Bladder cancer

Mushtaq, Jameel; Thurairaja, Ramesh; Nair, Rajesh

doi:10.1016/j.mpsur.2019.07.003

Cited by 37 publications

(38 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They may also spread directly to adjacent pelvic structures, including the prostate, urethra, uterus, and vagina. Lymphatic metastasis occurs via the obturator, presacral, iliac and para-aortic lymph nodes, while hematogenous spread usually results in metastases to the liver, lungs, bones, and adrenal glands and is associated with a poor prognosis [4].…”

Section: Etiologymentioning

confidence: 99%

“…Five percent of worldwide bladder cancer cases arise from squamous cells, and these cases are more incident in Africa, likely due to schistosomiasis, a protozoal infection which promotes inflammation [14]. The remaining 5% are composed of rare subtypes such as adenocarcinoma, sarcoma, and metastases to the bladder [4].…”

Section: Etiologymentioning

confidence: 99%

“…The bladder is also lined with smooth muscle that can relax to accommodate greater volumes, as well as contract (under voluntary or reflex control) to expel urine down the urethra and out of the body [3]. The urothelial cells lining the bladder and urinary tract are constantly exposed to environmental, potentially mutagenic agents that are filtered into the urine by the kidneys [4]. Unsurprisingly, 90% of bladder cancer cases, especially those in the developed world, arise from these urothelial cells, mostly in the bladder but on rare occasions in the urinary tract as well.…”

Section: Introductionmentioning

confidence: 99%

“…Although tobacco consumption has fallen over past decades in the US [7], bladder cancer mortality has remained consistent, likely due to a "lag effect" from previous tobacco consumption [8]. In fact, approximately 80% of cases of bladder cancer are diagnosed in adults age 65 or older, reflecting a disease course that requires decades of exposure or develops decades after exposure [4]. Heritable genetic predispositions have also been implicated in approximately 7% of bladder cancer cases [9].…”

Section: Introductionmentioning

confidence: 99%

“…External beam radiation may also be used. For the treatment of metastatic disease (which currently only has a 5% 5-year survival rate), platinum chemotherapy remains the standard, though novel immunotherapies, namely checkpoint inhibitors, are growing in popularity as treatment options in first-line and beyond [4].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Epidemiology of Bladder Cancer

Saginala¹,

et al. 2020

View full text Add to dashboard Cite

Based on the latest GLOBOCAN data, bladder cancer accounts for 3% of global cancer diagnoses and is especially prevalent in the developed world. In the United States, bladder cancer is the sixth most incident neoplasm. A total of 90% of bladder cancer diagnoses are made in those 55 years of age and older, and the disease is four times more common in men than women. While the average 5-year survival in the US is 77%, the 5-year survival for those with metastatic disease is a measly 5%. The strongest risk factor for bladder cancer is tobacco smoking, which accounts for 50–65% of all cases. Occupational or environmental toxins likewise greatly contribute to disease burden (accounting for an estimated 20% of all cases), though the precise proportion can be obscured by the fact bladder cancer develops decades after exposure, even if the exposure only lasted several years. Schistosomiasis infection is the common cause of bladder cancer in regions of Africa and the Middle East and is considered the second most onerous tropical pathogen after malaria. With 81% of cases attributable to known risk factors (and only 7% to heritable mutations), bladder cancer is a prime candidate for prevention strategies. Smoking cessation, workplace safety practices, weight loss, exercise and schistosomiasis prevention (via water disinfection and mass drug administration) have all been shown to significantly decrease the risk of bladder cancer, which poses a growing burden around the world.

show abstract

Section: Etiologymentioning

confidence: 99%

Section: Etiologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Epidemiology of Bladder Cancer

Saginala¹,

et al. 2020

View full text Add to dashboard Cite

show abstract

Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme

da Silva,

Scholl,

de Fraga Dias

et al. 2023

Purinergic Signalling

View full text Add to dashboard Cite

Metabolomic profiling of human bladder tissue extracts

Ossoliński,

Ruman,

Copié

et al. 2024

Metabolomics

View full text Add to dashboard Cite

IntroductionBladder cancer is a common malignancy affecting the urinary tract and effective biomarkers and for which monitoring therapeutic interventions have yet to be identi ed. ObjectivesMajor aim of this work was to perform metabolomic pro ling of human bladder cancer and normal tissue and to evaluate cancer biomarkers Methods This study utilized nuclear magnetic resonance (NMR) and high-resolution nanoparticle-based laser desorption/ionization mass spectrometry (LDI-MS) methods to investigate polar metabolite pro les in tissue samples from 99 bladder cancer patients. ResultsThrough NMR spectroscopy, six tissue metabolites were identi ed and quanti ed as potential indicators of bladder cancer, while LDI-MS allowed detection of 34 compounds which distinguished cancer tissue samples from normal tissue. Thirteen characteristic tissue metabolites were also found to differentiate bladder cancer tumor grades and thirteen metabolites were correlated with tumor stages. Receiver-Operating Characteristics analysis showed high predictive power for all three types of metabolomics data, with area under the curve (AUC) values greater than 0.853. ConclusionTo date, this is the rst study in which human normal tissues adjacent to cancerous tissues are analyzed. These ndings suggest that the metabolite markers identi ed in this study may be useful for the detection and monitoring of bladder cancer stages and grades.

show abstract

Bladder cancer

Cited by 37 publications

References 9 publications

Epidemiology of Bladder Cancer

Epidemiology of Bladder Cancer

Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme

Metabolomic profiling of human bladder tissue extracts

Contact Info

Product

Resources

About