Abstract:Bitter taste receptors (TAS2Rs) serve an important function during evolution. They are designed to detect toxic plant metabolites before ingestion. With respect to bitter taste receptors the genetic repertoire of animal species is highly diverse reflecting the species differences in their metabolic requirements, the variety of habitats and evolutionary history. Over the recent years, an incredible amount of data on human bitter taste receptor pharmacology, biochemistry and structural features has accumulated. … Show more
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