Untitled

Brinton, Roberta Dı́az; Tran, Julie; Proffitt, Pam; Montoya, María Luisa Pedro-Botet

doi:10.1023/a:1022015005508

Cited by 169 publications

(14 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Estrogen receptors are found in brain regions responsible for verbal memory, working memory and retrieval, including the hippocampal formation and frontal lobes 8 . Estrogen promotes neuronal growth and survival 9 , and acts on the cholinergic system, which is closely linked to cognitive functioning, particularly memory 10 . Several studies suggest that cognitive function supported by the prefrontal cortex may be particularly sensitive to estrogen.…”

Section: Introductionmentioning

confidence: 99%

Reconciling subjective memory complaints with objective memory performance in the menopausal transition

et al. 2012

View full text Add to dashboard Cite

Objective The overall aim of this study was to examine the relationship between subjective memory complaints and objective cognitive performance in perimenopausal women. The specific aims were to determine: 1) if subjective complaints of memory problems relate to objective performance on memory tests, 2) if subjective complaints of memory problems relate to other domains of cognitive function and 3) if subjective memory complaints relate to other non-cognitive factors, such as depression, anxiety, and sleep quality. Methods Seventy-five perimenopausal women completed a comprehensive neuropsychological battery, which included measures of attention, working memory, verbal memory, verbal fluency, visuospatial skill, and fine motor dexterity, completed self-report inventories of their perceived memory and menopausal symptoms and provided serum levels of estradiol and follicle stimulating hormone. Results Memory complaints were not associated with verbal learning or verbal memory, but were associated with working memory and complex attention/vigilance. Memory complaints were also associated with symptoms of depression, anxiety, somatic complaints and sleep disturbance. Regression analyses revealed that memory complaints were best predicted by depressive symptoms, somatic complaints and working memory performance. Conclusions Memory complaints in the menopausal transition may reflect true difficulties with attentionally-mediated cognitive processes. Memory complaints may also be associated with other menopausal-related symptoms.

show abstract

Section: Introductionmentioning

confidence: 99%

Reconciling subjective memory complaints with objective memory performance in the menopausal transition

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Through its neurotrophic and differentiation-promoting effects, 17␤-estradiol acting via estrogen receptors (ERs) ␣ and ␤ is crucial for the sexual differentiation of CNS structures and functions during a ''critical period'' of brain development that extends from the late prenatal period until the first 2 weeks after birth (1). 17␤-Estradiol also stimulates neural differentiation and modulates neural survival both in vivo and in vitro (1,4,5) and promotes synapse formation and extension and branching of neurites of cortical neurons (6,7).…”

mentioning

confidence: 99%

Estrogen receptor (ER)β knockout mice reveal a role for ERβ in migration of cortical neurons in the developing brain

Wang¹,

Andersson²,

Warner³

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

208

140

View full text Add to dashboard Cite

The present study stems from our previous observations that the brains of adult estrogen receptor ␤ knockout (ER␤؊͞؊) mice show regional neuronal hypocellularity especially in the cerebral cortex. We now show that ER␤ is necessary for late embryonic development of the brain and is involved in both neuronal migration and apoptosis. At embryonic day (E)18.5, ER␤؊͞؊ mouse brains were smaller than those of the wild-type (WT) littermates, and there were fewer neurons in the cortex. There were no differences in size or cellularity at E14.5. When proliferating cells were labeled with 5-bromodeoxyuridine (BrdUrd) on E12.5, a time when cortical neurogenesis in mice begins, and examined on E14.5, there was no difference between WT and ER␤؊͞؊ mice in the number of labeled cells in the cortex. However, when BrdUrd was administered between E14.5 and E16.5, a time when postmitotic neurons migrate to layers of the cortex, there were fewer BrdUrd-labeled cells in the superficial cortical layers by E18.5 and postnatal day 14 in mice lacking ER␤. At E18.5, there were more apoptotic cells in the ventricular zone of mice lacking ER␤. In addition, the processes of the cortical radial glia, which are essential for guiding the migrating neurons, were fragmented. These findings suggest that by influencing migration and neuronal survival, ER␤ has an important role in brain development. In the CNS of developing and adult mammals, estrogens have actions that extend far beyond the control of reproduction (1-3). Through its neurotrophic and differentiation-promoting effects, 17␤-estradiol acting via estrogen receptors (ERs) ␣ and ␤ is crucial for the sexual differentiation of CNS structures and functions during a ''critical period'' of brain development that extends from the late prenatal period until the first 2 weeks after birth (1). 17␤-Estradiol also stimulates neural differentiation and modulates neural survival both in vivo and in vitro (1,4,5) and promotes synapse formation and extension and branching of neurites of cortical neurons (6, 7).The estrogen-synthesizing enzyme aromatase (8-10) as well as both nuclear ER␣ and ER␤ are expressed in many areas of the developing brain of several species (11)(12)(13)(14). In the developing mammalian brain, neurons destined to form the ordered layers of the cortex are generated in the ventricular and subventricular zones, lining the lateral ventricles, and must migrate along processes of the radial glia to their final destination. Cortical development begins with the formation of the preplate followed by the appearance of the cortical plate (CP), which is the precursor of most of the cortex (15). The period of neurogenesis in cortex in mice is between embryonic day (E)11 and E17 (16,17), and during this period the majority of CP neurons are generated. The CP increases in thickness by the addition of neurons migrating radially from the ventricular zones. Radial migrations then establish the neuronal layers with neurons migrating beyond previously established layers to settle at progressively more...

show abstract

“…During development, E2 permanently influences in vitro neurite production and dendritic branching in (a) hippocampalrat neurons [82], (b) selected populations of neocortical neurons [83], and (c) explants of the mouse preoptic area, thus suggesting that sexual differentiation of the brain involves hormone-stimulated dendrogenesis [84]. Similar effects on the dendritic elaboration induced through estradiol stimulation have also been reported for the cerebellum, where E2 appears capable of inducing increases in dendritic spine density [37] and de novo spine synthesis in the human cerebellum during critical developmental periods [30].…”

Section: Discussionmentioning

confidence: 99%

Sexually Diergic Trophic Effects of Estradiol Exposure on Developing Bovine Cerebellar Granule Cells

et al. 2016

View full text Add to dashboard Cite

In the mammalian brain, the differentiation of neural cells and the developmental organization of the underlying circuitry are influenced by steroid hormones. The estrogen 17-β estradiol (E2) is one of the most potent regulators of neural growth during prenatal life, synthetized locally from steroid precursors including prenatal testicular testosterone. Estradiol promotes brain differentiation counting sexually dimorphic neural circuits by binding to the estrogen receptors, ER-α and ER-β. The cerebellum has been described as a site of estrogen action and a potentially sexually dimorphic area. The goal of this study was to analyze the capacity of E2 to affect the growth of male and female fetal bovine cerebellar granule. We performed primary cultures of fetal cerebellar granules, and verified the mRNA expression of the ER-α and ER-β in both sexes. Moreover, the distribution of ERs in the male and female cerebellar granules of the second fetal stage was characterized by immunohistochemistry. We measured morphological parameters in presence (or absence) of estradiol administration, focusing on the variations of the dendritic branching pattern of granule neurons. By using the nonparametric combination and permutation testing approach, we proposed a sophisticated multivariate statistical analysis to demonstrate that E2 induces multifarious and dimorphic changes in the granule cells. E2 exerts trophic effects in both female and male granules and this effect is stronger in female. Male granules treated with E2 became similar to female control granule. Bos taurus species has a long gestation and a large brain that offers an interesting alternative in comparative neuroscience.

show abstract

Untitled

Cited by 169 publications

References 39 publications

Reconciling subjective memory complaints with objective memory performance in the menopausal transition

Reconciling subjective memory complaints with objective memory performance in the menopausal transition

Estrogen receptor (ER)β knockout mice reveal a role for ERβ in migration of cortical neurons in the developing brain

Sexually Diergic Trophic Effects of Estradiol Exposure on Developing Bovine Cerebellar Granule Cells

Contact Info

Product

Resources

About