Bitemporal independent 3-Hz spike-and-waves in adult patient with idiopathic generalized epilepsy and Graves disease

Broutian, A. G.; Dolgova, Snezhana; Belyakova-Bodina, A. I.; Абрамова, А. А.; Lukianova, Anastasia; Noskova, T. Yu.

doi:10.1016/j.cnp.2020.09.001

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…Furthermore, the case also demonstrated bitemporal independent lateralized 3-Hz spike-and-wave activity. 10 The observed EEG alterations in individuals with hyperthyroidism, such as diffuse, bilateral, or regional slowing, heightened fast activity, elevated alpha-rhythm frequency, and modified responsiveness to photic stimulation, suggest a potential interaction between thyroid dysfunction and thalamocortical network oscillations in idiopathic generalized epilepsy. This interaction may ultimately lead to a decreased seizure threshold and the initiation of epileptic episodes.…”

Section: The Role Of Thyroid Hormones In Cns and Epilepsy Thyroid Hor...mentioning

confidence: 99%

Hormonal Changes in Women with Epilepsy

Li,

Zhang,

Fang

2024

NDT

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Epilepsy is a prevalent neurological disorder among women globally, often requiring long-term treatment. Hormonal fluctuations in women with epilepsy (WWE) can have reciprocal effects on epilepsy and antiseizure medications (ASMs), posing significant challenges for WWE. Notably, WWE commonly experience endocrine alterations such as thyroid dysfunctions, low bone metabolism, and reproductive hormone irregularities. On the one hand, the presence of hormones in women with epilepsy affects their susceptibility to epilepsy as well as the metabolism of antiseizure medications in various ways. On the other hand, epilepsy itself and the use of antiseizure medications impact the production, secretion, and metabolism of hormones, resulting in low fertility, increased risk of pregnancy complications, negative offspring outcomes, and so on. In order to develop more precise treatment strategies in the future, it is necessary to comprehend the explicit relationships between hormones, epilepsy, and antiseizure medications, as well as to elucidate the currently known mechanisms underlying these interactions.

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Section: The Role Of Thyroid Hormones In Cns and Epilepsy Thyroid Hor...mentioning

confidence: 99%

Hormonal Changes in Women with Epilepsy

Li,

Zhang,

Fang

2024

NDT

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“…4 GTCS is characterized by muscle contractions and sudden loss of consciousness, 5,6 with generalized spikewave discharge. 7,8 Moreover, in patients with GTCS, widespread abnormal functional activity has been detected throughout the brain, 9 and it has been suggested that both primary and high-order brain networks are involved. 10,11 Most GTCSs can be effectively controlled by antiseizure medications (ASMs).…”

Section: Introductionmentioning

confidence: 99%

“…Generalized tonic–clonic seizures (GTCS) is a type of epilepsy and accounts for 20%–55% of all epilepsies 4 . GTCS is characterized by muscle contractions and sudden loss of consciousness, 5,6 with generalized spike–wave discharge 7,8 …”

Section: Introductionmentioning

confidence: 99%

Functional and structural networks decoupling in generalized tonic–clonic seizures and its reorganization by drugs

Pei

Wei

et al. 2023

Epilepsia Open

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ObjectiveTo investigate potential functional and structural large‐scale network disturbances in untreated patients with generalized tonic–clonic seizures (GTCS) and the effects of antiseizure drugs.MethodsIn this study, 41 patients with GTCS, comprising 21 untreated patients and 20 patients who received antiseizure medications (ASMs), and 29 healthy controls were recruited to construct large‐scale brain networks based on resting‐state functional magnetic resonance imaging and diffusion tensor imaging. Structural and functional connectivity and network‐level weighted correlation probability (NWCP) were further investigated to identify network features that corresponded to response to ASMs.ResultsUntreated patients showed more extensive enhancement of functional and structural connections than controls. Specifically, we observed abnormally enhanced connections between the default mode network (DMN) and the frontal–parietal network. In addition, treated patients showed similar functional connection strength to that of the control group. However, all patients exhibited similar structural network alterations. Moreover, the NWCP value was lower for connections within the DMN and between the DMN and other networks in the untreated patients; receiving ASMs could reverse this pattern.SignificanceOur study identified alterations in structural and functional connectivity in patients with GTCS. The influence of ASMs may be more noticeable within the functional network; moreover, abnormalities in both the functional and structural coupling state may be improved by ASM treatment. Therefore, the coupling state of structural and functional connectivity may be used as an indicator of the efficacy of ASMs.

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“…Generalized tonic-clonic seizures (GTCS) is a type of epilepsy characterized by muscle contractions, sudden loss of consciousness (Jallon & Latour, 2005; Marini, King, Archer, Newton, & Berkovic, 2003), with generalized spike-wave discharge(GSWD) (Broutian et al, 2020;Li, Chen, & Huang, 2020). Until now, antiepileptic drugs (AEDs) are common treatments for epilepsy.…”

Section: Introductionmentioning

confidence: 99%

Functional and Structural Networks Decoupling in GTCS and Its Reorganization by Drugs

Pei

Liu

et al. 2022

Preprint

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Objective:The present study aims to investigate the potential disturbance of functional and structural large-scale networks in drug-naive patients with generalized tonic-clonic seizures (GTCS) and the effects of drugs-receiving.Methods:In this study, 41 patients with GTCS, including 21 drug-naive patients and 20 patients with antiepileptic drugs (AEDs), and 29 healthy controls were recruited to construct large-scale brain networks based on the resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor image (DTI). The structural and functional connectivity and the coupling between structure and function were further investigated to identify the network features that responded to drugs.Results:Drug-naive patients showed extensively enhanced functional and structural connections compared with controls. Especially, abnormally enhanced connections between the default mode network (DMN) and the frontal parietal network (FPN) were observed. Besides, drug-receiving patients showed similar functional connection strength to that of the control group. However, drug-receiving and drug-naive patients demonstrated similar alterations in the structural network. Moreover, the structural and functional coupling was decreased in connections within DMN and DMN with other networks, and drug-receiving could reverse the decrease.Significance:These findings identified the pattern alteration of structural and functional connectivity in GTCS patients. AEDs treatment benefit for the seizures might originate from the effects of the functional network rather than the structural network. However, it can improve the abnormal brain network by affecting the coupling relationship. The coupling of structural and functional connectivity might be used to evaluate the efficacy of AEDs.

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Bitemporal independent 3-Hz spike-and-waves in adult patient with idiopathic generalized epilepsy and Graves disease

Cited by 5 publications

References 6 publications

Hormonal Changes in Women with Epilepsy

Hormonal Changes in Women with Epilepsy

Functional and structural networks decoupling in generalized tonic–clonic seizures and its reorganization by drugs

Functional and Structural Networks Decoupling in GTCS and Its Reorganization by Drugs

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