2018
DOI: 10.1101/366906
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Black swimming dots in cell culture: the identity, detection method and judging criteria

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Cited by 2 publications
(4 citation statements)
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“…2a). When BSD+ extracts were inoculated to BSD− cells, BSD− cells were transformed into BSD+ cells and began to produce BSDs, similar to our previous report [1]. Such a cytopathogenic effect (CPE) would appear in 1~3 days, which might depend on the numbers of the pathogen in different batch of extracts in the repeated experiments.…”
supporting
confidence: 82%
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“…2a). When BSD+ extracts were inoculated to BSD− cells, BSD− cells were transformed into BSD+ cells and began to produce BSDs, similar to our previous report [1]. Such a cytopathogenic effect (CPE) would appear in 1~3 days, which might depend on the numbers of the pathogen in different batch of extracts in the repeated experiments.…”
supporting
confidence: 82%
“…These properties prompt us to speculate that the pathogen of BSDs might be one kind of unidentified virus-like organism. However, the imperfection is that we have not isolated this putative pathogen from BSD+ samples [1]. Here, we report a further investigation of finding the virus-like pathogen in the serum and tissue extracts from BSD+ mice.…”
mentioning
confidence: 90%
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“…Gary et al 9 observed black dot-like contamination in the young adult murine colon epithelial and immorto-min mouse colon epithelial cells. Yang et al 12 . and Xu et al 8 also observed a similar type of black dot contamination in the perivitelline space of zygotes and the A549 cell lines, respectively.…”
Section: Discussionmentioning
confidence: 99%