Bladder Augmentation (Enterocystoplasty): the Current State of a Historic Operation

Budzyn, Jeffrey; Trinh, Hamilton; Raffee, Samantha; Atiemo, Humphrey

doi:10.1007/s11934-019-0919-z

Cited by 22 publications

(14 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ileocystoplasty, the most common procedure for bladder augmentation in human medicine, for example, has been associated with hypokalaemic metabolic acidosis, electrolyte abnormalities (i.e., hyperchloremia) and vitamin deficiency. Instead, large intestinal segments such as the colon (second most common procedure) and caecum cause higher rates of UTI and diarrhoea, respectively 5 . Also, jejunal augmentation cystoplasty in humans can cause electrolyte abnormalities, although the incidence is considered low (i.e., 25%) and potentially minimized by giving oral electrolyte supplementation 19 .…”

Section: Discussionmentioning

confidence: 99%

“…Instead, large intestinal segments such as the colon (second most common procedure) and caecum cause higher rates of UTI and diarrhoea, respectively. 5 Also, jejunal augmentation cystoplasty in humans can cause electrolyte abnormalities, although the incidence is considered low (i.e., 25%) and potentially minimized by giving oral electrolyte supplementation. 19 Due to the routine use in people, this surgical treatment option has also started to be performed in dogs with extensive bladder necrosis.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4] Recurrent urinary tract infection (UTI), persistent microscopic haematuria, hypokalaemia, hypochloraemia, metabolic acidosis, urinary calculi formation, diarrhoea and bladder perforation are commonly described complications after surgery in humans. 5 Currently, there is a dearth of evidence in the veterinary literature to guide the best surgical approach or outcome regarding the most recommended gastrointestinal segment that could be potentially associated with less short-and long-term post-operative complications. In the case report presented here, a jejunal segment was used for the bladder augmentation because of extensive bladder necrosis, and both the patient's in-hospital and post-discharge progression were evaluated.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Augmentation enterocystoplasty in a polytrauma dog with extensive bladder necrosis

Gonçalves

Wade

Fransson

et al. 2021

Vet Record Case Reports

View full text Add to dashboard Cite

An 11‐year‐old male castrated Terrier was referred for multiple pelvic fractures following vehicular trauma. Pertinent clinical findings included a painful abdomen, non‐ambulatory paraparesis, absent anal tone and perineal reflex and urinary incontinence. Relevant findings on abdominal CT were pelvic fractures, prepubic tendon avulsion and retroflexed urinary bladder. A urinary catheter was placed to decompress the bladder, and a positive contrast cystourethrogram showed no evidence of leakage. Intraoperatively, it was found that approximately 90% of the bladder was necrotic; both ureters, prostatic urethra and the sphincter appeared viable. An enterocystoplasty was performed using a vascularized jejunal segment, made into an enteric pouch, and sutured to the remainder of the viable bladder. Ureteral partial obstruction, oliguria and UTI were short‐term complications; the patient also had persistent urinary incontinence. Enterocystoplasty is a surgical procedure that can be considered in patients with extensive bladder necrosis after carefully considering the possible short and long‐term complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Augmentation enterocystoplasty in a polytrauma dog with extensive bladder necrosis

Gonçalves

Wade

Fransson

et al. 2021

Vet Record Case Reports

View full text Add to dashboard Cite

show abstract

“…However, short- and long-term complications often present since the leading role of the intestinal tissue is to absorb nutrients, whereas the role of the bladder is to protect against urine toxicity[ 16 ]. Thus, malignancies, metabolic complications such as reabsorption of acid, electrolyte disturbance and mucus retention, bladder calculi, bladder perforation, upper tract deterioration and chronic infections are commonly affecting patients that underwent enterocystoplasty[ 17 , 18 ].…”

Section: Anatomy Pathologies and Current Treatmentsmentioning

confidence: 99%

Considerations for the clinical use of stem cells in genitourinary regenerative medicine

Caneparo

Sorroza-Martinez

Chabaud

et al. 2021

WJSC

View full text Add to dashboard Cite

The genitourinary tract can be affected by several pathologies which require repair or replacement to recover biological functions. Current therapeutic strategies are challenged by a growing shortage of adequate tissues. Therefore, new options must be considered for the treatment of patients, with the use of stem cells (SCs) being attractive. Two different strategies can be derived from stem cell use: Cell therapy and tissue therapy, mainly through tissue engineering. The recent advances using these approaches are described in this review, with a focus on stromal/mesenchymal cells found in adipose tissue. Indeed, the accessibility, high yield at harvest as well as anti-fibrotic, immunomodulatory and proangiogenic properties make adipose-derived stromal/SCs promising alternatives to the therapies currently offered to patients. Finally, an innovative technique allowing tissue reconstruction without exogenous material, the self-assembly approach, will be presented. Despite advances, more studies are needed to translate such approaches from the bench to clinics in urology. For the 21 st century, cell and tissue therapies based on SCs are certainly the future of genitourinary regenerative medicine.

show abstract

“…Bladder contracture or defects caused by numerous diseases require augmentation or replacement of the original bladder, and thus far, the gold standard of treatment is enterocystoplasty. 1 Nevertheless, the main function of the bowel mucosa is reabsorption and not storage. The differences in the microstructures between the bowel and urothelium may cause many complications, such as metabolic imbalance, lithogenesis, ileus, infection, and even malignant transformation.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic potential of adipose-derived mesenchymal stem cell exosomes in tissue-engineered bladders

et al. 2021

View full text Add to dashboard Cite

Mesenchymal stem cells (MSCs) are a therapeutic tool for tissue engineering. However, many studies have recently shown that the therapeutic effects of MSCs are mediated by paracrine signaling and their secretory factors rather than their multidirectional differentiation ability. Exosomes isolated from the conditioned medium of MSCs are considered the main intercellular communication medium between MSCs and their target cells. Exosomes have been utilized in a novel cell-free therapy strategy that has attracted much attention. In this study, we evaluated the effects of a new cell-free tissue-engineered bladder (bladder acellular matrix combined with adipose-derived mesenchymal stem cell exosomes (AMEs)) in vivo and in vitro to prove that AMEs promoted tissue regeneration and functional recovery in a rat bladder replacement model.

show abstract

Bladder Augmentation (Enterocystoplasty): the Current State of a Historic Operation

Cited by 22 publications

References 71 publications

Augmentation enterocystoplasty in a polytrauma dog with extensive bladder necrosis

Augmentation enterocystoplasty in a polytrauma dog with extensive bladder necrosis

Considerations for the clinical use of stem cells in genitourinary regenerative medicine

Therapeutic potential of adipose-derived mesenchymal stem cell exosomes in tissue-engineered bladders

Contact Info

Product

Resources

About