Blastic plasmacytoid dendritic cell neoplasm: Case report and literature overview

Kolerova, Anastasiia; Сергеева, И.Г.; Krinitsyna, Julia; Пронкина, Н. В.; Sizikova, S. A.; Филимонов, П. Н.; Kryuchkova, I. V.

doi:10.4103/ijd.ijd_235_18

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…The rash could be itchy, painful, or asymptomatic. [ 2 ] Immunohistochemical analysis is usually helpful for diagnosing BPDCN. The co-expression of CD4, CD56, and one or more of plasmacytoid dendritic cell–specific markers (CD123, TdT, BDCA2, TCL1, CD138, CD68, Bcl2, etc.)…”

Section: Discussionmentioning

confidence: 99%

Erythematous and Bruise-Like Plaques on an 85-Year-Old Man

Lin

2023

Indian Journal of Dermatology

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Section: Discussionmentioning

confidence: 99%

Erythematous and Bruise-Like Plaques on an 85-Year-Old Man

Lin

2023

Indian Journal of Dermatology

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“…BPDCN involves multiple sites and organs, with the highest preference for skin (in 64-100% cases), followed by bone marrow and peripheral blood (80-90% cases), lymph node (40-50% cases), and spleen (20% cases) [4]. Less frequently, it was also shown to afect breast, brain and central nervous system, liver, lung, paranasal sinus, testis, and other sites [1,[5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm Occurred in Postchemotherapy of Breast Cancer

Tong

Aksenov

Siegel

et al. 2023

Case Reports in Hematology

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Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive hematologic malignancy that arises from plasmacytoid dendritic cells. BPDCN typically presents with skin lesions and may involve peripheral blood, bone marrow, lymph nodes, or extranodal sites. It usually arises de novo, and some BPDCN cases are associated with or develop into myeloid neoplasms. Here, we report a case of a 57-year-old female presenting with cervical lymphadenopathy and skin rashes during the COVID-19 pandemic in 2021 following multiple types of postmastectomy therapy for breast cancer. The patient was ultimately diagnosed with BPCDN by lymph node biopsy. To the best of our knowledge, this is the first case report of BPDCN occurring postchemotherapy of breast cancer.

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Blastic plasmacytoid dendritic cell neoplasm: Two case reports

Ma,

Sun,

et al. 2024

World J Clin Oncol

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BACKGROUND Blastic plasmacytoid dendritic cell tumor (BPDCN) is a rare and highly invasive lymphohematopoietic tumor that originates from plasmacytoid dendritic cells. BPDCN has an extremely poor prognosis. Skin lesions are usually the first manifestation of BPDCN, although the tumor may also invade the bone marrow, lymph nodes, peripheral blood, and other parts of the body, leading to several other manifestations, requiring further differentiation through skin biopsy and immunohistochemistry. CASE SUMMARY In the present paper, the cases of 2 patients diagnosed with BPDCN are discussed. The immunohistochemistry analysis of these 2 patients revealed positivity for CD4, CD56, and CD123. Currently, no standard chemotherapy regimen is available for BPDCN. Therefore, intensive therapy for acute lymphoblastic leukemia was applied as the treatment method for these 2 cases. CONCLUSION Although allogeneic bone marrow transplantation could be further effective in prolonging the median survival the ultimate prognosis was unfavorable. Future treatment modalities tailored for elderly patients will help prolong survival.

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Blastic plasmacytoid dendritic cell neoplasm: Case report and literature overview

Cited by 3 publications

References 14 publications

Erythematous and Bruise-Like Plaques on an 85-Year-Old Man

Erythematous and Bruise-Like Plaques on an 85-Year-Old Man

A Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm Occurred in Postchemotherapy of Breast Cancer

Blastic plasmacytoid dendritic cell neoplasm: Two case reports

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