Bladder Cancer

Almousa, Sameh; Casals, Randy; Langsten, Kendall; Said, Neveen

doi:10.1016/b978-0-12-820472-6.00040-2

Comprehensive Pharmacology 2022

DOI: 10.1016/b978-0-12-820472-6.00040-2

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Bladder Cancer

Sameh Almousa

Randy Casals

Kendall Langsten

et al.

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Cited by 1 publication

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Mannose‐targeting Concanavalin A−Epirubicin Conjugate for Targeted Intravesical Chemotherapy of Bladder Cancer

Huo

Zhang

et al. 2022

Chemistry An Asian Journal

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Intravesical instillation of chemotherapeutic drugs such as epirubicin (EPI) is routinely used to prevent tumor recurrence and progression after transurethral resection of bladder tumor. However, the lack of tumor selectivity often causes severe damage to normal bladder urothelium leading to intolerable side effects. Here, we analyzed abnormal changes in glycosylation in bladder cancer and identified mannose as the most aberrantly expressed glycan on the surface of bladder cancer cell lines and human bladder tumor tissues. We then constructed a lectin-drug conjugate by linking concanavalin A (ConA) -a lectin that specifically binds to mannose, with EPI through a pH-sensitive linker. This ConAÀ EPI conjugate conferred EPI with mannose-targeting ability and selectively internalized cancer cells in vitro. This conjugate showed selective cytotoxicity to cancer cells in vitro and better antitumor activity in an orthotopic mouse model of bladder cancer. Our lectin-drug conjugation strategy makes targeted intravesical chemotherapy of bladder cancer possible.

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Mannose‐targeting Concanavalin A−Epirubicin Conjugate for Targeted Intravesical Chemotherapy of Bladder Cancer

Huo

Zhang

et al. 2022

Chemistry An Asian Journal

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Bladder Cancer

Cited by 1 publication

References 202 publications

Mannose‐targeting Concanavalin A−Epirubicin Conjugate for Targeted Intravesical Chemotherapy of Bladder Cancer

Mannose‐targeting Concanavalin A−Epirubicin Conjugate for Targeted Intravesical Chemotherapy of Bladder Cancer

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