Black phosphorous-based biomaterials for bone defect regeneration: a systematic review and meta-analysis

Huang, Jinfeng; Santos, Ana Cláudia; Tan, Quanchang; Bai, Hao; Hu, Xiaofan; Mamidi, Narsimha; Wu, Zixiang

doi:10.1186/s12951-022-01735-9

Cited by 4 publications

(1 citation statement)

References 75 publications

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“…Black phosphorus (BP) has demonstrated outstanding in vivo biodegradability compared to other 2D nanomaterials, making it a safer and highly promising candidate for biomedical applications (Huang et al, 2022). Despite this, the unique advantages of BP over other 2D materials in various biomedical applications have not been clearly summarized (Choi et al, 2018;Nyrop et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Recent development in black phosphorus nanomaterials for anticancer applications

Gao

Wang

Sun

et al. 2023

Front. Biomater. Sci.

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Black phosphorus (BP), also referred to as phosphorene, has gained significant attention in recent years due to its unique structure and properties since its successful exfoliation in 2014. BP’s remarkable optical and mechanical properties, electrical conductivity, and electron transfer capabilities position it as a promising alternative to graphene for various biomedical applications. This article provides an overview of the use of BP in cancer imaging, drug delivery, and combination therapy, as well as the challenges and prospects of utilizing BP in practical biomedical applications. While BP shows great potential for biomedical applications, practical implementation remains challenging. Therefore, this review article aims to summarize the latest research on BP and provide insights into its future applications in the biomedical field.

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Section: Introductionmentioning

confidence: 99%

Recent development in black phosphorus nanomaterials for anticancer applications

Gao

Wang

Sun

et al. 2023

Front. Biomater. Sci.

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Recent Advances in Biomacromolecule‐Reinforced 2D Material (2DM) Hydrogels: From Interactions, Synthesis, and Functionalization to Biomedical Applications

Gu,

Cui,

et al. 2024

Adv Funct Materials

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Regenerative biomedicine has emerged as a forefront area in medical research, heralding a new era of therapeutic strategies. This review delineates the integration of 2D materials (2DMs) within the area of biomedical engineering, leveraging their superior physicochemical attributes for enhance biomedical outcomes. The synergistic interaction between biomacromolecules and 2DMs is explored, demonstrating their potential to mitigate the limitations inherent to each while simultaneously augmenting their beneficial properties. In particular, incorporating 2DMs into hydrogels highlights their capability to enhance the mechanical strength of hydrogels, providing a biomimetic scaffold for tissue engineering regeneration and cancer diagnosis and therapy. An overview of the synthetic methodologies are provided for 2DMs, elucidating their interaction dynamics with biomacromolecules. The review primarily concentrates on the applications of biomacromolecule‐reinforced 2DM hydrogels across various biomedical fields, including bone tissue engineering, wound healing, neural tissue engineering, cardiac tissue engineering, as well as in the delivery of drugs and genes, cancer therapy, and biosensing technologies. Finally, the review discusses the existing challenges and future outlook for developing and using biomacromolecule‐reinforced 2DM hydrogels, underlining their transformative potential in regenerative medicine.

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3D Bioprinted Tissue‐Engineered Bone with Enhanced Mechanical Strength and Bioactivities: Accelerating Bone Defect Repair through Sequential Immunomodulatory Properties

Liu,

Zhao

et al. 2024

Adv Healthcare Materials

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In this study, a new‐generation tissue‐engineered bone capable of temporally regulating the immune response, balancing proinflammatory and anti‐inflammatory activities, and facilitating bone regeneration and repair to address the challenges of delayed healing and nonunion in large‐sized bone defects, is innovatively developed. Using the innovative techniques including multiphysics‐assisted combined decellularization, side‐chain biochemical modification, and sterile freeze‐drying, a novel photocurable extracellular matrix hydrogel, methacrylated bone‐derived decellularized extracellular matrix (bdECM‐MA), is synthesized. After incorporating the bdECM‐MA with silicon‐substituted calcium phosphate and bone marrow mesenchymal stem cells, the tissue‐engineered bone is fabricated through digital light processing 3D bioprinting. This study provides in vitro confirmation that the engineered bone maintains high cellular viability while achieving MPa‐level mechanical strength. Moreover, this engineered bone exhibits excellent osteogenesis, angiogenesis, and immunomodulatory functions. One of the molecular mechanisms of the immunomodulatory function involves the inhibition of the p38‐MAPK pathway. A pioneering in vivo discovery is that the natural biomaterial‐based tissue‐engineered bone demonstrates sequential immunomodulatory properties that activate proinflammatory and anti‐inflammatory responses in succession, significantly accelerating the repair of bone defects. This study provides a new research basis and an effective method for developing autogenous bone substitute materials and treating large‐sized bone defects.

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Black phosphorous-based biomaterials for bone defect regeneration: a systematic review and meta-analysis

Cited by 4 publications

References 75 publications

Recent development in black phosphorus nanomaterials for anticancer applications

Recent development in black phosphorus nanomaterials for anticancer applications

Recent Advances in Biomacromolecule‐Reinforced 2D Material (2DM) Hydrogels: From Interactions, Synthesis, and Functionalization to Biomedical Applications

3D Bioprinted Tissue‐Engineered Bone with Enhanced Mechanical Strength and Bioactivities: Accelerating Bone Defect Repair through Sequential Immunomodulatory Properties

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