Bladder exstrophy and male fertility: pregnancies after ICSI with ejaculated or epididymal sperm

D’Hauwers, Kathleen; Feitz, W. F. J.; Kremer, J.A.M.

doi:10.1016/j.fertnstert.2007.03.005

Cited by 13 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding, combined with an estimated recurrence risk of 0.3 to 0.8 in children born to patients with BEEC (Ludwig et al, 2005), might influence the counseling of adult patients for assisted reproduction (AR). However, as reviewed in two recent reports (D'Hauwers et al, 2008; Gambhir et al, 2008b), successful reproductive outcomes were achieved in at least nine male patients with BEEC using AR, including IVF and intracytoplasmic sperm injection (ICSI).…”

Section: Discussionmentioning

confidence: 99%

Bladder exstrophy‐epispadias complex

Ludwig

Ching

Reutter

et al. 2009

Birth Defects Research

View full text Add to dashboard Cite

The bladder exstrophy-epispadias complex (BEEC) represents an anterior midline defect with variable expression comprising a spectrum of anomalies involving the abdominal wall, pelvis, urinary tract, genitalia, and occasionally the spine and anus. The vast majority of BEEC cases are classified as non-syndromic and the etiology of this malformation is still unknown. This review presents the current state of knowledge on this multifactorial disorder, including historical retrospect, phenotypic and anatomical characterization, epidemiology, proposed developmental mechanisms, existing animal models, and implicated genetic and environmental components. These published lines of evidence argue strongly that BEEC occurs as a result of strong genetic predisposition that is yet to be deciphered.

show abstract

Section: Discussionmentioning

confidence: 99%

Bladder exstrophy‐epispadias complex

Ludwig

Ching

Reutter

et al. 2009

Birth Defects Research

View full text Add to dashboard Cite

show abstract

“…ICSI has been used to achieve pregnancies in women with male partners with known genetic defects (for example, Klinefelter's syndrome 133,134 , structural chromosome defects including Y chromosome microdeletions and translocations 135,136 , isolated gene defects 137 , globozoospermia (round-headed sperm) 138 , Huntington's syndrome and other triplet repeat diseases 139,140 , Charcot-Marie-Tooth disorder 141–143 , bladder exstrophy 144–146 , CBAVD 131,147 , congenital unilateral absence of the vas deferens 148 , immotile cilia and Kartagener's syndrome 149–152 , cryptorchidism 153 and familial adenomatous polyposis coli 154 ). However, questions about the safety of ART persist 30 years after the first IVF-mediated birth and 16 years after the start of ICSI.…”

Section: Diagnosis and Treatmentmentioning

confidence: 99%

The biology of infertility: research advances and clinical challenges

Matzuk

Lamb

2008

Nat Med

841

675

View full text Add to dashboard Cite

Reproduction is required for the survival of all mammalian species, and thousands of essential ‘sex’ genes are conserved through evolution. Basic research helps to define these genes and the mechanisms responsible for the development, function and regulation of the male and female reproductive systems. However, many infertile couples continue to be labeled with the diagnosis of idiopathic infertility or given descriptive diagnoses that do not provide a cause for their defect. For other individuals with a known etiology, effective cures are lacking, although their infertility is often bypassed with assisted reproductive technologies (ART), some accompanied by safety or ethical concerns. Certainly, progress in the field of reproduction has been realized in the twenty-first century with advances in the understanding of the regulation of fertility, with the production of over 400 mutant mouse models with a reproductive phenotype and with the promise of regenerative gonadal stem cells. Indeed, the past six years have witnessed a virtual explosion in the identification of gene mutations or polymorphisms that cause or are linked to human infertility. Translation of these findings to the clinic remains slow, however, as do new methods to diagnose and treat infertile couples. Additionally, new approaches to contraception remain elusive. Nevertheless, the basic and clinical advances in the understanding of the molecular controls of reproduction are impressive and will ultimately improve patient care.

show abstract

“…D'Hauwers used GIFT or ICSI in 21 men with exstrophy struggling with infertility and obtained successful pregnancies in all patients. 60…”

Section: Orgasm Ejaculation and Fertilitymentioning

confidence: 99%