The COVID-19 pandemic was a worldwide disaster in the health industry, millions of human deaths were recorded. The spread of the virus led to the shutting down of the world economy. The most prevalent is people communicating in close contact. Measures such as the use of nose masks and social distancing help to reduce the infection rate. The second is infection from substrates like tables, automated teller machine buttons, staircase rails, door nubs, etc. This paper is poised to review how surface-infected (substrates) platforms can be inactivated using modified functional coating systems. These coating composite systems are prepared by functionalizing the polymer matrix with suitable nanoparticles that could inactivate the SARS-CoV-2 virus. Furthermore, this piece discusses the challenges and future directions in the development of advanced coating technologies, aiming to enhance their effectiveness and applicability in diverse settings, including healthcare facilities and public spaces. This review serves as a valuable resource for scientists, engineers, and policymakers involved in the ongoing efforts to combat the COVID-19 pandemic.