Bladder Neck Urothelial Carcinoma

Abstract

To evaluate the clinicopathology of carcinomas originating in the urinary bladder neck, 316 cystectomies for urinary bladder carcinoma performed between January 1, 2008, and December 31, 2013, were analyzed. Clinicopathological parameters were compared between bladder neck carcinomas (BNCs) and non-BNCs. Among the 316 cystectomies were 19 BNCs and 297 non-BNCs. BNCs accounted for 19/316 (6%) of all the cases, with a male-to-female ratio 18:1. Bladder neck location was significantly associated with advanced tumor stage. Ninety percent and 58% BNCs presented at stage ≥T2 and ≥T3, respectively, versus 62% and 38% non-BNCs at ≥T2 and ≥T3, respectively. Significantly higher percentage of lymphovascular invasion and lymph node metastasis were also seen in BNCs (68% and 47%, respectively) than in non-BNCs (29% and 17%, respectively). In conclusion, BNCs present with a significantly higher frequency of muscle invasion and advanced tumor stage, lymphovascular invasion, as well as local and distant metastasis at diagnosis compared with the non-BNCs group. Recognition of these unique clinicopathologic features with early detection and possibly more aggressive management of BNC can potentially have a significant impact on the patient's outcome.

The dog as an animal model for bladder and urethral urothelial carcinoma: Comparative epidemiology and histology

“…UC affects most commonly the urinary bladder in both people and dogs and represents the most common (over 90%) type of bladder cancer in both species. The lateral and posterior wall are the most common sites of UC in people ( 29 – 31 ), whereas dogs in our and previous studies tend to have UC within the neck and trigone area ( 6 , 32 ). Reasons for the difference in preferred bladder subsites of UC between men and dogs are not known, but they may be due to the different orientation of the bladder within the body, leading to different intravesical urine flow.…”

“…Reasons for the difference in preferred bladder subsites of UC between men and dogs are not known, but they may be due to the different orientation of the bladder within the body, leading to different intravesical urine flow. The prognostic significance of the different tumor bladder subsites is reported with some conflicting results, but involvement of neck or trigone appears to be associated with higher tumor stage and worse prognosis in people ( 29 , 31 ). This could potentially explain the higher UC tumor stages in dogs compared to men.…”

Multiparametric Magnetic Resonance Imaging for Bladder Cancer: Development of VI-RADS (Vesical Imaging-Reporting And Data System)

“…About one-third of new tumors arise from the trigone, bladder neck, and ureteral orifice regions, and a slightly greater number from the lateral walls [31]. Bladder neck cancers have a significantly higher frequency of muscle invasion [52]. The presence of multiple tumors should be recorded, together with details of the greatest disease burden (largest or highest number) and the tumor with radiological appearance of most advanced stage.…”

Neoplasias de la vía urinaria baja: evaluación imagenológica

“…Esto es en especial relevante cuando se considera que las tasas de invasión muscular difieren según la ubicación del tumor. Los cánceres de cuello vesical tienen una frecuencia significativamente mayor de invasión muscular 32 , mientras que, según los informes, el cáncer de la cúpula de la vejiga Figura 6. Capas de la vejiga en resonancia magnética.…”