Black carp TRADD suppresses MAVS/IFN signaling during the innate immune activation

Li, Wanzhen; Cao, Yingyi; Chen, Zhaoyuan; Tan, Yaqi; Dai, Yuhan; Wei, Jing; Xiao, Jun; Feng, Hao

doi:10.1016/j.fsi.2021.01.006

Cited by 10 publications

(4 citation statements)

References 43 publications

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“…GCRV infection induced the expression of piscine receptor‐interacting serine/threonine protein kinase 1 (RIPK1), NLR family member X1 (NLRX1), tumour necrosis factor receptor 1 associated death domain protein (TRADD) and nemo‐like kinase 2 (NLK2). The RIPK1, NLRX1 and TRADD from black carp suppressed MAVS‐mediated antiviral signalling for promoting the replication of GCRV‐106 145–147 . In grass carp, NLK2 could directly interact with MAVS and promoted the phosphorylation level of MAVS, which led to the degradation of MAVS protein 148 .…”

Section: Immune Escape Mechanisms By Aqrvsmentioning

confidence: 99%

“…The RIPK1, NLRX1 and TRADD from black carp suppressed MAVS-mediated antiviral signalling for promoting the replication of GCRV-106. [145][146][147] In grass carp, NLK2 could directly interact with MAVS and promoted the phosphorylation level of MAVS, which led to the degradation of MAVS protein. 148 Since cells and viruses regulate MAVS at both post-transcriptional and post-translational levels using multiple mechanisms, 149 further studies to elucidate the mechanistic details are still required for various strategies employed by AqRVs to antagonise MAVS activity.…”

Section: The Replication and Infection Of Aqrvsmentioning

confidence: 99%

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Structure, function and immune evasion strategies of aquareoviruses, with focus on grass carp reovirus

Zhang

Chang

2023

Reviews in Aquaculture

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Aquareoviruses (AqRVs) can infect various wild or cultured bony fishes with serious muscle and viscera haemorrhage syndrome and have caused severe economic losses worldwide. Accumulating evidences have revealed the functions of viral proteins of AqRVs in RNA transcription, virion assembly, cell attachment and/or viral replication. In addition, structural information and transcription mechanism of AqRVs have been in‐depth studied through cryo‐electron microscopy combined with three‐dimensional image reconstruction. Although far from enough, structural and functional studies of AqRVs provide substantial insights into how viral proteins coordinate the replication of AqRVs and escape the host immune response. Grass carp reovirus (GCRV) is the most pathogenic AqRV isolated from aquatic animals. The completion of GCRV lifecycle requires the participation of host proteins. So far, many host factors involved in the entry and replication of GCRV have been identified. Based on the function of viral proteins and the viral lifecycle, many vaccines and antiviral agents have been developed to prevent the replication and infection of GCRV. This review summarises the structural characteristics and the composition of core proteins of AqRVs, as well as synergistic mechanisms of structural proteins on genome transcription and virus entry of AqRVs. In addition, the review highlights our current knowledge for the infection and replication, functions of non‐structural proteins, immune escape mechanisms, as well as the vaccines and antiviral agents of AqRVs, especially for GCRV. A better understanding of structure, function and immune evasion strategies of AqRVs will offer new targets for prevention and control of AqRVs in aquaculture.

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Section: Immune Escape Mechanisms By Aqrvsmentioning

confidence: 99%

Section: The Replication and Infection Of Aqrvsmentioning

confidence: 99%

Structure, function and immune evasion strategies of aquareoviruses, with focus on grass carp reovirus

Zhang

Chang

2023

Reviews in Aquaculture

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“…Therefore, the integrity of these subcellular compartments together with their own regulation indirectly act on RLR function ( 111 , 112 ). A few examples of such mechanisms have been described in fish cells, mainly miRNA-mediated regulation and alternative splicing isoforms of RLR components ( 113 , 114 ).…”

Section: Regulation Of Rig-i-like Receptorsmentioning

confidence: 99%

“…A few examples of such mechanisms have been described in fish cells, mainly miRNA-mediated regulation and alternative splicing isoforms of RLR components (113,114). In order to explore the degree of conservation of these regulatory mechanisms among vertebrates, we cloned and fully sequenced 22 genes of fathead minnow (Pimephales promelas) encoding orthologs of human proteins described as important regulators of the RIG-I pathway (Table 1).…”

Section: Regulation Of Rig-i-like Receptorsmentioning

confidence: 99%

Deciphering the Fine-Tuning of the Retinoic Acid-Inducible Gene-I Pathway in Teleost Fish and Beyond

et al. 2021

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Interferons are the first lines of defense against viral pathogen invasion during the early stages of infection. Their synthesis is tightly regulated to prevent excessive immune responses and possible deleterious effects on the host organism itself. The RIG-I-like receptor signaling cascade is one of the major pathways leading to the production of interferons. This pathway amplifies danger signals and mounts an appropriate innate response but also needs to be finely regulated to allow a rapid return to immune homeostasis. Recent advances have characterized different cellular factors involved in the control of the RIG-I pathway. This has been most extensively studied in mammalian species; however, some inconsistencies remain to be resolved. The IFN system is remarkably well conserved in vertebrates and teleost fish possess all functional orthologs of mammalian RIG-I-like receptors as well as most downstream signaling molecules. Orthologs of almost all mammalian regulatory components described to date exist in teleost fish, such as the widely used zebrafish, making fish attractive and powerful models to study in detail the regulation and evolution of the RIG-I pathway.

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Infection by a helminth parasite is associated with changes in DNA methylation in the house sparrow

Lundregan

Mäkinen

Buer

et al. 2022

Ecology and Evolution

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Parasites can exert strong selective pressures on their hosts and influence the evolution of host immunity. While several studies have examined the genetic basis for parasite resistance, the role of epigenetics in the immune response to parasites is less understood. Yet, epigenetic modifications, such as changes in DNA methylation, may allow species to respond rapidly to parasite prevalence or virulence. To test the role of DNA methylation in relation to parasite infection, we examined genome‐wide DNA methylation before and during infection by a parasitic nematode, Syngamus trachea , in a natural population of house sparrows ( Passer domesticus ) using reduced representation bisulfite sequencing (RRBS). We found that DNA methylation levels were slightly lower in infected house sparrows, and we identified candidate genes relating to the initial immune response, activation of innate and adaptive immunity, and mucus membrane functional integrity that were differentially methylated between infected and control birds. Subsequently, we used methylation‐sensitive high‐resolution melting (MS‐HRM) analyses to verify the relationship between methylation proportion and S. trachea infection status at two candidate genes in a larger sample dataset. We found that methylation level at NR1D1 , but not CLDN22 , remained related to infection status and that juvenile recruitment probability was positively related to methylation level at NR1D1 . This underscores the importance of performing follow‐up studies on candidate genes. Our findings demonstrate that plasticity in the immune response to parasites can be epigenetically mediated and highlight the potential for epigenetic studies in natural populations to provide further mechanistic insight into host–parasite interactions.

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Black carp TRADD suppresses MAVS/IFN signaling during the innate immune activation

Cited by 10 publications

References 43 publications

Structure, function and immune evasion strategies of aquareoviruses, with focus on grass carp reovirus

Structure, function and immune evasion strategies of aquareoviruses, with focus on grass carp reovirus

Deciphering the Fine-Tuning of the Retinoic Acid-Inducible Gene-I Pathway in Teleost Fish and Beyond

Infection by a helminth parasite is associated with changes in DNA methylation in the house sparrow

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