Bladder agenesis

Akdaş, Atıf; Işeri, C.; Özgür, S.; Kirkali, Ziya

doi:10.1007/bf02549513

Cited by 8 publications

(10 citation statements)

References 3 publications

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“…Bladder agenesis is a rare congenital anomaly in viable infants. Most of the reported cases were from autopsy series of stillbirths with multiple congenital anomalies, because unless the ureters are able to drain to an ectopic location such as the vagina [20,21], which occurred in the two oldest surviving patients reported, bladder agenesis is incompatible with life. In the present animal model, there was complete absence of the bladder, which contrasted with earlier studies by Thompson et al.…”

Section: Discussionmentioning

confidence: 99%

Cloacal and urogenital malformations in adriamycin‐exposed rat fetuses

Liu

Hutson

2000

BJU International

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Objectives To determine the spectrum of cloacal and urogenital malformations in rat fetuses prenatally exposed to adriamycin, which causes abnormalities that strongly resemble the VATER association (vertebral defects, anal atresia, tracheo-oesophageal ®stula with oesophageal atresia, renal defects and radial limb dysplasia) in humans, and to evaluate how closely such anomalies resemble those seen in humans. Materials and methods Timed-pregnant rats were injected intraperitoneally with adriamycin at 6±9 days of gestation; a control group received saline only. Fetuses (35 treated and 30 control) were recovered at 21 days of gestation, and examined macroscopically and microscopically for cloacal and urogenital abnormalities. Results All the treated fetuses had no bladders and severe hydroureter/hydronephrosis on one or both sides. Male fetuses had a proximal blind-ending urethra communicating with dilated ureters and giving rise to vasa. Female fetuses had a persistent urogenital sinus communicating with the ureters and cervix/uterus; 57% of the treated group had an imperforate anus and some had recto-urethral ®stulae (males) or rectourogenital ®stulae (females). Conclusion Rat fetuses exposed to adriamycin have a spectrum of cloacal and urogenital anomalies (predominantly no bladder) which is more severe than those of the human VATER association. Nonetheless, this is an excellent animal model for the study of genitourinary embryology, especially bladder development.

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Section: Discussionmentioning

confidence: 99%

Cloacal and urogenital malformations in adriamycin‐exposed rat fetuses

Liu

Hutson

2000

BJU International

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“…Several cases of bladder agenesis and an extensive array of ureteric abnormalities have been reported in the literature [1][2][3]. In bladder hypoplasia, it is believed that inadequate filling with urine results in underdevelopment of the fetal bladder.…”

Section: Discussionmentioning

confidence: 97%

Management of a hypoplastic lower urinary tract: a case report

Alagaratnam

Manoharan

Mushtaq

2011

Journal of Pediatric Surgery

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“…The prenatal presentation was due to oligohydramnios, and the definitive diagnosis was after birth. (2) Late presentation: beyond the first year of life, usually with incontinence [ 2 , 3 , 5 , 11 , 15 , 18 , 37 , 40 , 52 , 53 ], urinary tract infection (UTI) [ 1 , 6 , 30 , 34 , 43 ], or both [ 13 , 27 , 30 , 33 , 35 , 42 ].…”

Section: Reviewmentioning

confidence: 99%

“…Nazer et al’s subject had a low bifurcation of the aorta, and the internal iliac arteries were absent [ 51 ]. Akdas et al found that the subject had an absent right renal artery [ 11 ]. Lastly, an esophageal ring is formed by the left aortic arch and a posteriorly coursing aberrant right subclavian artery [ 46 ].…”

Section: Reviewmentioning

confidence: 99%

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Bladder Agenesis: A Systematic Review

Yahya

2023

Cureus

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Bladder agenesis is a rare congenital deformity characterized by the absence of the bladder. It is primarily observed in postmortem dissections of stillbirths rather than live births. The condition is often associated with other congenital anomalies, leading to the hypothesis that most affected fetuses do not survive to term. However, the exact cause and specific associated anomalies remain unclear and poorly described in the literature. The limited mention of bladder agenesis in textbooks and literature underscores the importance of creating a comprehensive source for future research in this field. Therefore, our objective is to collect and analyze data on bladder agenesis, focusing on associated anomalies and potential causes, to enhance our understanding of the condition. We conducted a thorough review of reports collected from three databases, Google Scholar, PubMed, and Science Direct, last searched on July 30, 2023, starting with 327 reports. Excluding duplicates and records written in languages other than English, veterinary studies, irrelevant reports, or stillbirths. Inclusion criteria were the following: cases must have proven bladder agenesis, not hypoplasia, and must have most of the information, including the age of diagnosis, presenting symptoms, gender, associated anomalies, and management or outcome of the patient. A quality assessment was conducted according to the Joanna Briggs Institute checklist for case reports. A total of 65 case reports from 56 articles were included in the review. Through our manual analysis, we documented a wild array of malformations associated with bladder agenesis. Among the reports reviewed, 93% exhibited urinary system malformations beside bladder agenesis, 77% were found to have reproductive malformations, 44% had gastrointestinal anomalies, 38% showed musculoskeletal malformations, 28% had cardiac malformations, and another 28% had vascular anomalies. The overall mortality rate was 38%, with a higher rate of 74% for males compared to 20% for females. By collating and analyzing those case reports, we aim to contribute to a better understanding of bladder agenesis and its associated anomalies, facilitating further investigations and advancements in the field.

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Bladder agenesis

Abstract: Agenesis of the bladder is an extremely rare anomaly with only approximately 40 such cases reported in the literature. We report on a 30-year-old female patient who also had right renal agenesis.

Cited by 8 publications

References 3 publications

Cloacal and urogenital malformations in adriamycin‐exposed rat fetuses

Cloacal and urogenital malformations in adriamycin‐exposed rat fetuses

Management of a hypoplastic lower urinary tract: a case report

Bladder Agenesis: A Systematic Review

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