2014
DOI: 10.1016/j.bbmt.2014.01.014
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BK Virus Disease after Allogeneic Stem Cell Transplantation: A Cohort Analysis

Abstract: The clinical epidemiology of BK virus (BKV) disease after allogeneic hematopoietic stem cell transplantation (HSCT) is not well defined. We evaluated 491 patients transplanted from January 2010 to December 2011 at a single transplant center to assess incidence, severity, and risk factors for BKV disease after HSCT. BKV disease was defined as BKV detection in urine by PCR testing in association with genitourinary symptoms without other concurrent genitourinary conditions. BKV disease occurred in 78 patients (15… Show more

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Cited by 61 publications
(65 citation statements)
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“…However, the difference in study cohorts should be noted as the current study did not include cord blood HSCT and the most of patients received PBSCT. HLA-mismatched donor shown in the analysis among the group with mycophenolate and calcineurin inhibitor might support the alternate donor as a risk factor for HC as Rorije et al 4 and Gilis et al 28 have suggested (Supplementary Table 2). …”
Section: Discussionmentioning
confidence: 66%
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“…However, the difference in study cohorts should be noted as the current study did not include cord blood HSCT and the most of patients received PBSCT. HLA-mismatched donor shown in the analysis among the group with mycophenolate and calcineurin inhibitor might support the alternate donor as a risk factor for HC as Rorije et al 4 and Gilis et al 28 have suggested (Supplementary Table 2). …”
Section: Discussionmentioning
confidence: 66%
“…36 Many studies have tried to identify the risk factors for BK-HC in allo-HSCT. 1,3,4,10,23,24,28,31,32,37 Older age was identified as a risk factor in pediatric HSCTs, 2,3,31 but no other risk factor has been consistently verified in adult HSCTs, although aGVHD, BU-based conditioning regimens, the type of HSCT and the intensity of conditioning have been suggested. 4,10,23,24,26,30,32 Most recently, Rorije et al 4 reported a single-center, retrospective study.…”
Section: Discussionmentioning
confidence: 99%
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“…PyVHC afflicts 5 to 15% of HSCT patients after engraftment (2)(3)(4)(5). The pathogenesis of PyVHC is incompletely characterized but is believed to involve initial iatrogenic damage to the bladder mucosa during pretransplantation conditioning, which is subsequently aggravated by lytic BKPyV replication in urothelial cells in the absence of immune surveillance.…”
mentioning
confidence: 99%