Blackberry (Rubus spp.): a pH-dependent oral contrast medium for gastrointestinal tract images by magnetic resonance imaging

Espinosa, María G.; Sosa, M.; León-Rodríguez, Luis M. De; Córdova, T.; Bernal‐Alvarado, J.; Ávila-Rodríguez, Mario; Reyes-Aguilera, J. Antonio; Ortiz, Juan José; Barrios, Fernando A.

doi:10.1016/j.mri.2005.10.026

Cited by 15 publications

(17 citation statements)

References 30 publications

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“…wild mulberry was the fruit with the highest iron content. Mulberry was the fruit that presented the highest negative contrast; however, just as acai and blueberry, it is not very much used in our market, which makes them less accessible and more expensive to be used routinely in the clinical practice in MRCP exams [22]. In the present study, the use of pineapple juice with gadopentetate dimeglumine as a negative oral contrast agent was efficient and convenient for the MRCP exam.…”

Section: Discussionmentioning

confidence: 61%

“…In order to minimize this problem, patients performing the MRCP exam are asked to fast for approximately 4 h before the exam, and a negative oral contrast agent is administered before the exam [26][27][28]. Several studies have used both artificial and natural exogenous agents as contrast; these are administered orally to allow for a better visualization of bile ducts [22]. Coppens et al [23] reported that manganese was the substance responsible for the signal alteration caused by contrast agents.…”

Section: Discussionmentioning

confidence: 99%

“…Artificial oral contrast agents are not well tolerated by patients, for they produce adverse effects, such as teeth stains, gastric irritation, vomiting, diarrhea, and constipation [21,22]. These adverse effects are not seen in the use of natural oral contrast agents, such as blueberry, mulberry, pineapple, and acai juices, as well as water and tea [21].…”

Section: Discussionmentioning

confidence: 99%

“…In the quantitative analysis, the signal loss in the stomach and duodenum was measured and was, respectively, 96% ± 5% and 90% ± 16%, showing that it is highly effective as a negative contrast agent. In 2006, Espinosa et al [22] also found pineapple to be the fruit that contains the highest concentration of manganese when compared with other fruits analyzed in vitro.…”

Section: Introductionmentioning

confidence: 98%

“…Several studies have used contrast agents to suppress the signal of the digestive tube [20][21][22]. The ideal oral contrast agent for MR should have a good acceptance by patients, have a uniform distribution in the lumen of the digestive tract, should not be diluted during its trajectory, should not be toxic, should not stimulate peristalsis, and should have an acceptable cost [21].…”

Section: Introductionmentioning

confidence: 99%

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Use of pineapple juice with gadopentetate dimeglumine as a negative oral contrast for magnetic resonance cholangiopancreatography: a multicentric study

2011

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We evaluated the efficacy of pineapple juice with gadopentetate dimeglumine as a negative oral contrast agent for magnetic resonance cholangiopancreatography (MRCP). Images were obtained before and after the intake of a negative oral contrast agent. Images obtained from six different areas of the biliary tree were analyzed by three different radiologists, who were blind to the exams; scores regarding image quality were given to each area. The statistical analysis showed a significant difference between images before and after the use of the contrast agent (P < 0.001) for the three radiologists (R1-R3). Mean scores given by radiologists before the intake of the contrast agent were 2.49 ± 0.42 (R1), 2.62 ± 0.32 (R2), and 2.22 ± 0.46 (R3). After the intake, mean scores were 3.38 ± 0.62 (R1), 3.48 ± 0.55 (R2), and 2.89 ± 0.69 (R3). The ducts that showed the highest scores were the common bile duct and duct of Wirsung, the distal portion of the common bile duct and the cystic duct. We suggest herein that the contrast agent pineapple juice with gadopentate dimeglumine constitutes an efficient negative oral contrast agent for MRCP, for it efficiently eliminates the signal of the digestive tube in MRCP images.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Use of pineapple juice with gadopentetate dimeglumine as a negative oral contrast for magnetic resonance cholangiopancreatography: a multicentric study

2011

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Ingestible Contrast Agents for Gastrointestinal Imaging

2019

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Gastrointestinal (GI) ailments cover a wide variety of diseases involving the esophagus, stomach, small intestine, large intestine, and rectum. They bring about many inconveniences in daily life in chronic diseases and can even be life threatening in acute cases. Rapid and safe detection approaches are essential for early diagnosis and timely management. Contrast agents for GI imaging can enhance contrast to distinguish abnormal lesions from normal structures. Computed tomography and magnetic resonance imaging are two important diagnostic tools for the evaluation of GI conditions. This review mainly involves several common GI diseases, including inflammatory diseases, intestinal tumors, diarrhea, constipation, and gastroesophageal reflux diseases. Selected contrast agents, such as barium sulfate, iodine‐based agents, gadolinium‐based agents, and others, are summarized. Going forward, continued endeavors are being made to develop more emerging contrast agents for other imaging modalities.

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Performance of a new natural oral contrast agent (LumiVision®) in dynamic MR swallowing

et al. 2021

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Objectives To evaluate image quality by first use of LumiVision® in dynamic MR swallowing, a contrast medium consisting of biological substances versus a gadolinium-buttermilk mixture in patients who underwent Nissen fundoplication due to gastroesophageal reflux disease (GERD). Methods The protocol of this retrospective study was approved by the local Institutional Review Board. A hundred twenty-nine patients (146 examinations) underwent a dynamic MR swallowing study (at 1.5 T or 3.0 T) and received an oral contrast agent. Two readers evaluated the distention of the esophagus, contrast, and traceability of the bolus in a 3-point scale. A steady-state coherent sequence (B-FFE, TrueFISP) was used. The patients were divided into 3 different groups: 53 patients received gadolinium chelate (Dotarem®)–buttermilk mixture (GBM) in a dilution of 1:40 as an oral contrast agent; 44 patients received LumiVision® water mixture (LWM) in a dilution of 1:1 and 49 patients received LumiVision® (L) undiluted. Results GBM showed significantly better results in overall evaluation for both readers in contrast to LWM (p = .003, p = .002). L also reached significantly better results in overall evaluation than LWM in both readers (p = .004, p = .042). There was no significant difference in the overall evaluation between L and GBM (p = .914, p = .376).According to Landis and Koch, interobserver agreement was “substantial” (Cohen’s kappa = 0.738) between both readers. Conclusion LumiVision® undiluted showed equal image quality compared to gadolinium-buttermilk mixture. The constellation of LumiVision® water mixture led to a clearly negative result in relation to the image quality compared to LumiVision® undiluted. Therefore, oral ingestion of LumiVision® undiluted is recommended for MR swallowing examinations. Key Points • LumiVision® undiluted shows significantly better image quality in comparison to LumiVision® diluted in oral application in swallowing MRI. • LumiVision® undiluted shows equal image quality in comparison to gadolinium-buttermilk mixture in oral application. • Oral ingestion of LumiVision® undiluted can replace gadolinium-buttermilk mixture in oral MR examinations.

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Blackberry (Rubus spp.): a pH-dependent oral contrast medium for gastrointestinal tract images by magnetic resonance imaging

Cited by 15 publications

References 30 publications

Use of pineapple juice with gadopentetate dimeglumine as a negative oral contrast for magnetic resonance cholangiopancreatography: a multicentric study

Use of pineapple juice with gadopentetate dimeglumine as a negative oral contrast for magnetic resonance cholangiopancreatography: a multicentric study

Ingestible Contrast Agents for Gastrointestinal Imaging

Performance of a new natural oral contrast agent (LumiVision®) in dynamic MR swallowing

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