Black raspberry (
            <i>Rubus occidentalis</i>
            ) attenuates inflammatory markers and vascular endothelial dysfunction in Wistar rats fed a high‐fat diet with fructose solution

Park, Sun Young; Jung, Hwa Jin; Lin, Zhaoyan; Hwang, Keum Taek; Kwak, Ho‐Kyung

doi:10.1111/jfbc.13917

Cited by 5 publications

(2 citation statements)

References 53 publications

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“…Using a DSS-induced model of UC, Montrose et al reported that addition of BRB to the AIN76 basal diet suppressed key pro-inflammatory cytokines, including tumor necrosis factoralpha (TNFα) and interleukin 1-beta (IL1β), thus inhibiting cyclooxygenase 2 (COX2) [23]. Wister rats fed a high-fat diet supplemented with 2.5% or 5% BRB freeze-dried powder for 8 weeks had decreased levels of IL1β, IL6 and COX2 [49]. Multiple studies using the IL10 knockout mouse model for UC showed that supplementing the AIN76A diet with 5% BRB led to decreased inflammatory cell infiltration in colon tissues, which the authors concluded was due to the BRB supplement correcting dysregulated TLR4 in colonocytes, decreasing prostaglandin E2 and inhibiting aberrant epigenetic pathways by decreasing β-catenin translocation levels [50,51].…”

Section: Discussionmentioning

confidence: 99%

Dietary Supplementation with Black Raspberries Altered the Gut Microbiome Composition in a Mouse Model of Colitis-Associated Colorectal Cancer, although with Differing Effects for a Healthy versus a Western Basal Diet

et al. 2022

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Black raspberries (BRB) are rich in anthocyanins with purported anti-inflammatory properties. However, it is not known whether dietary supplementation would ameliorate Western-diet enhanced gut inflammation and colon tumorigenesis. We employed a mouse model of colitis-associated colorectal cancer (CAC) to determine the effects of dietary supplementation with 5 to 10% (w/w) whole, freeze-dried BRB in male C57BL/6J mice fed either a standard healthy diet (AIN93G) or the total Western diet (TWD). In a pilot study, BRB suppressed colitis and colon tumorigenesis while also shifting the composition of the fecal microbiome in favor of taxa with purported health benefits, including Bifidobacterium pseudolongum. In a follow-up experiment using a 2 ´ 2 factorial design with AIN and TWD basal diets with and without 10% (w/w) BRB, supplementation with BRB reduced tumor multiplicity and increased colon length, irrespective of the basal diet, but it did not apparently affect colitis symptoms, colon inflammation or mucosal injury based on histopathological findings. However, BRB intake increased alpha diversity, altered beta diversity and changed the relative abundance of Erysipelotrichaceae, Bifidobacteriaceae, Streptococcaceae, Rikenellaceae, Ruminococcaceae and Akkermansiaceae, among others, of the fecal microbiome. Notably, changes in microbiome profiles were inconsistent with respect to the basal diet consumed. Overall, these studies provide equivocal evidence for in vivo anti-inflammatory effects of BRB on colitis and colon tumorigenesis; yet, BRB supplementation led to dynamic changes in the fecal microbiome composition over the course of disease development.

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Section: Discussionmentioning

confidence: 99%

Dietary Supplementation with Black Raspberries Altered the Gut Microbiome Composition in a Mouse Model of Colitis-Associated Colorectal Cancer, although with Differing Effects for a Healthy versus a Western Basal Diet

et al. 2022

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“…Obesity is frequently assumed to be caused by a high-fat and high-calorie food supply (3). People progressively recognize the harm of the high-fat diet (HFD) and the importance of a scientific diet, therefore they focus on enhancing bodily function through the use of functional foods (4,5). Currently, Chinese herbs such as Panax ginseng, Panax notoginseng, and Chinese yam have been experimentally validated for reducing the risk of cardiovascular disease in animal studies (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Feeding foliar nano-selenium biofortified panax notoginseng could reduce the occurrence of glycolipid metabolism disorder in mice caused by high-fat diets

Dong

Yan

et al. 2022

Front. Nutr.

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Nano-selenium (nano-Se) has been extensively explored as a biostimulant for improving the quality of grain crops. However, there are few reports about the effect on the medicinal components of Chinese herbal medicine cultured with nano-Se. Here, we sprayed nano-Se during the cultivation of Panax notoginseng (SePN), and measured the changes of medicinal components compared with conventional Panax notoginseng (PN). Furthermore, we identified a more pronounced effect of SePN on reducing obesity in animals compared with PN. By measuring antioxidant capacity, histopathology, gene expression related to glycolipid metabolism, and gut microbiota composition, we propose a potential mechanism for SePN to improve animal health. Compared with the control groups, foliar spraying of nano-Se increased saponins contents (Rb2, Rb3, Rc, F2, Rb2, and Rf) in the roots of Panax notoginseng, the content of Rb2 increased by 3.9 times particularly. Interestingly, animal studies indicated that taking selenium-rich Panax notoginseng (SePN) can further ameliorate liver antioxidation (SOD, MDA, and GSH) and enzyme activities involved in glycolipid metabolism (ATGL and PFK). It also relieved inflammation and regulated the expression of genes (MCAD, PPAR-α, and PCSK9) related to fatty acid oxidation. The abundance ratio of Firmicutes/Bacteroides and beneficial bacteria abundance (Bifidobacterium, Butyricimonas, and Parasutterella) in gut microbiota were improved relative to the control. In summary, the application of nano-Se on PN may effectively raise the content of Panax notoginseng saponins (PNS) and immensely lower the risk of metabolic disorders of glycolipids.

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Traditional and Underutilized Fruits and Vegetables for Attaining Zero Hunger

Ritika,

Mansi,

Rizwana

et al. 2024

Advances in Science, Technology &Amp; Innovation

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Black raspberry ( Rubus occidentalis ) attenuates inflammatory markers and vascular endothelial dysfunction in Wistar rats fed a high‐fat diet with fructose solution

Cited by 5 publications

References 53 publications

Dietary Supplementation with Black Raspberries Altered the Gut Microbiome Composition in a Mouse Model of Colitis-Associated Colorectal Cancer, although with Differing Effects for a Healthy versus a Western Basal Diet

Dietary Supplementation with Black Raspberries Altered the Gut Microbiome Composition in a Mouse Model of Colitis-Associated Colorectal Cancer, although with Differing Effects for a Healthy versus a Western Basal Diet

Feeding foliar nano-selenium biofortified panax notoginseng could reduce the occurrence of glycolipid metabolism disorder in mice caused by high-fat diets

Traditional and Underutilized Fruits and Vegetables for Attaining Zero Hunger

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