Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque

Bailey, Denis M.; Degrazia, C. G.; Hoff, Stephanie J.; Schulenberg, P. L.; O'Connor, John R.; Paris, Donald A.; Slee, Andrew M.

doi:10.1021/jm00377a014

Cited by 65 publications

(46 citation statements)

References 2 publications

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“…In earlier studies, the MICs of OCT and CHG against a variety of test bacteria were quite similar (2,20). In this study, the bactericidal activity of OCT was superior to that of CHG, especially against Staphylococcus aureus and Streptococcus pyogenes.…”

Section: Resultssupporting

confidence: 57%

“…Octenidine hydrochloride (OCT) ( (2). Previous studies with this compound have shown it to be effective in inhibiting the growth of plaqueforming bacteria (16,20,21) and in reducing development of plaque in both experimental animals (6,16) and humans (13).…”

mentioning

confidence: 99%

“…Selection of OCT for this study was based on earlier studies which showed that the compound exhibited broadspectrum antimicrobial activity as measured by MICs against a variety of gram-positive and gram-negative bacteria (2). This activity was comparable to that exhibited by chlorhexidine gluconate (CHG) (Fig.…”

mentioning

confidence: 99%

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Microbicidal activity of octenidine hydrochloride, a new alkanediylbis[pyridine] germicidal agent

Sedlock¹,

Bailey²

1985

Antimicrob Agents Chemother

106

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The potential of octenidine hydrochloride (WIN 41464-2) as a topical microbicide was measured both by in vitro death kinetics and reductions in numbers of bacteria on the skin of cynomolgus monkeys. Semilogarithmic survial curves were plotted to measure the microbicidal activity of various concentrations of octenidine against Staphylococcus aureus. The microbicidal activity of octenidine was also determined for Staphylococcus epidermidis, Proteus mirabilis, Streptococcus pyogenes, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens, and Candida albicans. Death rates for the same microbial strains were compared with those obtained by using chlorhexidine gluconate. Octenidine concentrations of <1.5 ,LM (0.94 ,ug/ml) caused a greater than 99% reduction of each microbial population within 15 min. Staphylococcus epidermidis was the most susceptible of the test organisms, and E. coli and C. albicans were the least susceptible. Octenidine was more active than chlorhexidine against each test strain. Skin-degerming activities of aqueous and formulated octenidine and formulated chlorhexidine were compared in single and multiple applications of these agents to the hand and foot surfaces of monkeys by using a glove-juice extraction procedure to measure the skin microflora. Aqueous octenidine, at a concentration of 0.2 to 1.6% reduced resident microflora populations from 90 to 99.98%, depending on the concentration and number of applications. Octenidine formulated at 2% in a surfactant-based vehicle exhibited significantly better skin-degerming activity than did either a nonmedicated vehicle or the Hibiclens brand of 4% chlorhexidine gluconate.

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Section: Resultssupporting

confidence: 57%

mentioning

confidence: 99%

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Microbicidal activity of octenidine hydrochloride, a new alkanediylbis[pyridine] germicidal agent

Sedlock¹,

Bailey²

1985

Antimicrob Agents Chemother

106

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“…Due to its unspecific, strong absorption and interaction with cell wall and cell membrane structures, octenidine has a broad antimicrobial spectrum against Grampositive and Gram-negative bacteria including MRSA [1] [84,85] . Octenidine is superior to chlorhexidine and alexidine as an inhibitor of plaque-forming enzymes of Streptococcus mutans [84] .…”

Section: Spectrum Of Activitymentioning

confidence: 99%

Octenidine Dihydrochloride, a Modern Antiseptic for Skin, Mucous Membranes and Wounds

Hübner

Siebert²,

Krämer³

2010

Skin Pharmacol Physiol

204

132

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Octenidine dihydrochloride (octenidine) was introduced for skin, mucous membrane and wound antisepsis more than 20 years ago. Until now, a wealth of knowledge has been gained, including in vitro and animal studies on efficacy, tolerance, safety and clinical experience both from case reports and prospective controlled trials. Nowadays, octenidine is an established antiseptic in a large field of applications and represents an alternative to older substances such as chlorhexidine, polyvidone-iodine or triclosan. The review is based on the current literature and unpublished original data as well.

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“…Therefore, there is a need for an effective disinfectant that can eliminate listerial biofilms in the presence of organic matter at a wide range of temperatures. Octenidine hydrochloride (OH) is a positively charged bispyridinamine that exhibits antimicrobial activity against plaque-producing organisms, such as Streptococcus mutans and Streptococcus sanguis (5). Toxicity studies with a variety of species have shown that OH is not absorbed through mucous membranes and the gastrointestinal tract, and there have been no reports of carcinogenicity, genotoxicity, or mutagenicity of this compound (17,19,29).…”

mentioning

confidence: 99%

Effect of Octenidine Hydrochloride on Planktonic Cells and Biofilms of Listeria monocytogenes

Amalaradjou¹,

Norris

Venkitanarayanan³

2009

Appl Environ Microbiol

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Listeria monocytogenes is a food-borne pathogen capable of forming biofilms and persisting in food processing environments for extended periods of time, thereby potentially contaminating foods. The efficacy of octenidine hydrochloride (OH) for inactivating planktonic cells and preformed biofilms of L. monocytogenes was investigated at 37, 21, 8, and 4°C in the presence and absence of organic matter (rehydrated nonfat dry milk). OH rapidly killed planktonic cells and biofilms of L. monocytogenes at all four temperatures. Moreover, OH was equally effective in killing L. monocytogenes biofilms on polystyrene and stainless steel matrices in the presence and absence of organic matter. The results underscore OH's ability to prevent establishment of L. monocytogenes biofilms by rapidly killing planktonic cells and to eliminate preformed biofilms, thus suggesting that it could be used as a disinfectant to prevent L. monocytogenes from persisting in food processing environments.Listeria monocytogenes is a major bacterial pathogen (2), accounting for approximately 28% of the deaths resulting from food-borne illnesses in the United States (22). It is widespread in nature and occurs in soil, vegetation, fecal matter, sewage, water, and animal feed (14). Because it is ubiquitous, L. monocytogenes is frequently isolated from foods and food processing environments (13, 23), thereby presenting a significant challenge to the food industry. Several studies have shown that L. monocytogenes is capable of adhering to food contact surfaces, such as glass, stainless steel, rubber, and polystyrene (6,11,28). Upon attachment to such surfaces, L. monocytogenes establishes biofilms and persists for long periods of time in the food processing environment (18,30). This potentially poses a food safety hazard since biofilms are an important source of contamination of food products that come into contact with them. In addition, biofilms also protect the underlying bacteria from desiccation, antimicrobials, and sanitizing agents (7, 16). Thus, eradication of L. monocytogenes biofilms in processing plants is critical for improving food safety.When problems with persistent L. monocytogenes are encountered in food processing facilities, plant hygiene and sanitation are emphasized (31). This involves preventing the establishment of L. monocytogenes biofilms in the food processing environment and reducing contamination of product contact surfaces. A variety of cleaners and disinfectants, including quaternary ammonium compounds and hypochlorite, have been evaluated for this purpose (20). Although these compounds are approved by the Food and Drug Administration for use as disinfectants in processing plants, they are not effective in killing L. monocytogenes (24,25), especially in the presence of soil or organic matter and at low temperatures. Therefore, there is a need for an effective disinfectant that can eliminate listerial biofilms in the presence of organic matter at a wide range of temperatures. Octenidine hydrochloride (OH) is a positively char...

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Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque

Cited by 65 publications

References 2 publications

Microbicidal activity of octenidine hydrochloride, a new alkanediylbis[pyridine] germicidal agent

Microbicidal activity of octenidine hydrochloride, a new alkanediylbis[pyridine] germicidal agent

Octenidine Dihydrochloride, a Modern Antiseptic for Skin, Mucous Membranes and Wounds

Effect of Octenidine Hydrochloride on Planktonic Cells and Biofilms of Listeria monocytogenes

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