Black sea cucumber (Holothuria atraJaeger, 1833) rescuesPseudomonas aeruginosa-infectedCaenorhabditis elegans viareduction of pathogen virulence factors and enhancement of host immunity

Lee, Wan-Ting; Tan, Boon-Khai; Eng, Su-Anne; Gan, Chee‐Yuen; Chan, Kit‐Lam; Sim, Yee Kwang; Sulaiman, Shaida Fariza; Shu‐Chien, Alexander Chong

doi:10.1039/c9fo01357a

Cited by 4 publications

(2 citation statements)

References 57 publications

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“…Methanol extracts of sea cucumber Holothuria atra were reported to inhibit the production of P. aeruginosa virulence factors (elastase, protease, pyocyanin) and restore the expression level of host lys-7 in a Pseudomonas aeruginosainfected Caenorhabditis elegans model (Lee et al, 2019).…”

Section: Sea Cucumber Extractsmentioning

confidence: 99%

In Vivo and Clinical Studies of Sea Cucumber-Derived Bioactives for Human Health and Nutrition From 2012-2021

et al. 2022

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Sea cucumbers are amongst the highest value seafoods available commercially, especially in the south-east Asian region, primarily due to their nutritional and health benefits as applied in Traditional Chinese Medicine. While the majority of studies for nutritional products derived from sea cucumber compounds have been conducted in vitro, the number of in vivo and evidence-based human clinical studies are limited. This review has critically assessed the advances in in vivo and clinical studies of sea cucumber-derived bioactives (both extracts and compounds) via a comprehensive literature research on papers published in the last ten years from 2012-2021. Sea cucumber-derived compounds were reported to have the following activities: anticancer, antihyperlipidemic, antihyperglycemic, anti-inflammatory, anticoagulant/antithrombotic, antioxidant, and antihypertension, immunomodulatory, wound healing and as treatments for Alzheimer’s and Parkinson’s diseases. These active compounds include triterpene glycosides (saponins), fucosylated chondroitin sulfate (FCS), cerebrosides, glycosaminoglycan, fucoidan, phospholipids, polysaccharides, peptides, long-chain bases, Frondanol A5, acid mucopolysaccharide, and phosphatidylcholines. Gaps, challenges and future directions have been identified and discussed separately to progress different areas of research and to further scientific validation, development and application of sea cucumbers for human health and nutritional products.

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Section: Sea Cucumber Extractsmentioning

confidence: 99%

In Vivo and Clinical Studies of Sea Cucumber-Derived Bioactives for Human Health and Nutrition From 2012-2021

et al. 2022

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“…It is an edible sea cucumber with a rich content of primarily triterpene glycoside saponins (Grauso et al., 2019). H. atra extract demonstrated various biological effects, including antimicrobial, antiproliferative, cytotoxic, antioxidant, and immunostimulatory (Dakrory et al., 2015; Dhinakaran & Lipton, 2014; Lee et al., 2019; Nursid et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

Seasonal and taxa impact on edible sea cucumber's metabolome and in relation to its cytotoxicity as analyzed via UHPLC/HR‐MS/MS‐based molecular networking and chemometrics

Farag,

El‐Kammar,

Abdelghany

et al. 2024

Food Frontiers

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Sea cucumbers, belonging to class Holothuroidea, are marine invertebrates with substantial bioactive compounds. This study provides the first comparative metabolome profiling of Holothuria atra and Actinopyga crassa sea cucumbers in relation to their season of collection to dissect between winter and summer samples, providing several first‐time reported metabolites as well as the effect of metabolome variation on their cytotoxic activity against colon and prostate cancer cell lines. Ultrahigh‐performance liquid chromatography coupled with high‐resolution mass spectrometry and global natural products social molecular networking followed by multivariate data analysis were employed for metabolite profiling and seasonal biomarker assignment for each species. The cytotoxic activity was evaluated using in vitro assays against prostate and colon cancer cell lines. A total of 113 metabolites were annotated in both species, including 4 organic acids, 21 sulfoquinovosyl glycerol (sulfolipids), 5 alkyl sulfates, 13 sulfated/saponins, 8 sulfated/triterpene mono/di‐glycosides, 10 triterpenes, 13 sulfated/sterols, 32 phospholipids, 4 sphingolipids, and 3 glycerolipids, several of which are new or first‐time reported. Multivariate data analyses revealed lipid accumulation in summer samples versus triterpene and saponin enrichment in winter‐collected samples, particularly in H. atra, rationalizing its potent cytotoxic activity (IC50 6–12 µg/mL) as revealed using a regression model. However, winter‐collected samples of A. crassa are relatively the least abundant in antinutrient saponins, thus considered to have higher food value.

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Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model

Yin,

Meng,

Sun

et al. 2023

Biogerontology

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Black sea cucumber (Holothuria atraJaeger, 1833) rescuesPseudomonas aeruginosa-infectedCaenorhabditis elegans viareduction of pathogen virulence factors and enhancement of host immunity

Abstract: A strategy to circumvent the problem of multidrug resistant pathogens is the discovery of anti-infectives targeting bacterial virulence or host immunity.

Cited by 4 publications

References 57 publications

In Vivo and Clinical Studies of Sea Cucumber-Derived Bioactives for Human Health and Nutrition From 2012-2021

In Vivo and Clinical Studies of Sea Cucumber-Derived Bioactives for Human Health and Nutrition From 2012-2021

Seasonal and taxa impact on edible sea cucumber's metabolome and in relation to its cytotoxicity as analyzed via UHPLC/HR‐MS/MS‐based molecular networking and chemometrics

Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model

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