Black phosphorous nanomaterials as a new paradigm for postoperative tumor treatment regimens

Abstract

Surgery is currently a mainstream treatment modality for various solid tumor indications. However, aggressive resection of tumor tissues frequently causes postoperative complications, which severely undermine the well-being of patients. Moreover, the residue tumor cells may substantially increase the risk of local and distant tumor relapse. The recent development in black phosphorus (BP)-based nanomaterials offers a promising opportunity to address these clinical challenges. BP is an emerging nanomaterial with excellent biocompatibility and versatile functionality, which has already demonstrated great potential for a variety of biomedical applications including tumor therapy and tissue engineering. In this review, the recent advances in BP-based nanobiomaterials for the post-surgery treatment of solid tumor have been summarized, while specific emphasis was placed on their capability to continuously inhibit residue tumor growth at the surgery site as well as stimulating various healing mechanisms, aiming to preventing tumor relapse while promoting the healing of surgery-induced traumatic soft/hard tissue injuries. It is anticipated that the nanoengineered BP-based materials may open new avenues to tackle those clinical challenges in surgical treatment of solid tumors.

Advances in H2O2-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

“…Then post-operative restoration needs to be considered. 180 Recent research proposed that epidermal regeneration and bone reconstruction may have different design requirements. 181–184 For H 2 O 2 -supplying materials, the antitumor capacity was a non-specific effect that may injure the healthy cells.…”

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

“…Bioactive ceramics hydroxyapatites coatings on metallic implants [177][178][179] fluorapatite-based composites bone applications [180] bioactive glasses bone substitute and drug carrier [181] bioactive glass ceramics chemo hyperthermia [182] Biodegradable (bioresorbable)ceramics aluminium-calcium phosphate biomedical application [183] zinc-calcium phosphorous oxides postoperative tumour treatment [184] zinc-sulfate-calcium phosphates tissue engineering [185] ferric-calcium phosphorous oxides scaffolding for cell and drug delivery [186] coralline drugs [187] calcium aluminates bioactive dental materials [188] Bioinert (nonresorbable) ceramics alumina drug delivery [189] zirconia biomedical applications [190] carbons biomedical applications for tissue engineering [191] silicon nitride biomedical applications in medical implants [192]…”

“…Bioactive ceramics hydroxyapatites coatings on metallic implants [177][178][179] fluorapatite-based composites bone applications [180] bioactive glasses bone substitute and drug carrier [181] bioactive glass ceramics chemo hyperthermia [182] Biodegradable (bioresorbable)ceramics aluminium-calcium phosphate biomedical application [183] zinc-calcium phosphorous oxides postoperative tumour treatment [184] zinc-sulfate-calcium phosphates tissue engineering [185] ferric-calcium phosphorous oxides scaffolding for cell and drug delivery [186] coralline drugs [187]…”

Black phosphorus, an advanced versatile nanoparticles of antitumor, antibacterial and bone regeneration for OS therapy

“…Therefore, BP nanoparticles offer greater potential for cancer therapy compared to other 2D nanomaterials. In addition, with its features of PTT, PDT, photoacoustic therapy (PAT), drug delivery system (DDS) and biological, BP nanoparticles would become a promising material for OS therapy ( Figure 1 ) ( Raucci et al, 2019a ; Zhang et al, 2019 ; Wang et al, 2020b ; Hu et al, 2022a ; Ma et al, 2022a ; Dong et al, 2022 ; Hou et al, 2022 ; Li et al, 2023b ; Li et al, 2023d ).…”