Bladder function in 17β-estradiol-induced nonbacterial prostatitis model in Wister rat

Matsumoto, Seiji; Kawai, Yuko; Oka, Michiko; Oyama, Tatsuya; Hashizume, Kazumi; Wada, Naoki; Hori, Junichi; Tamaki, Gaku; Kita, Masafumi; Iwata, Tatsuya; Κakizaki, Hidehiro

doi:10.1007/s11255-013-0442-y

Cited by 6 publications

(4 citation statements)

References 16 publications

(15 reference statements)

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“…We did not observe any changes in voiding behavior in either model. The finding that HCP did not cause a significant change in either of these parameters is consistent with previous reports . Although we do not know the precise reason why prostatic inflammation did not result in abnormal bladder function in these two models, it is likely due to a relatively low degree of severity of the prostatic inflammation, because prostatic inflammation induced by the direct injection of irritants such as carrageenan and formalin into the prostate leads to overactive bladder, as detected by cystometry .…”

Section: Discussionsupporting

confidence: 91%

“…The finding that HCP did not cause a significant change in either of these parameters is consistent with previous reports. 20 Although we do not know the precise reason why prostatic inflammation did not result in abnormal bladder function in these two models, it is likely due to a relatively low degree of severity of the prostatic inflammation, because prostatic inflammation induced by the direct injection of irritants such as carrageenan and formalin into the prostate leads to overactive bladder, as detected by cystometry. 7,8 In the prostatitis model induced by injection of irritants into the dorsal lobe of the prostate, inflammation in the prostate increases macrophage infiltration and the expression of T cell markers of the bladder, and prostate-to-bladder afferent crosssensitization is a potential mechanism by which prostatitis could result in bladder overactivity.…”

Section: Discussionmentioning

confidence: 83%

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Voiding behavior and chronic pelvic pain in two types of rat nonbacterial prostatitis models: Attenuation of chronic pelvic pain by repeated administration of tadalafil

et al. 2018

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Background Experimental autoimmune prostatitis (EAP) and prostatitis induced by 17β‐estradiol treatment combined with castration (hormone/castration‐induced prostatitis; HCP) are the most commonly used rodent models of nonbacterial prostatitis. We studied the effect of the phosphodiesterase 5 inhibitor tadalafil on chronic pelvic pain in two such models in rats. Methods EAP was induced by intradermal injection of rat prostate antigen and complete Freund's adjuvant on Days 0 and 28. HCP was induced by castration followed by daily subcutaneous injection of 17β‐estradiol for 30 days. On Day 42 after antigen injection in the EAP model and Day 30 after castration in the HCP model, we investigated voiding behavior, pelvic pain (measured by applying von Frey filaments to the lower abdomen), and inflammatory changes, including changes in histopathology and IL‐1β, CCL2, and CCL3 mRNA levels. We investigated the effect of repeated administration of tadalafil on chronic pelvic pain in both models. Results In the EAP model, we observed inflammation in the ventral prostate, while in the HCP model, we observed inflammation in the lateral lobe of the prostate. Neither model showed any change in voiding behavior. As well as in the EAP model, in which chronic pelvic pain was observed, we found for the first time that HCP led to a significant increase in chronic pelvic pain. Repeated treatment with tadalafil attenuated the chronic pelvic pain in both models. Conclusions Chronic pelvic pain was induced in both EAP and HCP models. Tadalafil significantly attenuated the chronic pelvic pain in both models.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 83%

Voiding behavior and chronic pelvic pain in two types of rat nonbacterial prostatitis models: Attenuation of chronic pelvic pain by repeated administration of tadalafil

et al. 2018

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“…Micturition behavior was studied at 14 days after BOO surgery as previously described . Each rat was placed in an individual metabolic cage with a 12 hr light/dark cycle for three consecutive days for acclimation.…”

Section: Methodsmentioning

confidence: 99%

Effects of the phosphodiesterase 5 inhibitor Tadalafil on bladder function in a rat model of partial bladder outlet obstruction

Kawai

Oka

Yoshinaga

et al. 2015

Neurourology and Urodynamics

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“…7,8 Omegazone, a laser blood flowmeter, can be used to measure the change of blood flow induced by chemical intervention in urinary bladder. [32][33][34][35][36] In this study, we observed the accelerating effect of CRT, and quantitative evaluation should also be made using a cell counter in further steps. Despite these limitations, our findings show that CRT may attenuate damage of the urinary bladder and can be considered a prospective treatment option for OAB patients.…”

Section: Discussionmentioning

confidence: 82%

Therapeutic effects of Choreito, a traditional Japanese (Kampo) medicine, on detrusor overactivity induced by acetic acid in rats

Ueno

Minagawa

Saito

et al. 2020

LUTS

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Choreito (CRT), a traditional Japanese (Kampo) medicine, is widely used for the treatment of overactive bladder (OAB) and other lower urinary tract symptoms in Japan. This study aimed to identify the effects and therapeutic mechanism of CRT on the improvement of detrusor overactivity (DO) using an experimental rat model. Forty‐five female Sprague‐Dawley rats were equally divided into three groups: intravesical saline instillation with normal food (normal group), intravesical acetic acid (AA) instillation with normal food (AA group), and intravesical AA instillation with CRT (AA with CRT group). To induce a decrease in bladder capacity, instillation of 0.2% AA was used based on prior studies. Cystometric investigation was employed to clarify the effects of AA and CRT. Microcirculation was performed using a laser blood flowmeter, and the localization of hypoxia‐inducible factor 1α (HIF1α) was assessed by immunohistochemistry. The bladder capacities of the normal, AA, and AA with CRT groups were 1.2 ± 0.3 mL, 0.4 ± 0.1 mL, and 0.8 ± 0.1 mL, respectively. CRT significantly attenuated AA irritation of the urinary bladder and exerted protective effects on basal pressure, micturition pressure, micturition interval, and micturition volume. Furthermore, CRT could prevent the excess blood flow and edematous change under the urothelium induced by intravesical AA instillation. No obvious changes in immunohistochemical HIF1α staining were observed among the groups. CRT attenuated DO induced by intravesical AA instillation in a rat experimental model. CRT might impart therapeutic effects on OAB via the mitigation of urothelial damage and regulation of excess blood flow.

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Bladder function in 17β-estradiol-induced nonbacterial prostatitis model in Wister rat

Cited by 6 publications

References 16 publications

Voiding behavior and chronic pelvic pain in two types of rat nonbacterial prostatitis models: Attenuation of chronic pelvic pain by repeated administration of tadalafil

Voiding behavior and chronic pelvic pain in two types of rat nonbacterial prostatitis models: Attenuation of chronic pelvic pain by repeated administration of tadalafil

Effects of the phosphodiesterase 5 inhibitor Tadalafil on bladder function in a rat model of partial bladder outlet obstruction

Therapeutic effects of Choreito, a traditional Japanese (Kampo) medicine, on detrusor overactivity induced by acetic acid in rats

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