Black phosphorus (BP)–graphene guided-wave surface plasmon resonance (GWSPR) biosensor

Su, Ming‐Yang; Chen, Xueyu; Tang, Linwei; Yang, Bo; Zou, Haijian; Liu, Junmin; Liu, Ying; Chen, Shuqing; Fan, Dianyuan

doi:10.1515/nanoph-2020-0251

Cited by 21 publications

(6 citation statements)

References 40 publications

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“…Furthermore, we can see that the sensitivity first increases and then decreases with the increase in MoS 2 layers. This can be explained that as the number of MoS 2 layers continuously increases, the resonance angle will increase to 90 • , but the detection angle cannot reach 90 • , limiting the sensitivity of the SPR sensor [37]. When the number of MoS 2 layers is four (M = 4), the highest sensitivity of 282 • /RIU is obtained, which is significantly improved as compared to the other reported works [22,23,27].…”

Section: Numerical Simulation Design the Proposed Spr Biosensormentioning

confidence: 84%

Performance Enhancement of SPR Biosensor Using Graphene–MoS2 Hybrid Structure

Cai

Wang

et al. 2022

Nanomaterials

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We investigate a high-sensitivity surface plasmon resonance (SPR) biosensor consisting of a Au layer, four-layer MoS2, and monolayer graphene. The numerical simulations, by the transfer matrix method (TMM), demonstrate the sensor has a maximum sensitivity of 282°/RIU, which is approximately 2 times greater than the conventional Au-based SPR sensor. The finite difference time domain (FDTD) indicates that the presence of MoS2 film generates a strong surface electric field and enhances the sensitivity of the proposed SPR sensor. In addition, the influence of the number of MoS2 layers on the sensitivity of the proposed sensor is investigated by simulations and experiments. In the experiment, MoS2 and graphene films are transferred on the Au-based substrate by the PMMA-based wet transfer method, and the fabricated samples are characterized by Raman spectroscopy. Furthermore, the fabricated sensors with the Kretschmann configuration are used to detect okadaic acid (OA). The okadaic acid–bovine serum albumin bioconjugate (OA-BSA) is immobilized on the graphene layer of the sensors to develop a competitive inhibition immunoassay. The results show that the sensor has a very low limit of detection (LOD) of 1.18 ng/mL for OA, which is about 22.6 times lower than that of a conventional Au biosensor. We believe that such a high-sensitivity SPR biosensor has potential applications for clinical diagnosis and immunoassays.

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Section: Numerical Simulation Design the Proposed Spr Biosensormentioning

confidence: 84%

Performance Enhancement of SPR Biosensor Using Graphene–MoS2 Hybrid Structure

Cai

Wang

et al. 2022

Nanomaterials

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“…This number is the highest we know of. [ 17 ] Dhar et al have succeeded in fabricating 30 graphene layers using the laser ablation method. [ 18 ] The thickness of the monolayer of MoS 2 is 0.65 nm and the refractive index at a wavelength of 670 nm is 5.0805 + 1.1723i.…”

Section: Design Consideration and Theoretical Modelmentioning

confidence: 99%

Molybdenum Disulfide‐based Lossy Mode Resonance Sensors: Uncovering Wider Dynamic Range and High Sensitivity Through Computational Approaches

Nurrohman,

Chiu

2024

Advcd Theory and Sims

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Until now, Surface Plasmon Resonance (SPR) biosensors still rely on gold as their transducer element, and this makes cheap analytical devices difficult to achieve. On the other hand, lossy mode resonance (LMR) sensors offer transducers with more alternative materials due to their flexibility, which can be excited in p‐ and s‐polarized light. In this research it is carried out a numerical investigation using the transfer matrix method on LMR sensor composed of molybdenum disulfide (MoS2) as lossy layer and Cytop as matching layer. The reflectance curves for different thicknesses of MoS2 and Cytop are numerically investigated. The results obtained show that the chip consisting of 250 nm Cytop and 4 layers of MoS2 has a penetration depth 3 times higher than conventional SPR chips. If sensors with two types of polarization are compared, sensors with s‐polarized light have shown higher sensitivity reaching 72.13°/RIU with a wider dynamic range starting from a refractive index of 1.331 to 1.401. In this refractive index range, this sensor has displayed good signal stability where the reduction in resonance dip depth is only ≈6%. These computational results make the proposed structure very promising to be applied in the quantification of biological materials.

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“…Biosensors that incorporate nanocellulose have shown promising potential for the early detection of cancer biomarkers in blood samples. These biosensors are highly sensitive and capable of detecting biomarkers even at very low concentrations [ 36 ]. The use of 2D materials, such as nanocellulose-based materials, has also attracted significant research interest due to their unique properties, including high conductivity, hydrophilicity, and biocompatibility [ 37 ].…”

Section: Advantages Of 2d Materials and Cellulose In Biosensorsmentioning

confidence: 99%

Advancement in Biosensor Technologies of 2D MaterialIntegrated with Cellulose—Physical Properties

Ramezani,

Stiharu,

van de Ven

et al. 2023

Micromachines

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This review paper provides an in-depth analysis of recent advancements in integrating two-dimensional (2D) materials with cellulose to enhance biosensing technology. The incorporation of 2D materials such as graphene and transition metal dichalcogenides, along with nanocellulose, improves the sensitivity, stability, and flexibility of biosensors. Practical applications of these advanced biosensors are explored in fields like medical diagnostics and environmental monitoring. This innovative approach is driving research opportunities and expanding the possibilities for diverse applications in this rapidly evolving field.

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Black phosphorus (BP)–graphene guided-wave surface plasmon resonance (GWSPR) biosensor

Cited by 21 publications

References 40 publications

Performance Enhancement of SPR Biosensor Using Graphene–MoS2 Hybrid Structure

Performance Enhancement of SPR Biosensor Using Graphene–MoS2 Hybrid Structure

Molybdenum Disulfide‐based Lossy Mode Resonance Sensors: Uncovering Wider Dynamic Range and High Sensitivity Through Computational Approaches

Advancement in Biosensor Technologies of 2D MaterialIntegrated with Cellulose—Physical Properties

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