Bladder contractility index in posterior urethral valve: A new marker for early prediction of progression to renal failure

Ansari, M.S.; Nunia, Sandeep; Bansal, Ankur; Singh, Prempal; Sekhon, Virender; Singh, Dharmveer; Soni, Rahul; Yadav, Priyank

doi:10.1016/j.jpurol.2017.09.029

Cited by 14 publications

(12 citation statements)

References 12 publications

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“…They found that bladder contractility index, end filling pressure, and bladder compliance were significantly associated with the study endpoint. Specifically, the ROC cut-off level for bladder contractility index predicting the primary endpoint showed a modest diagnostic performance, with a sensitivity of 78.2% and specificity of 62.5% (44). Thus, the bladder contractility index was adjudged a valuable tool for early detection of PUV patients at risk of progression to stages of CKD.…”

Section: Novel Biomarkersmentioning

confidence: 99%

“…Also, other authors had previously reported a bladder-dysfunction prevalence rate of as high as 75% despite a successful primary valve ablation (43). It is not surprising that a recent study has recommended that the bladder contractility index from a well-conducted urodynamic study could serve as a reliable tool for prognostication in PUV (44). Secondly, VUR is recognized as a significant prognostic factor in children with PUV as its persistence is associated with a poor renal outcome (45).…”

Section: Novel Biomarkers Of Obstructive Nephropathymentioning

confidence: 99%

“…In a recent study, some urodynamic parameters (such as bladder-contractility index, bladder-outlet obstruction index, end-filling pressure, bladder compliance, and bladder-volume efficiency) were correlated with progression to late stages of CKD in PUV patients after valve fulguration (44). The authors applied Cox regression analysis to risk factors predicting the development of late stages of CKD.…”

Section: Novel Biomarkersmentioning

confidence: 99%

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Posterior urethral valve in children: Using novel biomarkers as an early predictive tool for the onset and progression of chronic kidney disease

Uwaezuoke

Odimegwu²,

Mbanefo³

et al. 2022

Front. Urol.

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This narrative review aims to appraise the current evidence on using biomarkers of obstructive nephropathy to predict the onset and progression of chronic kidney disease (CKD) in infants with posterior urethral valves (PUV). PUV is the most frequently reported congenital anomaly of the kidney and urinary tract (CAKUT) associated with bladder outlet obstruction in male children. It contributes significantly to the CKD burden in childhood. Despite different approaches for its postnatal repair, evidence-based data still suggest a high risk of CKD and end-stage kidney disease (ESKD) later in childhood. In obstructive nephropathy, glomerular and tubulointerstitial lesions contribute to renal impairment. Although it may be difficult to predict these adverse renal outcomes in repaired PUV, detecting and monitoring future CKD appears enhanced using the combination of serum creatinine- or cystatin C-based estimated glomerular filtration rate (eGFR) and albuminuria. Given the drawbacks of these conventional biomarkers, there is a paradigm shift to novel biomarkers as tools for the early identification of glomerular and tubulointerstitial lesions seen in obstructive nephropathy. Most novel biomarkers are yet to be fully applied to routine clinical practice globally. Nevertheless, there is substantial evidence showing that they form part of the emerging diagnostics for obstructive nephropathy. From the reviewed studies, urine transforming growth factor-beta 1 (TGF-β1) is the most prominent biomarker among the novel biomarkers of obstructive nephropathy. However, other novel approaches like the machine learning (ML) model (a form of health-related artificial intelligence) and urodynamic parameters like bladder contractility index hold promise for PUV outcomes prediction (PUVOP). Because of the association of urine TGF-β1 with urine angiotensin level (a biomarker of the renin-angiotensin-aldosterone system [RAAS]), early angiotensin-converting enzyme inhibitor (ACEI) therapy in patients with PUV may potentially retard the progression of CKD and improve renal outcomes. Thus, future research directions will be to explore the role of ACEI as a pre-emptive treatment for poor renal outcomes in post valve-ablation patients and to conduct longitudinal studies that would properly demonstrate these biomarkers as predictors of these outcomes.

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Section: Novel Biomarkersmentioning

confidence: 99%

Section: Novel Biomarkers Of Obstructive Nephropathymentioning

confidence: 99%

Section: Novel Biomarkersmentioning

confidence: 99%

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Posterior urethral valve in children: Using novel biomarkers as an early predictive tool for the onset and progression of chronic kidney disease

Uwaezuoke

Odimegwu²,

Mbanefo³

et al. 2022

Front. Urol.

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“…Several theories try to explain the mechanism underlying bladder hypocontractility and myogenic failure, including the hyperactivity of the detrusor muscle, the bladder neck hypertrophy, the co-existent vesicoureteral reflux and the anticholinergic medication. The morphologic changes are represented by the increasing extracellular matrix in the bladder wall, as well as changing the ratio between collagen type III and I [19,20].…”

Section: Urodynamic Studiesmentioning

confidence: 99%

“…In a recent study, Ansari analyzed urodynamic parameters and their correlation with chronic kidney disease, showing a strong association between the bladder contractility index, calculated with the formula BCI= PdetQmax+5Qmax, and the long-term progression towards chronic kidney disease stage III [20].…”

Section: Urodynamic Studiesmentioning

confidence: 99%

Prognostic Biomarkers and Factors in Posterior Urethral Valves

Luchița¹,

Serban²,

Ionescu³

2020

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The bladder contractility and bladder outlet obstruction indices in children. Results of a global Delphi consensus study

Sinha

Hashim

Agrò

et al. 2023

Neurourology and Urodynamics

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Aims: This Delphi study was planned to examine global expert consensus with regard to utility, accuracy, and categorization of Bladder Contractility Index (BCI), Bladder Outlet Obstruction Index (BOOI), and the related evidence. This manuscript deals with children and follows previous manuscripts reporting on adult men and women.Methods: Eighteen experts were invited to answer the two-round survey including three foundation questions and four survey questions. Consensus was defined as ≥75% agreement. The ordinal scale (0-10) in Round 1 was classified into "strongly agree," "agree," "neutral," "disagree," and "strongly disagree" for the final round. A systematic search for evidence was conducted for therapeutic studies that have examined outcome stratified by the indices in children.Results: Eleven experts participated in the survey with 100% completion.Consensus was not noted with regard to any of the questions. There was a general trend toward disagreement with the utility of the BCI and BOOI in children. Systematic search yielded one publication pertaining the value of the indices in predicting long-term outcome in boys treated for posterior urethral valves. Conclusions: This global Delphi survey of experts showed a general disinclination to use numerical indices for bladder contractility and bladder outflow obstruction in children. There is very little data on the use of the BCI and BOOI indices in children. The establishment of urodynamic indices in children might help refine the treatment of functional urological disorders in children.

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Bladder contractility index in posterior urethral valve: A new marker for early prediction of progression to renal failure

Cited by 14 publications

References 12 publications

Posterior urethral valve in children: Using novel biomarkers as an early predictive tool for the onset and progression of chronic kidney disease

Posterior urethral valve in children: Using novel biomarkers as an early predictive tool for the onset and progression of chronic kidney disease

Prognostic Biomarkers and Factors in Posterior Urethral Valves

The bladder contractility and bladder outlet obstruction indices in children. Results of a global Delphi consensus study

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