Bladder metastasis of gastric signet-ring cell carcinoma

Kazaz, İlke Onur; Arslan, Ayhan; Çolak, Fatih; Kazaz, Seher Nazlı; Munğan, Sevdegül; Karagüzel, Ersagun

doi:10.1016/j.eucr.2018.10.013

Cited by 4 publications

(8 citation statements)

References 4 publications

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“…Almost all patients with gross hematuria show a protuberant mass during the imaging scans. In patients with lower urinary tract symptoms as the first symptom, the imaging findings are often diffuse wall thickening ( 12 – 23 , 38 ). In our case, the pelvic CT scan showed the manifestation of the diffuse thickening of the bladder wall for nine months before the diagnosis of SRCC.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Metastatic Signet-Ring-Cell Carcinoma of the Bladder From Breast Invasive Lobular Carcinoma Detected by Computed Tomography

et al. 2022

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Secondary bladder tumors are relatively rare among all bladder tumors, while bladder metastases from breast cancer have been rarely reported. Furthermore, signet-ring differentiation may appear in the metastases from a breast invasive lobular carcinoma regardless of whether the primary breast tumor had signet-ring cells, which may cause diagnostic uncertainty. We report a case of a 55-year-old female patient with diffuse bladder thickening as the chief complaint and no specific clinical manifestations. While the cystoscopy showed multiple scattered red protuberances, the biopsy suggested signet-ring-cell carcinoma. The gastroscopy results suggested poorly differentiated adenocarcinoma with signet-ring cells. Considering the patient’s history of invasive lobular carcinoma of the breast, chronic myeloid leukemia, and metastatic endometrial carcinoma from the breast, we performed an immunohistochemical analysis and the results indicated that signet-ring-cell carcinomas of the stomach and bladder originated from the invasive lobular carcinoma of the breast. We performed positron emission tomography/computed tomography and the results showed that there were multiple bone metastases already present. This was the first English case report of invasive lobular carcinoma of the breast metastasizing to the uterus, stomach, bladder, and bones with multiple signet-ring-cell variations. This study shares our reasons for misdiagnosing and opinions on diagnosing and treating for this kind of cases.

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Section: Discussionmentioning

confidence: 99%

Case Report: Metastatic Signet-Ring-Cell Carcinoma of the Bladder From Breast Invasive Lobular Carcinoma Detected by Computed Tomography

et al. 2022

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“…Primary SRCC of the bladder is extremely uncommon, with an estimated prevalence of 0.24% of all primary bladder cancer (11,12). Metastatic SRCC of the bladder is even rarer (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). We searched PubMed, MEDLINE, Embase, and Google Scholar using the key words such as "gastric or stomach"; "signet-ring-cell carcinoma"; "breast or mammary"; "bladder" and "metastasis."…”

Section: Discussionmentioning

confidence: 99%

“…Almost all the patients with gross hematuria showed a protuberant mass in imaging. While in patients with lower urinary tract symptoms (LUTS) as the rst symptom, the imaging ndings are often diffuse wall thickening (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)36). In our case, the pelvic CT had the manifestation of diffuse thickening of the bladder wall for 9 months before the diagnosis of SRCC.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Signet-Ring-Cell Carcinoma of Bladder From Breast Invasive Lobular Carcinoma Found By CT: A Case Report And Literature Review

Jin

Tang

Chen

et al. 2021

Preprint

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Background: Secondary bladder tumors are relatively rare in all bladder tumors, while bladder metastases from breast cancer were rarely reported. And interestingly, signet-ring differentiation may appear in metastases from a breast invasive lobular carcinoma regardless of whether or not the primary breast tumor had signet-ring cells, which may cause diagnostic uncertainty.Case presentation: We report a case of a 55-year-old female patient with diffuse bladder thickening as the chief complaint. There was no special clinical manifestation, while cystoscopy showed multiple scattered red protuberances and the biopsy suggested signet-ring-cell carcinoma. Result of gastroscopy suggested poorly differentiated adenocarcinoma with signed-ring cells. Considering the patient's previous history of invasive lobular carcinoma of the breast, chronic myeloid leukemia and metastatic endometrial carcinoma from the breast, we performed the immunohistochemistry and the results indicated that signet-ring-cell carcinomas of the stomach and bladder originated from the breast invasive lobular carcinoma. we performed Positron Emission Tomography/Computed Tomography (PET/CT) and the results showed that there were multiple bone metastases already.Conclusion: This is the first English case report of invasive lobular carcinoma of breast metastasizing to uterus, stomach, bladder and bones with multiple signet-ring-cell variations. We also focus on the Computed Tomography (CT), immunohistochemistry (IHC) and cystoscopy findings and share the clinical diagnosis ideas summarized by this case.

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“… 6 Gastric SRC is also associated with aggressive tumor behavior and early metastasis, posing a major public health problem. 7 …”

Section: Introductionmentioning

confidence: 99%

“…6 Gastric SRC is also associated with aggressive tumor behavior and early metastasis, posing a major public health problem. 7 With respect to the treatment of GC, surgery remains the mainstay for localized GC. 8 However, the survival still remains poor for surgery alone, the 5-year survival rate was only 20%-50%, leading to the efforts to improve the prognosis of these patients with adjuvant approaches.…”

Section: Introductionmentioning

confidence: 99%

Preoperative Radiotherapy Is Associated With Significant Survival Benefits for Patients With Gastric Signet Ring Cell Carcinoma: A SEER-Based Approach

Gong

Chu

et al. 2020

Technol Cancer Res Treat

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Objective: To explore the clinical and pathological features of gastric signet ring cell carcinoma, and evaluate the survival impact of preoperative radiotherapy on these patients. Methods: The Surveillance, Epidemiology, and End Results database was used to extract eligible patients from 2004 to 2015. The patients were divided into those with and without preoperative radiotherapy. The categorical variables were described by chi-square tests. The patients’ survival was compared between the 2 groups by Kaplan-Meier method with log-rank tests. Cox proportional hazard model was adopted to identify prognostic factors of cancer-specific survival. Results: Totally 4771 patients were recruited, of whom 218(4.6%) patients received preoperative radiotherapy, while 4553(95.4%) patients didn’t receive this treatment. Survival analysis of the entire cohort demonstrated that preoperative radiotherapy improved both cancer-specific survival and overall survival (p < 0.001) of the patients. Cox proportional hazard models identified age >60, tumor size >50 mm, TNM stage II-IV as independent risk factors for poor prognosis (HR > 1, p < 0.05). Notably, preoperative radiotherapy was identified as an independent protective factor for favorable prognosis (HR < 1, p < 0.05). Subgroup survival analysis showed that preoperative radiotherapy exerted significant survival benefits for the stages III and IV patients. Conclusions: In this population-based study, preoperative radiotherapy is associated with significant survival benefits for the patients with advanced gastric signet ring cell carcinoma. Hence preoperative radiotherapy is feasible for these patients.

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Bladder metastasis of gastric signet-ring cell carcinoma

Cited by 4 publications

References 4 publications

Case Report: Metastatic Signet-Ring-Cell Carcinoma of the Bladder From Breast Invasive Lobular Carcinoma Detected by Computed Tomography

Case Report: Metastatic Signet-Ring-Cell Carcinoma of the Bladder From Breast Invasive Lobular Carcinoma Detected by Computed Tomography

Metastatic Signet-Ring-Cell Carcinoma of Bladder From Breast Invasive Lobular Carcinoma Found By CT: A Case Report And Literature Review

Preoperative Radiotherapy Is Associated With Significant Survival Benefits for Patients With Gastric Signet Ring Cell Carcinoma: A SEER-Based Approach

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