Blastic Plasmacytoid Dendritic Cell Neoplasm Evaluated by FDG PET/CT

Li, Zu-Gui; Mu, Hai-Yu

doi:10.1097/rlu.0000000000001665

Cited by 4 publications

(6 citation statements)

References 15 publications

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“…On the axial images of PET, CT and PET/CT fusion, enlarged lymph nodes were observed in mediastinum (B,C), and abdominal and pelvic cavity (D,E) (arrows), which demonstrated intense 18 F-FDG uptake with the highest SUVmax of 13.9 in the mesenteric lymph node. node, bone marrow, and other organs, which is related to prognosis of the disease (5,17).…”

Section: Discussionmentioning

confidence: 99%

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18F-FDG PET/CT findings in a patient with blastic plasmacytoid dendritic cell neoplasm and post-transplant lymphoproliferative disorder after hematopoietic stem cell transplantation: a case report

Chen,

Zhang,

et al. 2023

Front. Med.

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BackgroundBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is an extremely rare hematopoietic malignancy, which originating from precursors of plasmacytoid dendritic cells. Allogeneic hematopoietic stem cell transplantation (HSCT) is normally considered in the treatment of BPDCN patients to acquire sustained remission. Post-transplant lymphoproliferative disorder (PTLD) is a group of conditions involving abnormal lymphoid cells proliferation in the context of extrinsic immunosuppression after solid organ transplantation (SOT) or HSCT. Herein, we report a patient with BPDCN, who suffered from PTLD after allogeneic HSCT.Case presentationA 66-year-old man was diagnosed with BPDCN, confirmed by pathologic examination after splenectomy. The post-surgery 18F-fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (18F-FDG PET/CT) showed multifocal 18F-FDG avidity in the left cheek, lymph nodes and bone marrow. The patient started chemotherapy, followed by allogeneic HSCT and immunosuppressive therapy. Four months after the HSCT, the patient developed intermittent fever and recurrent lymphadenopathy, accompanied with progressively elevated Epstein–Barr virus (EBV)-DNA both in serum and lymphocytes. 18F-FDG PET/CT was performed again and found multiple new enlarged 18F-FDG-avid lymph nodes, while the previous hypermetabolic lesions all disappeared. The pathology of mesenteric lymph node indicated a monomorphic PTLD (diffuse large B-cell lymphoma). Then the immunosuppressive medications were stopped and two cycles of Rituximab were given, and the follow-up CT scan indicated a complete response.ConclusionWhen patients with BPDCN recurred new enlarged lymph nodes after allogeneic HSCT and immunosuppressive therapy, PTLD should be taken into consideration. 18F-FDG PET/CT may provide additional evidence for supporting or refuting the suspicion of PTLD, and suggest lesions accessible for biopsy.

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Section: Discussionmentioning

confidence: 99%

“…The diagnosis of BPDCN is mainly based on histology, immunohistochemistry, and flow cytometry (3,4). 18 F-fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography ( 18 F-FDG PET/CT) is helpful in staging of BPDCN (5). Given the highly aggressive clinical behavior, the overall prognosis of BPDCN is poor (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

18F-FDG PET/CT findings in a patient with blastic plasmacytoid dendritic cell neoplasm and post-transplant lymphoproliferative disorder after hematopoietic stem cell transplantation: a case report

Chen,

Zhang,

et al. 2023

Front. Med.

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“…CT has been mainly used to assess the extent and depth of the skin lesions, as well as the metastases in patients with BPDCN [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] . CT shows round and ovoid homogeneous cutaneous mass with soft tissue density with or without subcutaneous invasion as seen in the present case.…”

Section: Discussionmentioning

confidence: 99%

“…Rapid progression to the terminal leukemic phase is common, resulting in a short mean survival of 12–16 months [3] . To our knowledge, there have been at least 11 reports with CT findings [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , including 4 18 F- fluorodeoxyglucose positron emission tomography / CT ( 18 F-FDG PET/CT) reports, associated with BPDCN; however, knowledge of chronological changes on sequential CT examinations have been limited [ 13 , 14 ]. We herein report a case of a patient with rapidly progressing BPDCN with a sequential evaluation on CT.…”

Section: Introductionmentioning

confidence: 99%

Rapidly progressing blastic plasmacytoid dendritic cell neoplasm causing diffuse skin thickening: A case report with sequential computed tomography examinations

Yoshioka

Kurokawa

Amemiya

et al. 2021

Radiology Case Reports

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Blastic plasmacytoid dendritic cell neoplasm is a rare aggressive myeloid malignancy thought to be derived from precursor plasmacytoid dendritic cells. Rapid progression and poor prognosis have been known. We herein present a case of BPDCN in a previously healthy man who presented with suddenly developed multiple deep purple skin rashes, with sequential computed tomography examinations. The follow-up computed tomography demonstrated that multiple skin nodules observed in the initial MRI fused, resulting in a thickening of the entire skin, with some surface erosions and crusting. Blastic plasmacytoid dendritic cell neoplasm should be considered in the differentials in patients with a sudden onset and rapidly progressing skin rash or thickening.

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“…FDG PET-CT monitoring was performed on a male with prostatic hyperplasia. FDG PET showed several slight FDG-like skin lesions in chest and back, involving left inguinal lymph nodes, and obvious FDG-like subcutaneous mass in left calf [7]. Sauerland thinks that the statement that "PET is better than tomography" is too optimistic and needs further and more reliable tests to confirm [8].…”

Section: Introductionmentioning

confidence: 99%

Application of PET-CT in Medical Diagnosis of Thyroid Tumor

2020

IJPHPM

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Thyroid tumors are divided into benign and malignant tumors, which are usually found in physical examination without any clinical manifestations in the early stage. When the tumor increases, it can compress the trachea, esophagus, recurrent laryngeal nerve, etc. The correct diagnosis rate of thyroid tumor probably determines the future cure of patients. The purpose of this article is to study the application of PET-CT in the medical diagnosis of thyroid tumors. Thyroid tumors and PET-CT were briefly introduced through literature research and investigation, and the specific application of PET-CT and common diseases causing thyroid nodules were analyzed. Specific applications of PET-CT include epilepsy localization, brain tumor characterization and recurrence judgment, early diagnosis of dementia, brain receptor research, cerebrovascular diseases, drug research, advanced health examination, lung cancer examination, etc. The effects of PET-CT and CT in the medical diagnosis of thyroid tumors were compared through comparative experiments. The results showed that for benign thyroid tumors, the diagnostic accuracy of PET-CT was 14% higher than that of CT. For malignant thyroid tumors, the diagnostic accuracy of PET-CT is 15% higher than that of CT. In addition, PET-CT diagnosis can reduce the probability of thyroid nodules being misdiagnosed as thyroid tumors.

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Blastic Plasmacytoid Dendritic Cell Neoplasm Evaluated by FDG PET/CT

Cited by 4 publications

References 15 publications

18F-FDG PET/CT findings in a patient with blastic plasmacytoid dendritic cell neoplasm and post-transplant lymphoproliferative disorder after hematopoietic stem cell transplantation: a case report

18F-FDG PET/CT findings in a patient with blastic plasmacytoid dendritic cell neoplasm and post-transplant lymphoproliferative disorder after hematopoietic stem cell transplantation: a case report

Rapidly progressing blastic plasmacytoid dendritic cell neoplasm causing diffuse skin thickening: A case report with sequential computed tomography examinations

Application of PET-CT in Medical Diagnosis of Thyroid Tumor

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