Bladder cancer – the neglected tumor: a descriptive analysis of publications referenced in MEDLINE and data from the register clinicaltrials.gov

Kunath, Frank; Krause, Steffen; Wullich, Bernd; Goebell, Peter J.; Engehausen, Dirk G.; Burger, Maximilian; Meerpohl, Joerg J; Keck, Bastian

doi:10.1186/1471-2490-13-56

Cited by 10 publications

(5 citation statements)

References 19 publications

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“…Despite current effective treatments to ensure better results for UCB patients, diagnostic and prognostic exams are still partially accurate and should be complemented with auxiliary tests. Therefore, more clinical research on UCB should be encouraged to allow a significant increase in clinical data, better comprehension of the biology of the disease, and optimization of diagnostic and prognostic tests ( 48 ).…”

Section: Discussionmentioning

confidence: 99%

Impact of reduced levels of APE1 transcripts on the survival of patients with urothelial carcinoma of the bladder

et al. 2015

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Molecular evidence indicates that alterations in genes involved in the maintenance of genome stability may be related to susceptibility to bladder carcinoma. Our goal was to evaluate the prognostic role of base excision repair (BER) genes in a cohort of patients diagnosed with primary urothelial carcinoma of the bladder (UCB). The levels of all APE1, XRCC1 and POLB transcripts were detected by quantitative real-time PCR (qPCR) technique in tumor samples from 52 patients undergoing transurethral resection (TUR) for primary UCB at the Department of Urology, Brazilian National Cancer Institute, Rio de Janeiro. Increased levels of APE1, XRCC1 and POLB transcripts were significantly associated with high-grade tumors when compared to these levels in low-grade tumors (p<0.01) and could be attributed to different mechanisms of transcriptional regulation as a response to tumorigenesis and oxidative stress. By analyzing the collected data in the present study, regardless of pathological grade or stage, univariate analysis revealed that the reduced levels of APE1 transcripts were significantly associated with cancer-specific mortality (p=0.032). Furthermore, the variant genotype (TG/GG) of the APE1 T1349G polymorphism was observed in 75% of a subset of patients who concomitantly experienced reduced levels of the APE1 transcript and death and/or recurrence events. Taken together, our data reinforce the idea that human DNA repair mechanisms must be finely regulated in order to avoid instability leading to tumorigenesis and poor clinical outcomes in UCB patients.

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Section: Discussionmentioning

confidence: 99%

Impact of reduced levels of APE1 transcripts on the survival of patients with urothelial carcinoma of the bladder

et al. 2015

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“…Australia has a similar survival rate, with 1111 deaths from BCa in Australia in 2015 . Despite this, historically, it has been neglected in both health policy agendas and allocation of funding for research . Recently, there has been increasing recognition that BCa is a forgotten cancer, despite it affecting the lives of thousands of patients and having a significant impact on the healthcare system .…”

Section: Introductionmentioning

confidence: 99%

Assessment of the use of the Internet and social media among people with bladder cancer and their carers, and the quality of available patient‐centric online resources: a systematic review

et al. 2019

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ObjectiveTo conduct a systematic synthesis of the literature evaluating the use of the Internet and social media by people with bladder cancer (BCa) and their carers, and to synthesize the evidence on the quality of available online resources for patients with BCa.Methods , written in the English language and meeting the inclusion criteria. Data sources included PubMed, PsycINFO, EMBASE, Web of Science and Scopus. ResultsA total of 15 studies were included in the review. Four studies explored patterns of Internet use among patients with BCa, five studies investigated social media use related to BCa and six studies evaluated the quality of online resources available for patients with BCa. Evidence in all these three dimensions was limited in its ability to establish rigorously if use of the Internet, social media and online resources for BCa is effective in improving the care outcomes for patients with BCa. ConclusionOur review emphasizes the forgotten status of BCa by establishing that, despite its high global incidence, it remains underrepresented in the building of evidence on patient information needs and the possible role of online spaces. Our synthesis establishes that further research is needed to examine the full impact of online information and social media use on the health management of people with BCa.

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“…The interrelation between comorbidity, complication rate, and 90-day mortality underlines the need for a comprehensive geriatric assessment of elderly patients with MIBC in whom RC is indicated [2]. Unfortunately, in many ways, bladder cancer remains a neglected disease [3]. It is easy for a patient to relapse after treatment, and most patients die of tumor metastasis and chemoresistance [4].…”

Section: Introductionmentioning

confidence: 99%

Bladder Tumor Heterogeneity: The Impact on Clinical Treatment

Chen¹,

Qi²,

Cao³

et al. 2015

Urol Int

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Bladder cancer relapse and treatment failure in most patients have often been attributed to chemoresistance in tumor cells and metastasis. Emerging evidence indicates that tumor heterogeneity may play an equally important role and extends to virtually all measurable properties of cancer cells. Although the idea of tumor heterogeneity is not new, little attention has been paid to applying it to understand and control bladder cancer progression. With the development of biotechnology, such as Gene sequencing, recent advances in understanding its generation model, original basis, consequent problems, and derived therapies provide great potential for tumor heterogeneity to be considered a new insight in the treatment of bladder cancers.

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Bladder cancer – the neglected tumor: a descriptive analysis of publications referenced in MEDLINE and data from the register clinicaltrials.gov

Cited by 10 publications

References 19 publications

Impact of reduced levels of APE1 transcripts on the survival of patients with urothelial carcinoma of the bladder

Impact of reduced levels of APE1 transcripts on the survival of patients with urothelial carcinoma of the bladder

Assessment of the use of the Internet and social media among people with bladder cancer and their carers, and the quality of available patient‐centric online resources: a systematic review

Bladder Tumor Heterogeneity: The Impact on Clinical Treatment

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