonate‐related osteonecrosis of the jaw: The role of microvascular reconstruction

et al. 2016

View full text Add to dashboard Cite

Complication rates after free flap microvascular reconstruction in BRONJ seem acceptable. Nonunion is relatively rare and should not be the sole reason to recommend against free flap reconstruction. A randomized clinical trial would help clarify the role of this procedure in refractory BRONJ; however, we believe that segmental resection and microvascular reconstruction is a viable option in select cases of BRONJ. © 2016 Wiley Periodicals, Inc. Head Neck 38:1278-1285, 2016.

show abstract

Bisphosphonates enhance bacterial adhesion and biofilm formation on bone hydroxyapatite

Cited by 23 publications

References 24 publications

Application of bacterial cellulose experimental dressings saturated with gentamycin for management of bone biofilm in vitro and ex vivo

Application of bacterial cellulose experimental dressings saturated with gentamycin for management of bone biofilm in vitro and ex vivo

Antimicrobial dental implant functionalization strategies —A systematic review

Resection and microvascular reconstruction of bisphosphonate‐related osteonecrosis of the jaw: The role of microvascular reconstruction

Contact Info

Product

Resources

About