Black Phosphorus (BP) Nanodots for Potential Biomedical Applications

Lee, Hyun Uk; Park, So Young; Lee, Soon Chang; Choi, Seo Young; Seo, Soonjoo; Kim, Hye‐Ran; Won, Jonghan; Choi, Kyuseok; Kang, Kwan Hyoung; Park, Hyun Gyu; Kim, Hee-Sik; An, Ha Rim; Jeong, Kwang-Hun; Lee, Young-Chul; Lee, Jun Young

doi:10.1002/smll.201502756

Cited by 279 publications

(187 citation statements)

References 28 publications

(41 reference statements)

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“…[239] These BP nanoparticles were anchored to magnetic beds and were tested as al abel for the detection of IgG protein in ac ompetitive immunoassay through the hydrogen evolution reaction by using an optimized nanoimpact BP method ( Figure 5D). [241][242][243] Finally,it has been reported that photoexcited BP QDs in the presence of cancer cell lines (C6, HeLa, MDA-MB-231, and MCF7) led to significant cell death, which suggests that BP could have great potential as aa ntitumor photothermal therapy agent. [241][242][243] Reports with cell lines (A549, CHO-K1, COS-7) and model protein (HP35) show lower cytotoxic cell-viability effects than graphene oxide and comparable effects as some TMDs.…”

Section: Angewandte Chemiementioning

confidence: 99%

Black Phosphorus Rediscovered: From Bulk Material to Monolayers

2017

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Phosphorus is a nonmetal with several allotropes, from the highly reactive white phosphorus to the thermodynamically stable black phosphorus (BP) with a puckered orthorhombic layered structure. The bulk form of BP was first synthesized in 1914, but received little attention until it was rediscovered in 2014 as a member of the new wave of 2D layered nanomaterials. BP can be exfoliated to a single sheet that acts as a semiconductor with a tunable direct band gap, a high carrier mobility at room temperature, and an in-plane anisotropy. The development of BP applications is hampered by surface degradation, thus efforts to achieve effective BP passivation are ongoing, such as its integration in van der Waals heterostructures. BP has been tested as a novel nanomaterial in batteries, transistors, sensors, and photonics. This Review begins with the origin of the BP story, following the path from a bulk material to modern few/single layers. The physical and chemical properties are summarized, and the state-of-the-art of BP applications highlighted.

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Section: Angewandte Chemiementioning

confidence: 99%

Black Phosphorus Rediscovered: From Bulk Material to Monolayers

2017

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“…However,f ew preparation approaches andt he long preparation period for BPQDs impede their development and applications. Furthermore, fluorescenceq uantumy ields of the reported BPQDs are relatively low ( % 7.2-11.92 %) at present, [12,13] which precludes their biomedical applications,i ncludingb iolabeling,b ioimaging, and drug delivery.H ence, it is necessary to develop ao ne-step, ultrafast methodt op repareB PQDsw ith a high quantum yield to elaborate on the fluorescencem echanism and for further applicationsi nb iomedical imaging and engineering. Compared with the ultrasonic assisted grinding (UAG), [14] grinding, [15] and hydrothermal methods, [16] the pulsed laser ablation (PLA) method has been widely used to prepare nanomaterials, especially quantum dots, because of simple operation and the short period needed.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Black Phosphorus Quantum Dots with High Quantum Yield by Pulsed Laser Ablation for Cell Bioimaging

Ren

Zhang

2018

Chemistry An Asian Journal

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Black phosphorus quantum dots (BPQDs), with an average diameter of about 6 nm and a height of about 1.1 nm, are successfully synthesized by means of a pulsed laser ablation (PLA) method in isopropyl ether (IPE) solvent. The photoluminescence PL quantum yield of the as-prepared sample is as high as 20.7 %, which is 3 times that of BPQDs prepared by means of probe ultrasonic exfoliation (approximately 7.2 %). The stable and blue-violet PL emission of the BPQDs is observed. It can be elucidated that electrons transit from the LUMO energy level to the HOMO energy level, as well as energy levels below the HOMO (H1 and H2). In addition, BPQDs are also utilized in bioimaging in HeLa cells, showing an intense and stable PL signal and excellent biocompatibility. Hence, this work indicates that the obtained BPQDs with high quantum yield and stable PL emission have great potential for biomedical applications, including biolabeling, bioimaging, and drug delivery.

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“…These materials are widely applied in light-emitting diodes, solar cells, sensing, catalysis, integration in photovoltaic devices, and more recently in biosensing, bioimaging, or medical diagnosis [1,2,3,4,5,6]. …”

Section: Introductionmentioning

confidence: 99%

Transparent Glass-Ceramics Produced by Sol-Gel: A Suitable Alternative for Photonic Materials

et al. 2018

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Transparent glass-ceramics have shown interesting optical properties for several photonic applications. In particular, compositions based on oxide glass matrices with fluoride crystals embedded inside, known as oxyfluoride glass-ceramics, have gained increasing interest in the last few decades. Melt-quenching is still the most used method to prepare these materials but sol-gel has been indicated as a suitable alternative. Many papers have been published since the end of the 1990s, when these materials were prepared by sol-gel for the first time, thus a review of the achievements obtained so far is necessary. In the first part of this paper, a review of transparent sol-gel glass-ceramics is made focusing mainly on oxyfluoride compositions. Many interesting optical results have been obtained but very little innovation of synthesis and processing is found with respect to pioneering papers published 20 years ago. In the second part we describe the improvements in synthesis and processing obtained by the authors during the last five years. The main achievements are the preparation of oxyfluoride glass-ceramics with a much higher fluoride crystal fraction, at least double that reported up to now, and the first synthesis of NaGdF4 glass-ceramics. Moreover, a new SiO2 precursor was introduced in the synthesis, allowing for a reduction in the treatment temperature and favoring hydroxyl group removal. Interesting optical properties demonstrated the incorporation of dopant ions in the fluoride crystals, thus obtaining crystal-like spectra along with higher efficiencies with respect to xerogels, and hence demonstrating that these materials are a suitable alternative for photonic applications.

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Black Phosphorus (BP) Nanodots for Potential Biomedical Applications

Cited by 279 publications

References 28 publications

Black Phosphorus Rediscovered: From Bulk Material to Monolayers

Black Phosphorus Rediscovered: From Bulk Material to Monolayers

Synthesis of Black Phosphorus Quantum Dots with High Quantum Yield by Pulsed Laser Ablation for Cell Bioimaging

Transparent Glass-Ceramics Produced by Sol-Gel: A Suitable Alternative for Photonic Materials

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