Bit1 is an essential regulator of myogenic differentiation

Griffiths, Genevieve S.; Doe, Jinger; Jijiwa, Mayumi; Ry, Pam Van; Cruz, Vivian; Vega, Michelle de la; Ramos, Joe W.; Burkin, Dean J.; Matter, Michelle L.

doi:10.1242/dev.125765

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mitochondrial Bcl-2 inhibitor of transcription 1 (Bit1) was shown to be an essential mediator of muscle differentiation. Bit1-null mice exhibit a smaller muscle cross-sectional area, and primary myoblasts isolated from this model mice, with barely detectable Bcl-2, instead show higher caspase-3 activity and premature onset of myogenic differentiation (Griffiths et al, 2015). In addition to Bit1, Bcl-2 levels are regulated by mitogen-activated protein kinase (MAPK) signaling, and its effect on Bcl-2 is associated with skeletal muscle regeneration.…”

Section: Apoptosis and Myogenic Differentiationmentioning

confidence: 97%

Mitochondrial stress response and myogenic differentiation

Lin,

Sun,

Zhang

et al. 2024

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Regeneration and repair are prerequisites for maintaining effective function of skeletal muscle under high energy demands, and myogenic differentiation is one of the key steps in the regeneration and repair process. A striking feature of the process of myogenic differentiation is the alteration of mitochondria in number and function. Mitochondrial dysfunction can activate a number of transcriptional, translational and post-translational programmes and pathways to maintain cellular homeostasis under different types and degrees of stress, either through its own signaling or through constant signaling interactions with the nucleus and cytoplasm, a process known as the mitochondrial stress responses (MSRs). It is now believed that mitochondrial dysfunction is closely associated with a variety of muscle diseases caused by reduced levels of myogenic differentiation, suggesting the possibility that MSRs are involved in messaging during myogenic differentiation. Also, MSRs may be involved in myogenesis by promoting bioenergetic remodeling and assisting myoblast survival during myogenic differentiation. In this review, we will take MSRs as an entry point to explore its concrete regulatory mechanisms during myogenic differentiation, with a perspective to provide a theoretical basis for the treatment and repair of related muscle diseases.

show abstract

Section: Apoptosis and Myogenic Differentiationmentioning

confidence: 97%