Bladder tissue engineering: A literature review

O, Lam Van Ba; Aharony, Shachar; Loutochin, Oleg; Corcos, Jacques

doi:10.1016/j.addr.2014.11.013

Cited by 45 publications

(32 citation statements)

References 75 publications

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“…Significant advances have been made in field of bladder repair using autologous patient cells to seed bladder scaffolds (Atala et al, 2006). However, efforts to innervate bladder scaffolds have not been successful (Lam Van Ba et al, 2015; Oberpenning et al, 1999). Thus, detailed understanding of the normal events that occur in development of LUT innervation may lead to strategies for regeneration of damaged or diseased neural inputs in the bladder.…”

Section: Introductionmentioning

confidence: 99%

Migration pathways of sacral neural crest during development of lower urogenital tract innervation

Wiese

Deal

Ireland

et al. 2017

Developmental Biology

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The migration and fate of cranial and vagal neural crest-derived progenitor cells (NCPCs) have been extensively studied; however, much less is known about sacral NCPCs particularly in regard to their distribution in the urogenital system. To construct a spatiotemporal map of NCPC migration pathways into the developing lower urinary tract, we utilized the Sox10-H2BVenus transgene to visualize NCPCs expressing Sox10. Our aim was to define the relationship of Sox10-expressing NCPCs relative to bladder innervation, smooth muscle differentiation, and vascularization through fetal development into adulthood. Sacral NCPC migration is a highly regimented, specifically timed process, with several potential regulatory mileposts. Neuronal differentiation occurs concomitantly with sacral NCPC migration, and neuronal cell bodies are present even before the pelvic ganglia coalesce. Sacral NCPCs reside within the pelvic ganglia anlagen through 13.5 days post coitum (dpc), after which they begin streaming into the bladder body in progressive waves. Smooth muscle differentiation and vascularization of the bladder initiate prior to innervation and appear to be independent processes. In adult bladder, the majority of Sox10+ cells express the glial marker S100β, consistent with Sox10 being a glial marker in other tissues. However, rare Sox10+ NCPCs are seen in close proximity to blood vessels and not all are S100β+, suggesting either glial heterogeneity or a potential nonglial role for Sox10+ cells along vasculature. Taken together, the developmental atlas of Sox10+ NCPC migration and distribution profile of these cells in adult bladder provided here will serve as a roadmap for future investigation in mouse models of lower urinary tract dysfunction.

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Section: Introductionmentioning

confidence: 99%

Migration pathways of sacral neural crest during development of lower urogenital tract innervation

Wiese

Deal

Ireland

et al. 2017

Developmental Biology

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“…Of these, seeded or non-seeded intestine is regarded as the gold standard, although it has been associated with such complications as metabolic acidosis, recurrent infections, calculi, and the risk of cancer [79,80]. The natural function and structure of the bladder has been a great obstacle to finding an appropriate substitute.…”

Section: Bladder Surgeriesmentioning

confidence: 99%

Pericardium in Reconstructive Urologic Surgeries: A Systematic Review and Meta-Analysis

Hosseini

et al. 2018

Urol Int

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Introduction: The use of pericardium has been expanded into different surgical modalities; however, there are scarce data regarding the feasibility of the pericardium in reconstructive urologic surgeries. We systematically reviewed the literature on the effectiveness of the pericardial tissue for reconstructive urologic surgeries. Materials and Methods: PubMed and Scopus were searched online for evidence on the use of the pericardium in urologic surgeries. Through the methodology recommended by the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines, 38 of 4,071 studies were identified. Results: A total of 715 patients and 139 animals underwent reconstructive urologic surgeries using the pericardium. Bladder, urethral, and renal reconstructions were successful in 100% of the human cases. The rates of dissatisfaction, glans hypoesthesia, and penile shortening were comparable between the pericardial graft surgeries and the other operations during penile straightening, but there was a trend among the patients with pericardial grafts toward having a more penile curvature at follow-up (risk ratio [RR] 2.03, 95% CI 0.90–4.61, p = 0.09; I² = 0%). Among the animal studies, there were 4 reports of penile reconstruction, 7 studies of bladder reconstruction, and 1 study of urethroplasty. Bladder reconstruction and urethroplasty were successful in 83 and 20% of the animals, respectively. The pooled result of the stimulated intracorporeal pressure 5 V significantly favored pericardial grafts during penile reconstruction (RR 2.61, 95% CI 1.26–3.97, p = 0.0002; I² = 0%). Conclusions: Our systematic review demonstrates the feasibility of the pericardium, regardless of its type, in urologic surgeries. It, however, seems that urethral substitution needs further investigation. Given the lower cost, easier handling, and less immunogenicity of the pericardium, further studies are required to examine its pros and cons.

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“…Gastrointestinal segments are used mostly in these bladder reconstruction procedures [5]; however, incorporation of these tissues into urinary systems can cause several complications such as urolithiasis, metabolic disturbances, increased mucous production, and malignant disease [6]. These problems have led to advanced research into bladder tissue engineering [7].…”

Section: Introductionmentioning

confidence: 99%

“…Biomaterials in the bladder tissue engineering are biological materials, such as acellular tissue matrices [10,11], derived from natural sources or synthetic polymers, such as polycaprolacton (PCL) [7,12], using various fabrication techniques such as electrospinning, solvent casting, particulate leaching, 3D printing, gas foaming, phase separation, and freeze drying [9,[13][14][15][16]. Incorporation of both biological and synthetic materials along with the goal of reinforcing matrices' mechanical properties and optimizing biological properties has been proposed in previous studies [12].…”

Section: Introductionmentioning

confidence: 99%

Mechanical reinforcement of urinary bladder matrix by electrospun polycaprolactone nanofibers

et al. 2017

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Abstract. For a successful repair and reconstruction of bladder tissue, fabrication of sca olds with proper biochemical and biomechanical characteristics is necessary. Decellularized bladder tissue has been proposed in previous studies as a gold standard material for sca old fabrication. However, weak mechanical properties of such a loadbearing tissue has remained a challenge. Incorporation of both biological and synthetic materials has been known as an e ective strategy for improving mechanical and biological properties of the sca olds. In the present work, a simple process was developed to fabricate hybrid hydrogel sca olds with a biomimetic architecture from the natural urinary bladder extracellular matrix (ECM) and synthetic polycaprolactone (PCL) nano bers in order to obtain a sca old with optimized mechanical and biological properties for bladder tissue engineering. To this end, the ECM gel was derived from rat bladder, and the electrospun PCL nano bers were embedded within the gel, followed by incubating the composite to shape the hybrid hydrogel. These reinforced sca olds showed more structural integrity and mechanical stability. The introduced concept of nano ber-reinforced ECM can be applied as a promising platform in engineering of bladder or other load-bearing soft tissues.

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Bladder tissue engineering: A literature review

Cited by 45 publications

References 75 publications

Migration pathways of sacral neural crest during development of lower urogenital tract innervation

Migration pathways of sacral neural crest during development of lower urogenital tract innervation

Pericardium in Reconstructive Urologic Surgeries: A Systematic Review and Meta-Analysis

Mechanical reinforcement of urinary bladder matrix by electrospun polycaprolactone nanofibers

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