Bladder cancer: total antioxidant capacity and pharmacotherapy with vitamin-E

Mazdak, Hamid; Ghamari, Zahra Tolou; Gholampour, Mehdi

doi:10.1007/s11255-020-02411-3

Cited by 9 publications

(3 citation statements)

References 39 publications

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“…and Mazdak et al . also found that the urinary and blood total antioxidant status (TAS), showing an ability the plasma to defend itself against free radicals, consisting in their inactivation to substances with a neutral charge, had diminished in the BC objects relative to the controls 38 , 39 . Additionally, our research confirmed an approximately 25% decrease in NEAC depending on the stage of BC progression (TaG1 vs. T1G2, p < 0.05).…”

Section: Discussionmentioning

confidence: 95%

Oxidative stress parameters as biomarkers of bladder cancer development and progression

Wigner

Szymańska

Bijak

et al. 2021

Sci Rep

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The epidemiological studies confirm that the overproduction of free radical is an important factor of cancer induction as well as development, and loss of antioxidant systems efficiency is associated with an increased risk of carcinogenesis. While bladder cancer is the fourth most common type of cancer all over the world, there is little evidence of the advancing changes in oxidative/nitrative stress during the progression of bladder cancer. Our study aimed to investigate the plasma levels of typical markers of oxidative/nitrative stress depending on the clinical classification of bladder cancer differentiation and infiltration degree. We examined 40 patients with newly diagnosed bladder cancer and 20 healthy volunteers as a control group. We analysed the plasma levels of protein carbonyls, thiol groups, 3-nitrotyrosine, lipid peroxidation, as well as non-enzymatic plasma antioxidant capacity using DPPH· and ABTS·+ radicals. We confirmed that all analysed biomarkers are higher in enrolled BC patients than in healthy subjects. Furthermore, our findings demonstrate a positive correlation between the degree of bladder cancer progression and the level of oxidative stress, but no correlation in the case of NT-3. Based on obtained results, we might conclude that during carcinogenesis of the bladder increased oxidative damage of biomolecules is manifested. This indicates the participation of oxidative stress in the development of bladder cancer, and it is important the ensure the proper antioxidant protection.

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Section: Discussionmentioning

confidence: 95%

Oxidative stress parameters as biomarkers of bladder cancer development and progression

Wigner

Szymańska

Bijak

et al. 2021

Sci Rep

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“…In einer kleinen RCT an 46 Patient*innen mit oberflächlichem Blasenkarzinom traten im Vitamin-E-Arm weniger Lokalrezidive auf (19 vs. 36 %). Die mittlere Zeit bis zum Auftreten des Rezidivs unterschied sich zwischen den Gruppen jedoch nicht signifikant 18 . Eine rezente RCT aus England (SELENIB-Trial) hat bei 270 Patient*innen mit nicht muskelinvasiven Blasenkarzinom unter Vitamin-E-Gabe ein signifikant kürzeres Intervall bis zur Rekurrenz gezeigt 19 .…”

Section: Vitamineunclassified

Supplementierung von Vitaminen und Spurenelementen bei urologischen Malignomen

Bauer-Büntzel,

Büntzel

2024

Zeitschrift für Komplementärmedizin

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SummaryDie Einnahme von Vitaminen und Spurenelementen zählt zu den biologischen Verfahren der Komplementärmedizin. Sie wird von Patient*innen zur Prophylaxe und auch zur (Supportiv-)Therapie bei Krebserkrankungen eingesetzt. Die S3-Leitlinie „Komplementärmedizin in der Behandlung onkologischer PatientInnen“ bietet eine Übersicht über die Studienlage und gibt Empfehlungen für oder gegen den Einsatz von Nährstoff-Supplementen. Anhand der Leitlinie wird im Folgenden die Studienlage für ausgewählte Vitamine und Spurenelemente herausgearbeitet. Dieses praktische Werkzeug ermöglicht es Behandelnden, evidenzbasiert zur Nutzung von Supplementen zu beraten und auf potenzielle Fallstricke in der Anwendung hinweisen zu können. Ein besonderer Schwerpunkt liegt hierbei auf urologischen Malignomen.

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“…At the same time, a series of studies have shown that dietary intake of antioxidant vitamins is associated with lower ROS and better-preserved muscle mass [12][13][14]; Additionally, exogenous supplementation of appropriate amounts of vitamins can protect against muscle loss during aging [15,16]. Total antioxidant capacity (TAC) is a term that re ects the antioxidant potential of dietary sources [17,18], which are mainly a combination of various vitamins [19][20][21]. Researchers believe that TAC participates in the progression of several diseases, such as hypertension and cancer [22,23].…”

Section: Introductionmentioning

confidence: 99%

Dietary Total Antioxidant Capacity is Closely Associated with Skeletal Muscle Mass: A Cross-Sectional Study

Fang,

zhang,

Wang

2024

Preprint

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Skeletal muscle is of great importance for human activity and quality of life, as its loss contributes greatly to immobilization, especially for aged individuals. An increased dietary intake of antioxidant vitamins may be beneficial for muscle loss because of aging. However, the quantitative relationship between total antioxidation capacity (TAC) of antioxidant vitamins and muscle mass is undetermined. 4009 participants from the National Health and Nutrition Examination Survey (NHANES) were included. Multivariate linear regression analysis was performed with demographic, lifestyle and dietary intake adjustment factors. The dose saturation effect was also determined by a saturation effect analysis. Subgroup analysis were performed forage and sex. In the fully adjusted model, per unit increase of dietary TAC was associated with an increase of 0.018 g/kg appendicular lean mass (95% CI: 0.007–0.029), 0.014 g/kg trunk lean mass (95% CI: 0.004–0.024) and 0.035 g/kg total lean mass (95% CI: 0.014–0.055). TAC was associated with an decrease of 0.004 kg/kg total percent fat (95% CI: -0.006–-0.002), 0.005 kg/kg trunk percent fat (95% CI: -0.007–-0.002) and 0.003 kg/m2 BMI (95% CI: -0.006–-0.001) at the same time. Subgroup analysis indicated that women and adults <50 years may experience the most significant association between TAC and skeletal muscle mass. We revealed a positive correlation between TAC and lean body mass, a negative association between TAC and body fat and BMI. Saturation values were found among people aged 40–59. Age and sex mediate these associations.

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Bladder cancer: total antioxidant capacity and pharmacotherapy with vitamin-E

Cited by 9 publications

References 39 publications

Oxidative stress parameters as biomarkers of bladder cancer development and progression

Oxidative stress parameters as biomarkers of bladder cancer development and progression

Supplementierung von Vitaminen und Spurenelementen bei urologischen Malignomen

Dietary Total Antioxidant Capacity is Closely Associated with Skeletal Muscle Mass: A Cross-Sectional Study

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