Bladder cancer as a prescribed industrial disease: a guide for clinicians.

Bladder tumours among rodent operatives handling ANTU.

“…The 83-year-old man dying in the 1971-5 period may also have worked for the Ministry, but this remains unconfirmed. The search for deaths among the 360 rodent operatives exposed to ANTU listed by local authorities revealed only four cases already known from other sources (5,6,8,10); had this source alone been used, the deaths of cases 1, 2, and 9 would have been missed. In addition, one local authority reported a current employee to have been treated for a bladder tumour (11), but this man had had only slight exposure to ANTU and his tumour was probably attributable to earlier exposure to carcinogens in a chemical factory.…”

Association of N-Acetyltransferase Polymorphism and Environmental Factors with Bladder Carcinogenesis (1)

“…Since the end of the 19th century when clinical obser vations of bladder cancer patients in the German dye industry gave the first evidence that occupational and environmental chemicals are responsible in a high num ber of disease incidences, several investigations have shown the outstanding role of arylamines and a number of related compounds in human bladder carcinogenesis [1][2][3]. Accordingly, several occupations in the chemical industry including dye, textile, rubber, and aluminium workers as well as painters and hairdressers have been shown to be at high risk for bladder cancer [4,5], Estimations for occupational involvement in bladder cancer incidence vary from 10 to 50% depending on local environments.…”