At the present time of political and war conflicts between countries, more and more attention is focused on the protection of important structures, being part of critical infrastructure, such as buildings of energy importance, government buildings or military bases. Regardless of the type of industry area, primarily, buildings needed to be protected. For this reason, the paper is focused on the determination of resistance of selected structural elements creating the protection system against the effects of the blast from the explosion, including terrorist attack. The paper has need of analysing the behaviour of structural elements affected by the blast load and setting the structural resistance of elements loaded by such dynamic type of load. The outputs can serve as a basis for the design of an effective plan for the protection of a selected elements of critical infrastructure, which ultimately represents not only the protection of the buildings themselves, but also the affected people presented inside the buildings.