BK virus colonic ulcerations

“…Besides these direct effects, an oncogenic potential has been reported in patients with colorectal cancer [8]. Regarding gastrointestinal manifestations, a case of colonic ulceration associated with BKV has been published [9]. Its role in other immunocompromised populations has not been elucidated.…”

Section: Introductionmentioning

confidence: 99%

Prospective Study of BK Virus Infection in Patients with Inflammatory Bowel Disease

Flores

Rodríguez‐Sánchez

Marín-Jiménez

et al. 2014

The Scientific World Journal

View full text Add to dashboard Cite

Patients with inflammatory bowel disease (IBD) have an immune-deficient baseline status further modulated by immunosuppressive therapy that may promote the reactivation of latent viruses such as BK virus (BKV). The aim of this prospective study was to determine the prevalence of BKV infection in IBD patients and its potential relationship with the immunosuppressive treatment. Paired urine and plasma samples from 53 consecutive patients with IBD and 53 controls were analyzed. BKV detection was performed by conventional PCR and positive samples were further quantified by real-time PCR. No viremia was detected. BKV viruria was significantly more common in IBD patients than among the controls (54.7% versus 11.3%; P < 0.0001). The only risk factor for BKV viruria in IBD was age (47.2 ± 16.3 versus 37.8 ± 15.2; P = 0.036), and there was a trend towards higher rate of viruria in outpatients (61.5% versus 38.5%; P = 0.096) and in those not receiving ciprofloxacin (59.5% versus 40.5%; P = 0.17). A clear impact of the immunosuppressive regimen on BKV infection could not be demonstrated.

show abstract

“…With regard to humans, polyomavirus SV40 has been detected in the stool of hospitalized children and accidental recipients of virus contaminated polio vaccines [ 30 , 31 ]. There is also a case report of a kidney transplant patient who presented with diarrhea, colonic ulcers, inclusion bodies, and a positive PCR test for serum BKV DNA [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Gastrointestinal Tract as Potential Route of Primary Polyomavirus Infection in Mice

et al. 2016

View full text Add to dashboard Cite

BackgroundDetection of Polyomavirus (PyV) DNA in metropolitan rivers worldwide has led to the suggestion that primary viral infection can occur by the oral route. The aim of this study was to test this notion experimentally.MethodsMouse PyV (MPyV) was used to infect C57BL/6J mice by the nasal or intragastric route. Viral load kinetics was studied 3, 7, 10, 14, 21 and 28 days post-infection (dpi) using quantitative PCR.ResultsFollowing nasal infection, MPyV DNA was readily detected in many organs including lung, heart, aorta, colon, and stool with viral loads in the range of 103–106 copies/mg wet weight that peaked 7–10 dpi. Complete viral clearance occurred in the serum and kidney by 28 dpi, while clearance in other organs was partial with a 10–100 fold decrease in viral load. In contrast, following intragastric infection peak detection of PyV was delayed to 21 dpi, and viral loads were up to 3 logs lower. There was no detectable virus in the heart, colon, or stool.ConclusionsThe intragastric route of MPyV infection is successful, not as efficacious as the respiratory route, and associated with delayed viral dissemination as well as a lower peak MPyV load in individual organs.

show abstract

BK virus colonic ulcerations

Cited by 9 publications

References 18 publications

Polyomavirus disease in renal transplantationReview of pathological findings and diagnostic methods

Polyomavirus disease in renal transplantationReview of pathological findings and diagnostic methods

Prospective Study of BK Virus Infection in Patients with Inflammatory Bowel Disease

Evaluation of the Gastrointestinal Tract as Potential Route of Primary Polyomavirus Infection in Mice

Contact Info

Product

Resources

About