Bladder Endometriosis: A Systematic Review of Pathogenesis, Diagnosis, Treatment, Impact on Fertility, and Risk of Malignant Transformation

Maggiore, Umberto Leone Roberti; Ferrero, Simone; Candiani, Massimo; Somigliana, Edgardo; Viganò, Paola; Vercellini, Paolo

doi:10.1016/j.eururo.2016.12.015

Cited by 136 publications

(114 citation statements)

References 156 publications

(225 reference statements)

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“…the urinary bladder and/or ureters, is affected, often causing ureteric obstruction and secondary hydronephrosis . Within this group, bladder endometriosis (BE) appears to occur more frequently than ureteral endometriosis (UE) or hydronephrosis . Symptoms related to BE often include urinary frequency, urgency, bladder pain, dysuria and hematuria, but these are not necessarily present in all patients with bladder disease .…”

Section: Introductionmentioning

confidence: 99%

“…Within this group, bladder endometriosis (BE) appears to occur more frequently than ureteral endometriosis (UE) or hydronephrosis . Symptoms related to BE often include urinary frequency, urgency, bladder pain, dysuria and hematuria, but these are not necessarily present in all patients with bladder disease . In addition, secondary hydronephrosis does not occur abruptly but as a slowly progressing obstructive mechanism thereby often lacking symptoms such as flank pain .…”

Section: Introductionmentioning

confidence: 99%

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Outcome of sonography‐based minimally invasive surgery for deep infiltrating endometriosis of the ureter and urinary bladder – a retrospective cohort study

Hudelist

Tammaa

Aas-Eng

et al. 2017

Acta Obstet Gynecol Scand

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Outcome of sonography‐based minimally invasive surgery for deep infiltrating endometriosis of the ureter and urinary bladder – a retrospective cohort study

Hudelist

Tammaa

Aas-Eng

et al. 2017

Acta Obstet Gynecol Scand

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“…Однако существуют данные, противоречащие этим гипоте-зам: 1) гистологические материалы, подтверждающие нали-чие эмбриональных зачатков в области маточно-пузырного пространства, никогда не были предоставлены; 2) доказа-но, что гладкомышечные клетки присутствуют во всех типах эндометриоидных гетеротопий [4]; 3) в большинстве опуб-ликованных исследований не обнаружено сочетание узлово-го аденомиоза с ЭМП [5].…”

Section: Discussionunclassified

“…При контрольной МРТ органов мало-го таза через 6 месяцев отмечена положительная динамика в виде уменьшения размеров эндометриоидных изменений в стенке мочевого пузыря и в перивезикальной клетчатке, кистозного образования правого яичника с 25 мм до 8 мм (рис. 4,5). В настоящее время на фоне применения диено-геста в течение 12 месяцев у пациентки отсутствуют жалобы и признаки рецидива заболевания.…”

Section: примечание белок P53 -транскрипционный фактор регулирующийunclassified

“…По дан-ным патоморфологического исследования, три опухоли были представлены эндометриоидными, четыре -светлоклеточ-ными карциномами и одна -эндометриоидной стромаль-ной саркомой [5].…”

Section: на стыке дисциплинunclassified

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Atypical Endometriosis of the Urinary Bladder: Review of the Literature and a Clinical Case

Байрамова¹,

Protasova²,

Bairamov³

et al. 2018

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НА СТЫКЕ ДИСЦИПЛИНObjective of the Paper: To describe a clinical case of atypical endometriosis (AEM) of the urinary bladder. Key Points: The paper describes a first-hand observation of a clinical case of AEM of the urinary bladder in a woman of reproductive age. The authors propose a panel of immunohistochemical markers that will improve the diagnosis of AEM, viewed as a morphological precancerous condition. They also discuss the latest data from the literature on the specific aspects of the pathogenesis, diagnosis, clinical course, treatment methods, and risk factors for malignant transformation of this rare condition. Conclusion: Challenges in the differential diagnosis and histological verification of AEM of the urinary bladder make it necessary to evaluate the immunohistochemical expression of the BAF250a (ARID1a), β-catenin, PTEN, Ki-67, and p53 markers. Curative resection of areas of endometriosis combined with long-term adjuvant treatment with dienogest is the most effective therapeutic approach. Keywords: atypical endometriosis, endometriosis of the urinary bladder, dienogest, urinary bladder resection, conserving therapy, BAF250a (ARID1a), PTEN, β-catenin. «АВА-ПЕТЕР». 199034, г. Санкт-Петербург, Университетская наб., д. 7-9. E-mail: protasova1966@yandex.ru (Окончание на с. 62.) Атипический эндометриоз мочевого пузыряЦель статьи: представить клиническое наблюдение атипического эндометриоза мочевого пузыря (ЭМП). Основные положения. В статье описано собственное наблюдение атипической формы ЭМП у женщины репродуктивного возраста. Предложена панель иммуногистохимических маркеров, которая позволит улучшить диагностический поиск атипического эндометриоза, рассматриваемого как морфологическая форма предрака. Освещены также особенности патогенеза, диагностики, клинического течения, методов лечения и риска злокачественной трансформации этого редкого заболевания, рассматриваемые в современной литературе. Заключение. Сложность дифференциальной диагностики и гистологической верификации атипической формы ЭМП диктует необходи-мость проведения иммуногистохимического исследования с оценкой экспрессии маркеров BAF250a (ARID1a), β-катенина, PTEN, индекса Ki-67, p53. Радикальное удаление эндометриоидных очагов в комбинации с длительной адъювантной терапией диеногестом является наиболее эффективным методом лечения. Ключевые слова: атипический эндометриоз, эндометриоз мочевого пузыря, диеногест, резекция мочевого пузыря, органосохраняющее лечение, BAF250a (ARID1a), PTEN, β-катенин.

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Magnetic resonance imaging versus transvaginal ultrasound for complete survey of the pelvic compartments among patients with deep infiltrating endometriosis

Gutiérrez

Spagnolo

Hidalgo

et al. 2019

Intl J Gynecology & Obste

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Objective: To compare the performance of magnetic resonance imaging (MRI) and transvaginal ultrasound (TVU) in detecting deep infiltrating endometriosis (DIE), using Enzian classification. Secondarily, to evaluate the influence of nodule size on the accuracy of MRI and TVU. Methods: A retrospective study was carried out at "La Paz" University Hospital, Madrid, Spain, between April 2012 and December 2014. Inclusion criteria were suspicion of DIE at gynecologic examination, indication to undergo TVU, MRI and surgery. Exclusion criteria were previous hysterectomy, bowel resection, or urinary tract surgery. The diagnosis of DIE using MRI or TVU was considered positive when it correlated with histology.Sensitivity, specificity, accuracy, and mean size of the nodule were calculated. Results:In the present study involving 48 women, TVU demonstrated greater accuracy than MRI for recto-vaginal (77% vs 69%) and vaginal (94% vs 89%) endometriosis. MRI showed greater accuracy (96%) than TVU (92%) for bladder endometriosis. The size of the nodule did not have a significantly different effect on the accuracy of TVU compared with MRI. Conclusion:In the present study, TVU provided a more accurate localization of vaginal and recto-vaginal endometriosis as compared with MRI; however, MRI should be recommended if a suspicion of bladder endometriosis exists. The nodule size did not seem to influence the accuracy of the two techniques.

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Bladder Endometriosis: A Systematic Review of Pathogenesis, Diagnosis, Treatment, Impact on Fertility, and Risk of Malignant Transformation

Abstract: In this article we review available knowledge on bladder endometriosis. The review provides a useful tool to guide physicians in the management of this complex condition.

Cited by 136 publications

References 156 publications

Outcome of sonography‐based minimally invasive surgery for deep infiltrating endometriosis of the ureter and urinary bladder – a retrospective cohort study

Outcome of sonography‐based minimally invasive surgery for deep infiltrating endometriosis of the ureter and urinary bladder – a retrospective cohort study

Atypical Endometriosis of the Urinary Bladder: Review of the Literature and a Clinical Case

Magnetic resonance imaging versus transvaginal ultrasound for complete survey of the pelvic compartments among patients with deep infiltrating endometriosis

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