Blastic plasmacytoid dendritic cell neoplasm presenting as a renal mass

Prematilleke, I.; Mohan, Vivek; Roberts, Ian; Protheroe, Andrew; Gatter, Kevin C.

doi:10.1111/j.1365-2559.2011.03953.x

Cited by 6 publications

(4 citation statements)

References 4 publications

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“…Lack of cutaneous involvment is rare 20–22 . Atypical presentation has been described, with some patients presenting with early liver metastasis 23 or with a renal mass 24 . The present report describes the first case of BPDCN presenting with a breast nodule (patient 4).…”

Section: Discussionmentioning

confidence: 74%

“…[20][21][22] Atypical presentation has been described, with some patients presenting with early liver metastasis 23 or with a renal mass. 24 The present report describes the first case of BPDCN presenting with a breast nodule (patient 4). Bone marrow aspiration and ⁄ or biopsy may show atypical blast cells, rarely characteristic of a particular haematopoietic lineage.…”

Section: Discussionmentioning

confidence: 86%

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Blastic plasmacytoid dendritic cell neoplasm: a report of four cases and review of the literature

Borchiellini¹,

Ghibaudo

Mounier³

et al. 2012

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 86%

Blastic plasmacytoid dendritic cell neoplasm: a report of four cases and review of the literature

Borchiellini¹,

Ghibaudo

Mounier³

et al. 2012

Acad Dermatol Venereol

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“…Approximately 85% of the reported cases demonstrated cutaneous involvement at presentation, whereas a lack of cutaneous involvement is rare, with approximately 30 cases that have been reported [4,5]. Atypical presentation has been described; some patients presented with early liver metastasis [6] or with a renal mass [7].…”

Section: Discussionmentioning

confidence: 99%

Blastic plasmacytoid dendritic cell neoplasm of the skin associated with myelodysplastic syndrome

Kong¹,

Zhang²,

Sang

et al. 2015

Dermatology Online Journal

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“…This neoplasm usually presents as a cutaneous lesion, bone marrow involvement, or leukemic dissemination. Extramedullary involvement of lymph nodes, liver, spleen, kidney, breast, and central nervous system have been reported 4‐9 . Diagnosis of the disease relies on morphology, immunohistochemistry stain and flow cytometry.…”

Section: Introductionmentioning

confidence: 99%

Cytologic features of blastic plasmacytoid dendritic cell neoplasm involving liver: A case report and literature review

Ding

Yang

Lindsey

2020

Diagnostic Cytopathology

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Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare but clinically aggressive hematologic malignancy, believed to originate from plasmacytoid dendritic cells (PDCs) although it possesses multilineage potentials. Due to the dismal prognosis, accurate and rapid diagnosis is critical for early management. The disease usually initially involves skin and bone marrow. Here we report the cytopathologic findings in a case of BPDCN involving the liver in a patient previously diagnosed with BPDCN from skin and lymph node biopsies. The fine‐needle aspiration specimen from the liver lesion demonstrates a hypercellular smear of atypical epithelioid cells dispersed singly or in loose groups. These cells have enlarged, eccentric, round to irregular nuclei with fine chromatin. The agranular gray‐blue cytoplasm shows delicate wispy cytoplasmic extensions and cytoplasmic microvacuoles. Binucleation is common. The concurrent core biopsy shows that the neoplastic plasmacytoid cells with eccentric nuclei were positive for CD4, CD7, CD43, CD56, and CD68, confirming the diagnosis of BPDCN. Mutations of ASXL1 and TET2, classic for BPDCN, and a complex karyotype were detected in skin, bone marrow, and lymph node specimens. We catalog the heterogeneous pathologic features of this rare disease, emphasizing the clinical and histopathological correlation. The differential diagnoses and review of literature are also included. Awareness of this disease and accurate diagnosis are emphasized to aid early management and potentially produce a better clinical outcome.

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Blastic plasmacytoid dendritic cell neoplasm presenting as a renal mass

Cited by 6 publications

References 4 publications

Blastic plasmacytoid dendritic cell neoplasm: a report of four cases and review of the literature

Blastic plasmacytoid dendritic cell neoplasm: a report of four cases and review of the literature

Blastic plasmacytoid dendritic cell neoplasm of the skin associated with myelodysplastic syndrome

Cytologic features of blastic plasmacytoid dendritic cell neoplasm involving liver: A case report and literature review

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