Black Mulberry Extract Elicits Hepatoprotective Effects in Nonalcoholic Fatty Liver Disease Models by Inhibition of Histone Acetylation

Chung, Min‐Yu; Kim, Hyo-Jin; Choi, Hyo‐Kyoung; Park, Jae Ho

doi:10.1089/jmf.2021.k.0048

Cited by 4 publications

(5 citation statements)

References 34 publications

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“…In addition, mulberry 1‐DNJ improved cardiac functions via suppressing oxidative stress, myocardial fibrosis, expression of collagen 1 and 3, Smad2/3, and alpha‐smooth muscle actin (Cao et al, 2021). Also, suppression of hepatic lipogenic genes expression, bad cholesterol, and non‐esterified fatty acids (Chung et al, 2021). Furthermore, a significant increase in blood and hepatic HDL levels (Lee, Lee, et al, 2020; Singh et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Phytochemical characterization ofMorus nigrafruit ultrasound‐assisted ethanolic extract for its cardioprotective potential

Maqsood

Khan

Sharif

et al. 2022

Journal of Food Biochemistry

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The current work investigated the phytochemical profile of ultrasound‐assisted ethanolic extract of Morus nigra (M. nigra) fruit. FTIR analysis of M. nigra fruit extract revealed the presence of alcohols (O‐H), alkanes (C‐H stretch), alkenes (C=C), and alkynes (C≡C). The HPLC analysis quantified the quercetin, gallic acid, vanillic acid, chlorogenic acid, syringic acid, cinnamic acid, sinapic acid, and kaempferol. Furthermore, the cardioprotective activity of ethanolic extract of M. nigra fruit was investigated. Cholesterol supplementation (2%) in the daily diet and exposure to cigarette smoke (2 cigarettes twice a day) were to induce hypertension in rats. The experimental animals were categorized into four groups: G0 (negative control), G1 (positive control), G2 (standard drug), and G3 (M. nigra fruit). The fruit extract administration at 300 mg/kg BW/day orally for 2 months significantly (p < .001) enhanced the activities of serum and cardiac tissue antioxidants in hypertensive rats. Meanwhile, the fruit extract reduced the elevated serum lipid profile while significantly increasing the high‐density lipoproteins in G3 than G1 and G2. The increase in blood pressure, liver transaminases, and serum lactate dehydrogenase also reduced significantly in M. nigra fruit extract‐treated rats. Histopathological findings revealed mild normalization of cardiac myocytes with central nuclei, branching, and cross‐striations. Consequently, the M. nigra fruit extract exerted the cardioprotective potential via increasing the antioxidant enzymes and reducing the lipids, lactate dehydrogenase, liver transaminases, and blood pressure. The therapeutic potential of M. nigra fruit can be due to flavonols and phenolic acids. Practical applications The present work quantified the Morus nigra fruit phytochemicals and its significant role in reducing lipid markers and blood pressure and improving antioxidant status in rats fed a hypercholesterolemic diet and exposed to cigarette smoke. Conclusively, the inclusion of M. nigra fruit in daily diet could improve the cardiac health of the individuals. Furthermore, the therapeutic potential of M. nigra fruit and its isolated constituents in modulating the gene expression against cardiac problems can explore after clinical trials and standardization in higher animals.

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Section: Discussionmentioning

confidence: 99%

Phytochemical characterization ofMorus nigrafruit ultrasound‐assisted ethanolic extract for its cardioprotective potential

Maqsood

Khan

Sharif

et al. 2022

Journal of Food Biochemistry

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“…They also investigated the in vivo hypolipidemic potential of extract supplementation (1%) in obese mice for 12 weeks. The extract suppressed the expression of liver lipogenic genes, lowering bad cholesterol and non‐esterified fatty acids (Chung et al, 2021). Various doses of M. nigra lyophilized extracts ranging from 150 to 300 mg/kg exerted significant potential against carbon tetrachloride‐induced liver injury.…”

Section: Therapeutic Effectsmentioning

confidence: 99%

“…The medicinal value of the fruit has been demonstrated due to the presence of significant antioxidants with anti‐inflammatory, anticancer, antidiabetic, hepatoprotective, antibacterial, and neuroprotective properties (Chung et al, 2021; Jung, Lee, et al, 2019; Kim et al, 2019; Long et al, 2018; Long et al, 2021; Shalan et al, 2020). The leaves exhibit anti‐mutagenic, hypotensive, nephroprotective, neuroprotective, hypoglycemic, hypolipidemic, hepatoprotective, and anti‐obesity properties (Basu et al, 2021; Cao et al, 2021; El‐Sheshtawy et al, 2021; Fan et al, 2020; Lee, Kim, Yun, et al, 2017; Pothinuch et al, 2017; Rayam et al, 2019; Wu, 2019; Yamamoto et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Mulberry plant as a source of functional food with therapeutic and nutritional applications: A review

Maqsood

Saeed

Sahar

et al. 2022

Journal of Food Biochemistry

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Medicinal plants from the family Moraceae have diverse applications in agriculture, cosmetics, food, and the pharmaceutical industry. Their extensive spectrum of pharmacological activity for treating numerous inflammatory illnesses, cancer, cardiovascular diseases, and gastrointestinal problems reflects their biological and therapeutic value. This article summarizes the molecular mechanisms related to the biological implications of mulberry extracts, fractions, and isolated bioactive compounds from different parts in various health‐related ailments. Additionally, the food industry and animal nutrition applications are summarized. Phytochemicals such as steroids, saponins, alkaloids, glycosides, polysaccharides, and phenolic compounds including terpenoids, flavonoids, anthocyanins, and tannins are found in this medicinal plant. The aqueous, ethanolic, and methanolic extracts, as well as bioactive compounds, have anti‐oxidative, hypoglycemic, nephroprotective, antimicrobial, neuroprotective, anti‐mutagenic, hepatoprotective, anthelmintic, immune‐modulatory, cardioprotective, and skin protecting activities. Mulberry supplementation in food products improves the stability of phenolics, sensory properties, antioxidant activity, and antimicrobial properties. Mulberry leaves in animal feed increase the nutrient digestibility, growth parameters, antimicrobial, and antioxidant properties. Practical applications This review summarized the in vivo and in vitro biological activities of the mulberry and isolated constituents in various health conditions. In addition, the food uses such as antioxidant potential, antimicrobial, and physicochemical properties were discussed. Furthermore, in vivo studies revealed mulberry as a significant protein source and its flavonoids as potential animal foliage.

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“…Histone modifications : In vitro assays have shown that tannic acid (a hydrolysable tannin polyphenol found in many dietary plant products such as coffee, tea, cocoa, and sorghum grain) ameliorates lipid accumulation via downregulation of lipogenesis-related gene ( SREBP-1c , ACLY , FASN , PPARγ ) expression and inhibition of histone acetyltransferase activity in HepG2 human cells [ 32 ]. Using this same cell line, black mulberry fruit extract markedly reduced the expression of proteins associated with lipogenesis, which was attributed to suppression of total acetylated lysine as well as specific histone acetylation of proteins H3K14 and H3K27 [ 33 ]. Likewise, Schisandra chinensis berry extract protected against steatosis development by inhibiting histone H3K9 acetylation in oleic acid-treated HepG2 cells [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

Multi-Omics Nutritional Approaches Targeting Metabolic-Associated Fatty Liver Disease

Ramos-López

2022

Genes

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Currently, metabolic-associated fatty liver disease (MAFLD) is a leading global cause of chronic liver disease, and is expected to become one of the most common indications of liver transplantation. MAFLD is associated with obesity, involving multiple mechanisms such as alterations in lipid metabolism, insulin resistance, hyperinflammation, mitochondrial dysfunction, cell apoptosis, oxidative stress, and extracellular matrix formation. However, the onset and progression of MAFLD is variable among individuals, being influenced by intrinsic (personal) and external environmental factors. In this context, sequence structural variants across the human genome, epigenetic phenomena (i.e., DNA methylation, histone modifications, and long non-coding RNAs) affecting gene expression, gut microbiota dysbiosis, and metabolomics/lipidomic fingerprints may account for differences in MAFLD outcomes through interactions with nutritional features. This knowledge may contribute to gaining a deeper understanding of the molecular and physiological processes underlying MAFLD pathogenesis and phenotype heterogeneity, as well as facilitating the identification of biomarkers of disease progression and therapeutic targets for the implementation of tailored nutritional strategies. This comprehensive literature review highlights the potential of nutrigenetic, nutriepigenetic, nutrimetagenomic, nutritranscriptomics, and nutrimetabolomic approaches for the prevention and management of MAFLD in humans through the lens of precision nutrition.

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Black Mulberry Extract Elicits Hepatoprotective Effects in Nonalcoholic Fatty Liver Disease Models by Inhibition of Histone Acetylation

Cited by 4 publications

References 34 publications

Phytochemical characterization ofMorus nigrafruit ultrasound‐assisted ethanolic extract for its cardioprotective potential

Phytochemical characterization ofMorus nigrafruit ultrasound‐assisted ethanolic extract for its cardioprotective potential

Mulberry plant as a source of functional food with therapeutic and nutritional applications: A review

Multi-Omics Nutritional Approaches Targeting Metabolic-Associated Fatty Liver Disease

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