Black raspberry extract can lower serum LDL cholesterol via modulation of gut microbial composition and serum bile acid profile in rats fed trimethylamine-N-oxide with a high-fat diet

Lim, Taehwan; Lee, Kiuk; Kim, Ryun Hee; Hyun, Kwang; Koo, Song Yi; Moon, Eun Chae; Hwang, Keum Taek

doi:10.1007/s10068-022-01079-y

Cited by 7 publications

(4 citation statements)

References 38 publications

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“…TDCA and TCA are thought to also have little FXR activity [29]. UDCA, T-α-MCA, T-β-MCA and TUDCA are serum FXR antagonist [30]. And T-β-MCA has fair intestinal stability because of its' resistance to bacterial bile salt hydrolase [31].…”

Section: Discussionmentioning

confidence: 99%

Farnesoid X receptor is inhibited after ileum transposition in diabetic rats: its hypoglycemic effect

Chen¹,

Zhou²,

Xiao³

et al. 2023

Int. J. Med. Sci.

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Background: Aim to investigate bile acid profile changes and the Farnesoid X receptor (FXR) status after ileotransposition (IT), and reveal its possible hypoglycemic mechanism. Methods: Twenty male diabetic rats were randomly assigned into the IT group and the sham IT (SH) group. Bile acid profiles were measured using an ultra-performance liquid chromatography-tandem mass spectrometry. Glucose metabolism was monitored after oral administration of FXR inhibitor and agonist. And the expression of key FXR target genes were measured. Results:The levels of β-muricholic acid (P = 0.047), tauro-α-muricholic acid and tauro-β-muricholic acid (P < 0.001) in plasma in the IT group were higher than those in the SH group, and the levels of taurocholic acid (P = 0.049) and turoursodeoxycholic acid (P = 0.030) were lower than those in the SH group. After inhibition of intestinal FXR, the glucose metabolism in the SH group was improved. When FXR agonist was given, the blood glucose level was increased in both groups. After sacrifice, the levels of glycoursodeoxycholic acid, tauro-α-muricholic acid and tauro-β-muricholic acid in liver and ileum tissues were higher than those in the SH group (P < 0.05), the level of αmuricholic acid (P < 0.001) in liver tissues were lower than that in the SH group. Moreover, the expression of CYP7A1 mRNA (P < 0.001) and FGF15 mRNA (P = 0.001) in the IT group was significantly higher, and the expression of PEPCK mRNA (P = 0.004), SREPB1c mRNA (P = 0.005) and SRB1 mRNA (P = 0.001) were significantly lower than that in the SH group. Conclusions: We demonstrate a remarkable heterogeneity of BA profiles after IT, FXR activation might has a detrimental effect on glucose metabolism.

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Section: Discussionmentioning

confidence: 99%

Farnesoid X receptor is inhibited after ileum transposition in diabetic rats: its hypoglycemic effect

Chen¹,

Zhou²,

Xiao³

et al. 2023

Int. J. Med. Sci.

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“…BRBs have gained recognition for promoting cardiovascular well-being, evidenced by their capacity to lower levels of blood trimethylamine-N-oxide (TMAO), a metabolite produced by gut bacteria [ 77 ]. This metabolite has been linked to cardiovascular disease and was investigated in a study conducted using Sprague-Dawley rats, which were subjected to a high-fat diet supplemented with TMAO.…”

Section: Black Raspberries and Other Diseasesmentioning

confidence: 99%

“…This metabolite has been linked to cardiovascular disease and was investigated in a study conducted using Sprague-Dawley rats, which were subjected to a high-fat diet supplemented with TMAO. Notably, dietary intake of TMAO resulted in elevated serum LDL cholesterol, whereas the consumption of BRB extract contributed to a reduction in this cholesterol biomarker [ 77 ]. In a separate study, it was demonstrated that BRB extract possesses the capability to induce alterations in the gut bacterial community.…”

Section: Black Raspberries and Other Diseasesmentioning

confidence: 99%

Berries vs. Disease: Revenge of the Phytochemicals

Lamenza,

Upadhaya,

Roth

et al. 2024

Pharmaceuticals

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Secondary metabolites and phytochemicals in plant-based diets are known to possess properties that inhibit the development of several diseases including a variety of cancers of the aerodigestive tract. Berries are currently of high interest to researchers due to their high dietary source of phytochemicals. Black raspberries (BRB), Rubus occidentalis, are of special interest due to their rich and diverse composition of phytochemicals. In this review, we present the most up-to-date preclinical and clinical data involving berries and their phytochemicals in the chemoprevention of a variety of cancers and diseases. BRBs possess a variety of health benefits including anti-proliferative properties, anti-inflammatory activity, activation of pro-cell-death pathways, modulation of the immune response, microbiome modulation, reduction in oxidative stress, and many more. However, little has been done in both preclinical and clinical settings on the effects of BRB administration in combination with other cancer therapies currently available for patients. With the high potential for BRBs as chemopreventive agents, there is a need to investigate their potential in combination with other treatments to improve therapeutic efficacy.

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“…Accordingly, EE has the potential to modulate the intestinal microbiota and alleviate inflammation in a mouse model of Parkinson's disease [27]. In this context, EE not only reduces disease markers but also increases bacterial taxa associated with a healthy state, such as the Streptomyces genus and Macellibacteroides, while decreasing those linked to disease, such as the Desulfovibrio and Alistipes genera [22,[27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Environmental Enrichment Prevents Gut Dysbiosis Progression and Enhances Glucose Metabolism in High-Fat Diet-Induced Obese Mice

Manzo,

Gallardo-Becerra,

Díaz de León-Guerrero

et al. 2024

IJMS

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Obesity is a global health concern implicated in numerous chronic degenerative diseases, including type 2 diabetes, dyslipidemia, and neurodegenerative disorders. It is characterized by chronic low-grade inflammation, gut microbiota dysbiosis, insulin resistance, glucose intolerance, and lipid metabolism disturbances. Here, we investigated the therapeutic potential of environmental enrichment (EE) to prevent the progression of gut dysbiosis in mice with high-fat diet (HFD)-induced metabolic syndrome. C57BL/6 male mice with obesity and metabolic syndrome, continuously fed with an HFD, were exposed to EE. We analyzed the gut microbiota of the mice by sequencing the 16s rRNA gene at different intervals, including on day 0 and 12 and 24 weeks after EE exposure. Fasting glucose levels, glucose tolerance, insulin resistance, food intake, weight gain, lipid profile, hepatic steatosis, and inflammatory mediators were evaluated in serum, adipose tissue, and the colon. We demonstrate that EE intervention prevents the progression of HFD-induced dysbiosis, reducing taxa associated with metabolic syndrome (Tepidimicrobium, Acidaminobacteraceae, and Fusibacter) while promoting those linked to healthy physiology (Syntrophococcus sucrumutans, Dehalobacterium, Prevotella, and Butyricimonas). Furthermore, EE enhances intestinal barrier integrity, increases mucin-producing goblet cell population, and upregulates Muc2 expression in the colon. These alterations correlate with reduced systemic lipopolysaccharide levels and attenuated colon inflammation, resulting in normalized glucose metabolism, diminished adipose tissue inflammation, reduced liver steatosis, improved lipid profiles, and a significant reduction in body weight gain despite mice’s continued HFD consumption. Our findings highlight EE as a promising anti-inflammatory strategy for managing obesity-related metabolic dysregulation and suggest its potential in developing probiotics targeting EE-modulated microbial taxa.

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Black raspberry extract can lower serum LDL cholesterol via modulation of gut microbial composition and serum bile acid profile in rats fed trimethylamine-N-oxide with a high-fat diet

Cited by 7 publications

References 38 publications

Farnesoid X receptor is inhibited after ileum transposition in diabetic rats: its hypoglycemic effect

Farnesoid X receptor is inhibited after ileum transposition in diabetic rats: its hypoglycemic effect

Berries vs. Disease: Revenge of the Phytochemicals

Environmental Enrichment Prevents Gut Dysbiosis Progression and Enhances Glucose Metabolism in High-Fat Diet-Induced Obese Mice

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