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Lee, Stephen C.; Parthasarathy, R.; Duffin, Tiffany; Botwin, K.; Zobel, James; Beck, T.; Lange, Gary; Kunneman, D.; Janssen, Robert S.; Rowold, Edwin; Voliva, Charles F.

doi:10.1023/a:1011429404950

Cited by 22 publications

(6 citation statements)

References 8 publications

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“…Most importantly, unconjugated fullerenes, even in the presence of Freud adjuvants, were not immunogenic ( 133 ). Similar results were obtained with PAMAM dendrimers ( 138 , 139 ). Dendrimer conjugation to a protein (hIL-3 or BSA) resulted in the formation of a dendrimer-specific antibody response ( 139 ).…”

Section: Immunogenicitysupporting

confidence: 86%

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Lessons learned from immunological characterization of nanomaterials at the Nanotechnology Characterization Laboratory

Dobrovolskaia

2022

Front. Immunol.

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Nanotechnology carriers have become common in pharmaceutical products because of their benefits to drug delivery, including reduced toxicities and improved efficacy of active pharmaceutical ingredients due to targeted delivery, prolonged circulation time, and controlled payload release. While available examples of reduced drug toxicity through formulation using a nanocarrier are encouraging, current data also demonstrate that nanoparticles may change a drug’s biodistribution and alter its toxicity profile. Moreover, individual components of nanoparticles and excipients commonly used in formulations are often not immunologically inert and contribute to the overall immune responses to nanotechnology-formulated products. Said immune responses may be beneficial or adverse depending on the indication, dose, dose regimen, and route of administration. Therefore, comprehensive toxicology studies are of paramount importance even when previously known drugs, components, and excipients are used in nanoformulations. Recent data also suggest that, despite decades of research directed at hiding nanocarriers from the immune recognition, the immune system’s inherent property of clearing particulate materials can be leveraged to improve the therapeutic efficacy of drugs formulated using nanoparticles. Herein, I review current knowledge about nanoparticles’ interaction with the immune system and how these interactions contribute to nanotechnology-formulated drug products’ safety and efficacy through the lens of over a decade of nanoparticle characterization at the Nanotechnology Characterization Laboratory.

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Section: Immunogenicitysupporting

confidence: 86%

“…Similar results were obtained with PAMAM dendrimers ( 138 , 139 ). Dendrimer conjugation to a protein (hIL-3 or BSA) resulted in the formation of a dendrimer-specific antibody response ( 139 ). The induced antibodies reacted with dendrimer surface groups ( 139 ).…”

Section: Immunogenicitysupporting

confidence: 86%

Lessons learned from immunological characterization of nanomaterials at the Nanotechnology Characterization Laboratory

Dobrovolskaia

2022

Front. Immunol.

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“…Dendrimers are a new class of nanomaterials which have well‐defined cavities 2 and terminal groups 3. They can provide higher surface area and development of biocompatible surfaces.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Detection of Activated Protein C Using an Aptasensor Based on PAMAM Dendrimer Modified Pencil Graphite Electrodes

2014

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Obwohl sich der Bereich der organischen Elektronik im Laufe der letzten Jahre erheblich weiterentwickelt hat, wird er noch immer durch die Zahl verfügbarer Materialien beschränkt. Ein weiterer Ausbau erfordert die Einführung neuartiger π‐konjugierter Rückgrate, geeignete Kandidaten hierfür werden aber nur sehr selten entdeckt. Die Einführung einer neuen Klasse konjugierter Materialien – der langen α‐Oligofurane – wurde daher vor kurzem mit großem Interesse begrüßt. α‐Oligofurane weisen viele Eigenschaften auf, die für Anwendungen in organischen elektronischen Materialien erforderlich sind, und sollen biologisch abbaubar sein. Dieser Kurzaufsatz bietet eine Beschreibung langer Oligofurane aus der Perspektive ihrer Synthese, molekularen Eigenschaften, chemischen Reaktivität und Verwendung in elektronischen Bauelementen.

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“…Dendrimers resemble covalent micelles characterized by well-defined cavities [17] responsible for their particular endoreceptor properties [18] and terminal groups that define the solubility [19], the reactivity [20], and the exoreceptor characteristics of the molecule [21]. Due to their intrinsic and exciting properties, dendrimers have been studied as an important new class of potential drug delivery system [22], protein models [23], molecular antennas [24], and catalytic materials [25].…”

Section: Introductionmentioning

confidence: 99%

PAMAM Dendrimers‐Based DNA Biosensors for Electrochemical Detection of DNA Hybridization

Zhu

et al. 2006

Electroanalysis

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Gold electrodes were modified with submonolayers of mercaptoacetic acid (RSH) and further reacted with poly(amidoamine) (PAMAM) dendrimers (generation 4.0) to obtain thin films, on which DNA probe was later immobilized to afford a stable recognition layers. The characterization of the PAMAM/RSH-modified electrode was investigated by cyclic voltammetry (CV) and electrochemical impedance measurement. Differential pulse voltammogram (DPV) measurement was used to monitor DNA hybridization with daunomycin (DNR) as indicator. Experiments carried out with these novel materials not only showed an improved DNA attachment quantity on the dendrimers-modified electrodes compared to DNA sensors with oligonucleotides directly immobilized on Au electrodes, but also exhibited a high selectivity, sensitivity and stability for the measurement of DNA hybridization.

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Untitled

Cited by 22 publications

References 8 publications

Lessons learned from immunological characterization of nanomaterials at the Nanotechnology Characterization Laboratory

Lessons learned from immunological characterization of nanomaterials at the Nanotechnology Characterization Laboratory

Electrochemical Detection of Activated Protein C Using an Aptasensor Based on PAMAM Dendrimer Modified Pencil Graphite Electrodes

PAMAM Dendrimers‐Based DNA Biosensors for Electrochemical Detection of DNA Hybridization

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