Entropy generation in unsteady magneto-bioconvection Casson nanofluid flow with gyrotactic microorganisms in the presence of Cattaneo-Christov heat and mass flux theory is analyzed. Buongiorno nanofluid model is followed taken into account the influences of viscous dissipation, Brownian motion, and thermophoresis. Mathematica is used to compute the transformed equations through homotopy analysis method (HAM) resulting from the implementation of similar-