The present work is devoted to investigate anisotropic conformal transformation of conic pseudo-Finsler surfaces $(M,F)$, that is, $ F(x,y)\longmapsto \overline{F}(x,y)=e^{\phi(x,y)}F(x,y)$, where the function $\phi(x,y)$ depends on both position $x$ and direction $y$, contrary to the ordinary (isotropic) conformal transformation which depends on position only. If $F$ is a pseudo-Finsler metric, the above transformation does not yield necessarily a pseudo-Finsler metric. Consequently, we find out necessary and sufficient condition for a (conic) pseudo-Finsler surface $(M,F)$ to be transformed to a (conic) pseudo-Finsler surface $(M,\overline{F})$ under the transformation $\overline{F}=e^{\phi(x,y)}F$. In general dimension, it is extremely difficult to find the anisotropic conformal change of the inverse metric tensor in a tensorial form. However, by using the modified Berwald frame on a Finsler surface, we obtain the change of the components of the inverse metric tensor in a tensorial form. This progress enables us to study the transformation of the Finslerian geometric objects and the geometric properties associated with the transformed Finsler function $\overline{F}$. In contrast to isotropic conformal transformation, we have a non-homothetic conformal factor $\phi(x,y)$ that preserves the geodesic spray. Also, we find out some invariant geometric objects under the anisotropic conformal change. Furthermore, we investigate a sufficient condition for $\overline{F}$ to be dually flat or/and projectively flat. Finally, we study some special cases of the conformal factor $\phi(x,y)$. Various examples are provided whenever the situation needs.