Bladder cancer in patients with neurogenic bladder disorder: a comparative study of different etiologies

Mühlbauer, Julia; Klotz, David; Büttner, Sylvia; Stein, Raimund; Younsi, Nina

doi:10.1007/s00345-021-03922-z

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…Die Datenlage bei Patienten mit Morbus Parkinson oder anderen neurologischen Erkrankungen ist völlig unzureichend (Übersicht bei [55]). Eine aktuelle Arbeit an 23 Harnblasenkarzinompatienten mit NLUTD unterschiedlicher Ätiologie [56] bestätigte auch für Patienten mit zentralen Läsionen des Nervensystems (Schlaganfall, Morbus Parkinson, MS) oder peripheren Läsionen (Polyneuropathie) mit querschnittgelähmten Patienten vergleichbar ungünstige onkologische Parameter und eine entsprechend schlechte Prognose.…”

Section: Harnblasenkarzinom Bei Anderen Neurologischen Erkrankungenunclassified

Onkologische Relevanz neurourologischer Erkrankungen

Böthig,

Schöps,

Kowald

et al. 2024

Aktuelle Urol

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Zusammenfassung Von wenigen Ausnahmen abgesehen ist derzeit die Evidenz wissenschaftlicher Erkenntnisse zur Frage der onkologischen Relevanz neurourologischer Erkrankungen noch gering. Am besten erforscht ist der Zusammenhang zwischen einer langjährigen bestehenden Querschnittlähmung mit ihren Folgen für den unteren Harntrakt und dem Auftreten eines Harnblasenkarzinoms. Diese Karzinome unterscheiden sich vielfältig von Harnblasenkarzinomen bei Patienten ohne Querschnittlähmung: Die Patienten sind im Durchschnitt 20 Jahre jünger, die Tumoren sind sehr häufig bereits muskelinvasiv und schlecht differenziert mit einem hohen Anteil an Plattenepithelkarzinomen, die Prognose ist schlecht. Diese Charakteristika treten auch bei querschnittgelähmten Patienten ohne Dauerkatheterableitung der Harnblase auf. Obwohl der pathophysiologische Zusammenhang im Detail noch ungeklärt ist, so scheint doch der entscheidende Link zwischen einer Querschnittlähmung und dem Auftreten eines Harnblasenkarzinoms das Vorliegen einer neurogenen Blase zu sein. Pathologische Druckverhältnisse in der Harnblase und häufige Harnwegsinfekte bzw. asymptomatische Bakteriurien infolge der neurogenen Fehlsteuerung der Harnblase könnten die pathophysiologisch entscheidenden Faktoren darstellen. Insofern stellt das Harnblasenkarzinom bei chronisch querschnittgelähmten Patienten einen Modelltumor nach einer Denervierung dar. Die klinisch wichtige Frage eines Screenings erfordert zukünftige interdisziplinäre Forschungsansätze.

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Section: Harnblasenkarzinom Bei Anderen Neurologischen Erkrankungenunclassified

Onkologische Relevanz neurourologischer Erkrankungen

Böthig,

Schöps,

Kowald

et al. 2024

Aktuelle Urol

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“…While, diet may also increase the occurrence of bladder cancer, as Aveta et al found that "red meat" and "processed meat" may be positively associated with bladder cancer risk [19]. In individuals with neurogenic bladder resulting from SCI, healthcare facilities often use catheters or suprapubic cystostomies for extended durations, which, along with the factors mentioned above, have been linked to chronic bladder inflammation and an increased risk of BC [20,21]. Furthermore, the prolonged use of catheters can lead to intricate urinary tract infections and the formation of bladder stones, increasing the probability of developing BC (Fig.…”

Section: Mechanism Of Occurrencementioning

confidence: 99%

Clinical characteristics and molecular mechanisms underlying bladder cancer in individuals with spinal cord injury: a systematic review

Wang,

Chen

et al. 2024

BMC Urol

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Background Patients with spinal cord injury have a relatively high risk for bladder cancer and often complicated with bladder cancer in advanced stages, and the degree of aggressiveness of malignancy is high. Most of the literature is based on disease clinical features while, our study reviews the clinical characteristics and molecular mechanisms of spinal cord injury patients with bladder cancer, so that it might help clinicians better recognize and manage these patients. Method We searched PubMed, Web of Science and Embase, using retrieval type like (“Neurogenic Lower Urinary Tract Dysfunction” OR “Spinal cord injury” OR “Spinal Cord Trauma”) AND (“bladder cancer” OR “bladder neoplasm” OR “bladder carcinoma” OR “Urinary Bladder Neoplasms” OR “Bladder Tumor”). In Web of Science, the retrieval type was searched as “Topic”, and in PubMed and Embase, as “All Field”. The methodological quality of eligible studies and their risk of bias were assessed using the Newcastle-Ottawa scale. This article is registered in PROSPERO with the CBD number: CRD42024508514. Result In WOS, we searched 219 related papers, in PubMed, 122 and in Embase, 363. Thus, a total of 254 articles were included after passing the screening, within a time range between 1960 and 2023. A comprehensive analysis of the data showed that the mortality and incidence rates of bladder cancer in spinal cord injury patients were higher than that of the general population, and the most frequent pathological type was squamous cell carcinoma. In parallel to long-term urinary tract infection and indwelling catheterization, the role of molecules such as NO, MiR 1949 and Rb 1. was found to be crucial pathogenetically. Conclusion This review highlights the risk of bladder cancer in SCI patients, comprehensively addressing the clinical characteristics and related molecular mechanisms. However, given that there are few studies on the molecular mechanisms of bladder cancer in spinal cord injury, further research is needed to expand the understanding of the disease.

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“…Neurogenic bladder (NB), a lower urinary tract dysfunction caused by damage to the central nervous system or peripheral nervous system that controls voiding function, usually occurs in patients with neurological lesions or trauma (1). Diabetes mellitus is one of the important factors predisposing to NB, and diabetic neurogenic bladder (DNB), the most significant complication of the urinary system in diabetic patients, can be as high as 25%-87% (2). The pathogenesis of DNB involves oxidative stress damage, abnormal expression of cell signaling molecules, and impaired neurotransmission pathways in a high-glucose environment (3).…”

Section: Introductionmentioning

confidence: 99%

High glucose-induced imbalance of mitochondria-associated ER membranes function promotes RSC96 cell damage

Housheng Fu,

Jianbing Xu,

Fei Wang

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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Bladder cancer in patients with neurogenic bladder disorder: a comparative study of different etiologies

Cited by 6 publications

References 22 publications

Onkologische Relevanz neurourologischer Erkrankungen

Onkologische Relevanz neurourologischer Erkrankungen

Clinical characteristics and molecular mechanisms underlying bladder cancer in individuals with spinal cord injury: a systematic review

High glucose-induced imbalance of mitochondria-associated ER membranes function promotes RSC96 cell damage

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