Bixafen causes cardiac toxicity in zebrafish (Danio rerio) embryos

Yuan, Mingrui; Li, Wenhua; Xiao, Peng

doi:10.1007/s11356-021-13238-5

Cited by 18 publications

(6 citation statements)

References 63 publications

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“…The same authors also showed that pre-existing mitochondrial defects, such as partial SDH dysfunction, increased the susceptibility to SDHIs after several days of exposure [4]. Other recent reports revealed neurodevelopmental defects in zebrafish mode exposure of embryos to Bixafen or Boscalid a few hours post-fertilization [5,6] as severe cardiac toxicity [7]. Chronic exposures (28 days) of adult zebrafish led to alte in carbohydrate and lipid metabolism, and induced damage in the kidneys and t [8].…”

Section: Introductionmentioning

confidence: 86%

“…Other recent reports revealed neurodevelopmental defects in zebrafish models after exposure of embryos to Bixafen or Boscalid a few hours post-fertilization [ 5 , 6 ] as well as severe cardiac toxicity [ 7 ]. Chronic exposures (28 days) of adult zebrafish led to alterations in carbohydrate and lipid metabolism, and induced damage in the kidneys and the liver [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Know both compounds are readily absorbed after oral administration (83% and 56% for and Boscalid, respectively) [12][13][14], and despite extensive metabolism and biliary tion (elimination of radioactivity from radiolabeled Bixafen is characterized by a in plasma of 8-9 hours and a mean residence time of 13-19 hours [12]), it is still rea to assume a theoretical short-term exposure of cells to µM concentration of SDH posed at levels close to the AOELs. The remaining issue to be resolved is to add Other recent reports revealed neurodevelopmental defects in zebrafish models after exposure of embryos to Bixafen or Boscalid a few hours post-fertilization [5,6] as well as severe cardiac toxicity [7]. Chronic exposures (28 days) of adult zebrafish led to alterations in carbohydrate and lipid metabolism, and induced damage in the kidneys and the liver [8].…”

Section: Introductionmentioning

confidence: 99%

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The Short-Term Exposure to SDHI Fungicides Boscalid and Bixafen Induces a Mitochondrial Dysfunction in Selective Human Cell Lines

et al. 2021

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Fungicides are used to suppress the growth of fungi for crop protection. The most widely used fungicides are succinate dehydrogenase inhibitors (SDHIs) that act by blocking succinate dehydrogenase, the complex II of the mitochondrial electron transport chain. As recent reports suggested that SDHI-fungicides could not be selective for their fungi targets, we tested the mitochondrial function of human cells (Peripheral Blood Mononuclear Cells or PBMCs, HepG2 liver cells, and BJ-fibroblasts) after exposure for a short time to Boscalid and Bixafen, the two most used SDHIs. Electron Paramagnetic Resonance (EPR) spectroscopy was used to assess the oxygen consumption rate (OCR) and the level of mitochondrial superoxide radical. The OCR was significantly decreased in the three cell lines after exposure to both SDHIs. The level of mitochondrial superoxide increased in HepG2 after Boscalid and Bixafen exposure. In BJ-fibroblasts, mitochondrial superoxide was increased after Bixafen exposure, but not after Boscalid. No significant increase in mitochondrial superoxide was observed in PBMCs. Flow cytometry revealed an increase in the number of early apoptotic cells in HepG2 exposed to both SDHIs, but not in PBMCs and BJ-fibroblasts, results consistent with the high level of mitochondrial superoxide found in HepG2 cells after exposure. In conclusion, short-term exposure to Boscalid and Bixafen induces a mitochondrial dysfunction in human cells.

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Section: Introductionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Short-Term Exposure to SDHI Fungicides Boscalid and Bixafen Induces a Mitochondrial Dysfunction in Selective Human Cell Lines

et al. 2021

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“…W is extensively applied in several fields, including metallurgy, the chemical industry, optoelectronic devices, and the machinery industry . In particular, W has vital applications in quantum electronics, medical treatments, and military product manufacturing. − With the development of machinery, automobile, national defense, and electronics industries in China and the continuous progress of hard-alloy and W processing technology, the consumption of raw W in China has grown rapidly. Between 1990 and 2019, consumption increased from 10,000 tons to 48,000 tons, representing an average annual growth rate of 5.5%.…”

Section: Introductionmentioning

confidence: 99%

Theoretical Study of Efficient Photon–Phonon Resonance Absorption in the Tungsten-Related Vibrational Mode of Scheelite

Yin,

Li,

Liu

et al. 2024

ACS Omega

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Tungsten (W) is an extremely rare and vital metal extensively used in metallurgy, the chemical industry, optoelectronic devices, and machinery manufacturing. In this work, an environmentally friendly and efficient physical method based on photon−phonon resonance absorption (PPRA) is proposed for separating W from scheelite. We calculated the vibrational spectrum of calcium tungstate (CaWO 4 ) and assigned the infrared (IR) absorption and Raman scattering peaks through a dynamic analysis of the normal modes. We focused on the strong IR absorption peaks related to W and identified three high-intensity IR-active modes at around 830 cm −1 , corresponding to the stretching of the W− O bonds. Therefore, we propose the use of high-power terahertz (∼25 THz) laser radiation to facilitate W extraction from compounds, leveraging the high efficiency of PPRA. Experimental testing is required to determine the precise absorption frequency under industrial production conditions.

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“…Bixafen, a pyrazole carboxamide fungicide, was introduced by Bayer CropScience and first launched in the market in 2011 in the United Kingdom [3,8]. It is a broadspectrum systemic fungicide that is currently extensively used in agriculture to control fungal diseases in crops and boost production yields [3,4,6,9,10]. It is highly effective against Septoria tritici, Puccinia triticina, Puccinia striiformis, Oculimacula spp., and Pyrenophora tritici-repentis in wheat [8].…”

Section: Introductionmentioning

confidence: 99%

Electroanalytical Study of Fungicide Bixafen on Paste Electrode Based on the Thermally Reduced Graphene Oxide Synthesized in Air Conditions and its Determination in River Water Samples

et al. 2022

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An electrochemical study of the fungicide bixafen using a paste electrode based on thermally reduced graphene oxide (TRGOPE) synthesized in air is presented for the first time. Cyclic voltammetry and square-wave voltammetry (SWV) were conducted to characterize the mechanism of the underlying electrode process of bixafen. Optimization of the procedure for the quantitative determination of bixafen was carried out by SWV. Excellent electroanalytical performance in terms of a limit of detection of 31.5 nmol L À 1 was achieved. The TRGOPE was effectively employed to analyze bixafen in spiked river and tap water samples. The selectivity towards bixafen determination was also assessed.

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Bixafen causes cardiac toxicity in zebrafish (Danio rerio) embryos

Cited by 18 publications

References 63 publications

The Short-Term Exposure to SDHI Fungicides Boscalid and Bixafen Induces a Mitochondrial Dysfunction in Selective Human Cell Lines

The Short-Term Exposure to SDHI Fungicides Boscalid and Bixafen Induces a Mitochondrial Dysfunction in Selective Human Cell Lines

Theoretical Study of Efficient Photon–Phonon Resonance Absorption in the Tungsten-Related Vibrational Mode of Scheelite

Electroanalytical Study of Fungicide Bixafen on Paste Electrode Based on the Thermally Reduced Graphene Oxide Synthesized in Air Conditions and its Determination in River Water Samples

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