Bladder Exstrophy Complicated by Adenocarcinoma

Surgical Management of Ectopia Vesicae- A Tertiary Care Centre- Our Experience With Three Cases

“…13 Of the remaining, about 20% each occur after 60 years and before 40 years. The most common tumour is adenocarcinoma (95%) 14,15 and 3% to 5% are squamous cell carcinomas. 12,16 Squamous metaplasia has been found in 80% of cases.…”

Carcinoma epidermoide en extrofia de vejiga

“…Estos autores concluyen que el riesgo de carcinoma en la vejiga de estos pacientes es 694 veces superior al de la población de la misma edad con vejigas normales 3 . La coexistencia de epitelio de transición asociado a metaplasia escamosa y glandular (que ocurre con frecuencia en mucosas crónicamente irritadas e inflamadas) o tejido epitelial intestinal ectópicos son las etiología de presunción 1,2,5 .…”

Urinary System

“…The urachal adenocarcinomas are generally intramural in location with a normal urothelial surface. Although surgical closure of the exstrophic bladder is usually performed in infancy, these patients remain at greater risk for development of adenocarcinoma later in life; more than 80 cases have been reported since 1895 (Witters and Baert-Van Damme 1987). Urachal remnants have not been described in the bladder of adult rats; however, Schubert et al (1982) reported a 32% incidence in an unselected series of 122 adult human autopsies.…”