Black-white differences in postprandial triglyceride response and postheparin lipoprotein lipase and hepatic triglyceride lipase among young men

Friday, Karen E.; Srinivasan, Sathanur R.; Elkasabany, Abdalla; Dong, Caiping; Wattigney, Wendy A.; Dalferes, Edward R.; Berenson, Gerald S.

doi:10.1016/s0026-0495(99)90175-0

Cited by 44 publications

(35 citation statements)

References 42 publications

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“…This effect of ethnicity on PH-LPL activity is concordant with recent findings. 42 In summary, results of the present study indicate that the more favorable lipoprotein profile generally found in abdominally obese black individuals could be explained, at least to a significant extent, by their lower visceral AT accumulation and by their higher PH-LPL activity compared with those values in abdominally obese white individuals.…”

Section: Effect Of Racesupporting

confidence: 48%

Race, Visceral Adipose Tissue, Plasma Lipids, and Lipoprotein Lipase Activity in Men and Women

Després¹,

Couillard

Gagnon

et al. 2000

ATVB

337

118

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Abstract-Abdominal obesity is associated with numerous metabolic alterations, such as hypertriglyceridemia and low levels of high density lipoprotein (HDL) cholesterol. However, compared with abdominally obese white individuals, abdominally obese black individuals have been characterized by higher plasma HDL cholesterol levels, suggesting that the impact of abdominal fat accumulation on the lipoprotein-lipid profile may differ among ethnic groups. Therefore, we have compared the associations between body fatness, visceral adipose tissue (AT) accumulation, and metabolic risk variables in a sample of 247 white men and 240 white women versus a sample of 93 black men and 143 black women. Although no difference in mean total body fatness was found between the 2 race groups, white men had higher levels of visceral AT than did black men (PϽ0.001). Despite the fact that black women had a greater body fat content than did white women, black women had levels of visceral AT that were similar to those of white women, suggesting a lower susceptibility to visceral obesity in black women. This lower accumulation of visceral AT in blacks was accompanied by significantly reduced apolipoprotein B concentrations and ratios of total cholesterol to HDL cholesterol as well as higher plasma HDL cholesterol levels (PϽ0.05) compared with those values in whites. Irrespective of sex, higher postheparin plasma hepatic lipase (HL) and lower lipoprotein lipase (LPL) activities were found in whites, resulting in an HL/LPL ratio that was twice as high in whites as in blacks (PϽ0.005). Although differences in lipoprotein-lipid levels were noted between whites and blacks, results from multiple regression analyses revealed that after control for morphometric and metabolic variables of the study (body fat mass, visceral AT, LPL, HL, and age), ethnicity had, per se, only a minor contribution to the variance in plasma lipoprotein levels. Thus, our results suggest that the higher plasma HDL cholesterol levels and the generally more cardioprotective plasma lipoprotein profile found in abdominally obese black versus white individuals are explained, at least to a certain extent, by a lower visceral AT deposition and a higher plasma LPL activity in black individuals. bdominal obesity has been shown to be associated with the features of the insulin resistance-dyslipidemic syndrome, especially among patients characterized by an excess of visceral adipose tissue (AT). 1-5 Race differences have been reported in the relationship of body fatness to visceral AT accumulation, with whites being more prone to visceral AT deposition than blacks for any level of total body fat. 6 -8 We have also previously shown that excess visceral AT accumulation was related to reduced plasma HDL cholesterol levels in obese white subjects. 9 Because obese black individuals have been characterized by higher plasma HDL cholesterol levels than obese white individuals, 6,7,10 we have tested the hypothesis that the lower accumulation of visceral AT could be responsible for the higher ...

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Section: Effect Of Racesupporting

confidence: 48%

Race, Visceral Adipose Tissue, Plasma Lipids, and Lipoprotein Lipase Activity in Men and Women

Després¹,

Couillard

Gagnon

et al. 2000

ATVB

337

118

View full text Add to dashboard Cite

show abstract

“…Many studies have demonstrated that African Americans have higher fasting and postprandial PH-LPL activities than Caucasians [23,24,29]. Because high LPL levels lead to low TG levels, high LPL levels in African Americans may be cardioprotective.…”

Section: Discussionmentioning

confidence: 99%

Normal triglyceride levels despite insulin resistance in African Americans: role of lipoprotein lipase

et al. 2005

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“…It is possible that elevations in postprandial lipemia might precede changes in the fasting lipid and lipoprotein values and be more sensitive indicators of genetic predisposition to obesity, diabetes, and atherosclerosis. In addition to studies in children, the essential work of documenting an effect of ethnicity on the postprandial response has also begun [9]. Standard meal tests revealed that white men had higher postprandial TAG responses than black men, although in both groups fasting TAG was independently (positively) associated with the 2-hour incremental increase in TAG.…”

Section: Human Variability and Postprandial Lipoprotein Metabolismmentioning

confidence: 99%

“…The mean lipoprotein lipase activity of the black men was significantly higher. The authors speculated that compared with whites, blacks may have a more efficient lipid-clearing mechanism, which could explain the differences in lipoproteins found in the black and white populations at large [9].…”

Section: Human Variability and Postprandial Lipoprotein Metabolismmentioning

confidence: 99%

Recent findings in the study of postprandial lipemia

Parks

2001

Curr Atheroscler Rep

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The study of postprandial metabolism is in the early stages compared with other areas of atherosclerosis research. Recent advances in postprandial research have included improvements in methodology and the investigation of factors that modulate the lipemic response to a meal. Enough studies have now been performed that normal ranges have been identified for blood triacylglycerol (TAG) concentrations that occur after a healthy patient consumes a standardized-mixed meal or a high-fat shake designed to elicit lipemia. Typical postprandial concentrations of other metabolites, such as apolipoproteins B48 and B100 or gastrointestinal hormones (eg, cholecystokinin), have not been studied sufficiently to be able to qualify what represents a standard postprandial response. The method of data analysis is also a key point to consider. Data from children are now becoming available, and the specific effects of ethnicity have just begun to be explored. New areas of study include the effects of different fatty acids (monosaturates or polyunsaturates), the sources of chylomicron lipids (dietary TAG and cholesterol versus that newly synthesized in the body), and the effects of alcoholic beverages consumed with the meal. Variables that can also affect the results of a meal test are under investigation. These include the type of food that is consumed the day before the meal test, the time of day the test is performed, and the palatability of the food. Given solid evidence that delayed postprandial lipemia is an independent risk factor for coronary heart disease, future scientific investigation in the area of postprandial metabolism is likely to yield discoveries that will significantly contribute to advancements in disease treatment.

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Black-white differences in postprandial triglyceride response and postheparin lipoprotein lipase and hepatic triglyceride lipase among young men

Cited by 44 publications

References 42 publications

Race, Visceral Adipose Tissue, Plasma Lipids, and Lipoprotein Lipase Activity in Men and Women

Race, Visceral Adipose Tissue, Plasma Lipids, and Lipoprotein Lipase Activity in Men and Women

Normal triglyceride levels despite insulin resistance in African Americans: role of lipoprotein lipase

Recent findings in the study of postprandial lipemia

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