1998
DOI: 10.1152/jn.1998.80.2.572
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Bistability in Spinal Motoneurons In Vivo: Systematic Variations in Rhythmic Firing Patterns

Abstract: In the presence of the monoamines serotonin and norepinephrine, spinal motoneurons can exhibit bistable behavior, in which a brief period of excitatory input evokes prolonged self-sustained firing. A brief inhibitory input returns the cell to the quiescent state. To determine whether motoneurons differ in their capacity for bistable behavior, intracellular recordings were obtained in the decerebrate cat preparation. To enhance the likelihood of encountering bistable behavior, the noradrenergic alpha1 agonist m… Show more

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Cited by 240 publications
(267 citation statements)
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“…We found no evidence for plateau potentials or any other long-lasting cellular bistability that could explain their persistent activity during swimming (Hounsgaard and Kiehn, 1989;Kiehn, 1991;Fraser and MacVicar, 1996;Marder and Calabrese, 1996;Lee and Heckman, 1998;Perrier and Tresch, 2005). Plateau responses generated by calcium activated nonspecific (CAN) currents have been widely implicated in the generation of prolonged responses, including those in lamprey reticulospinal neurons (Viana Di Prisco et al, 1997, 2000.…”
Section: Discussionmentioning
confidence: 83%
See 1 more Smart Citation
“…We found no evidence for plateau potentials or any other long-lasting cellular bistability that could explain their persistent activity during swimming (Hounsgaard and Kiehn, 1989;Kiehn, 1991;Fraser and MacVicar, 1996;Marder and Calabrese, 1996;Lee and Heckman, 1998;Perrier and Tresch, 2005). Plateau responses generated by calcium activated nonspecific (CAN) currents have been widely implicated in the generation of prolonged responses, including those in lamprey reticulospinal neurons (Viana Di Prisco et al, 1997, 2000.…”
Section: Discussionmentioning
confidence: 83%
“…In bistability hypotheses, activity results from the intrinsic membrane properties of specialized neurons, which generate prolonged responses to brief excitation. There is direct evidence from studies in a wide range of such neurons that brief excitation can lead to plateau depolarizations and prolonged firing (Hounsgaard and Kiehn, 1989;Kiehn, 1991;Fraser and MacVicar, 1996;Marder and Calabrese, 1996;Lee and Heckman, 1998;Perrier and Tresch, 2005). In reverberation hypotheses, activity instead persists because neurons in a network feed excitation back onto each other (Lorente de No, 1938;Hebb, 1949;Durstewitz et al, 2000;Seung et al, 2000;Wang, 2001;Koulakov et al, 2002).…”
Section: Introductionmentioning
confidence: 99%
“…Motoneurons can produce plateau potentials that amplify and sustain their motor output (Bennett et al 1998a,b;Hounsgaard and Kiehn 1989;Hultborn 2002;Kiehn and Eken 1997;Lee and Heckman 1998b;Schwindt and Crill 1982). That is, in motoneurons there are voltage-dependent persistent inward currents (PICs) that are regeneratively activated once the membrane is depolarized beyond a critical threshold (about Ϫ45 to Ϫ55 mV) by a brief stimulus (Ͻ1 s).…”
Section: Introductionmentioning
confidence: 99%
“…One striking example is the development of plateau potentials in motoneurons. Through persistent inward currents, the relationship between input current and firing frequency becomes nonlinear and motoneurons can sustain firing for prolonged periods, outlasting any excitatory inputs (3,27,35,44,46,48). Because it is not feasible to perform intracellular motoneurons recordings in able-bodied humans, there is only indirect evidence suggesting the presence of sustained motoneuron firing associated with plateau potentials in humans (8, 9, 16, 18, 26, 31, 41, 43; for review see 42).…”
mentioning
confidence: 99%