Bleaching earth clay pH 12.5/PEG-400 catalytic system for synthesis of some novel α, β-unsaturated ketones (chalcones)

Gaikwad, Milind V.; Kamble, Rahul D.; Hese, Shrikant V.; Acharya, Ashok P.; Mogle, Pratima P.; Kadam, Shuddhodan N.; Dawane, Bhaskar S.

doi:10.1007/s11164-014-1559-z

Cited by 6 publications

(3 citation statements)

References 19 publications

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“…These facts create vital interest of researcher to develop a competent method for their synthesis. As a part of our efforts for the development of green methodology for synthesis of biologically important scaffolds [37][38][39][40][41][42][43][44], herein we report microwave assisted MCR for synthesis of new 6-(4-substituted-phenyl)-3-methylimidazo[2,1-b]thiazole-2carbohydrazide derivatives.…”

Section: Methodsmentioning

confidence: 99%

Microwave assisted multicomponent reaction: An environmentally benign protocol for the synthesis of substituted imidazo[2,1-b]thiazole-2-carbohydrazide derivatives under solvent free condition

et al. 2016

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The present report describes a microwave assisted convenient and efficient protocol for the synthesis of new 6-(4-substituted-phenyl)-3-methylimidazo[2,1-b]thiazole-2-carbohydrazide derivatives. The current method holds a tag of green synthesis by virtue of catalyst and solvent free media. Moreover, the procedure offers excellent yield and purity of the products under mild condition compared with conventional method.

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Section: Methodsmentioning

confidence: 99%

Microwave assisted multicomponent reaction: An environmentally benign protocol for the synthesis of substituted imidazo[2,1-b]thiazole-2-carbohydrazide derivatives under solvent free condition

et al. 2016

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“…In the process of synthesizing chalcone, anhydrous methanol or anhydrous ethanol was used as solvents, but no satisfactory results were got. Subsequently, PEG 400 was selected as the solvent and phase transfer catalyst (Gaikwad et al, 2015), the reaction was completed in 4-5 hr with fewer by-products.…”

Section: Chemistrymentioning

confidence: 99%

Nitrogen‐containing flavonoid and their analogs with diverse B‐ring in acetylcholinesterase and butyrylcholinesterase inhibition

Chen

Liu

et al. 2020

Drug Development Research

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In this study, a series of new flavones (2-phenyl-chromone), 2-naphthyl chromone, 2-anthryl-chromone, or 2-biphenyl-chromone derivatives containing 6 or 7-substituted tertiary amine side chain were designed, synthesized, and evaluated in acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition. The results indicated that the alteration of aromatic ring connecting to chromone scaffold brings about a significant impact on biological activity. Compared with flavones, the inhibitory activity of 2-naphthyl chromone, 2-anthryl-chromone derivatives against AChE significantly decreased, while that of 2-biphenyl chromone derivatives with 7-substituted tertiary amine side chain is better than relative flavones derivatives. For all new synthesized compounds, the position of tertiary amine side chain obviously influenced the activity of inhibiting AChE. The results above provide great worthy information for the further development of new AChE inhibitors. Among the newly synthesized compounds, compound 5a is potent in AChE inhibition (IC 50 = 1.29 ± 0.10 μmol/L) with high selectivity for AChE over BChE (selectivity ratio: 27.96). An enzyme kinetic study of compound 5a suggests that it produces a mixed-type inhibitory effect against AChE.

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“…In recent years, bleaching earth clay has emerged as a green, easily separable, ecofriendly, economical, nontoxic, and heterogeneous catalyst employed for several base-catalyzed organic transformations [33][34][35][36][37]. The small grain size of the clay renders a huge surface area compared with other solid-supported catalysts.…”

Section: Introductionmentioning

confidence: 99%

Bleaching earth clay (pH 12.5)/PEG-400: an efficient recyclable catalytic system for synthesis of 5,6,7,8-tetrahydroquinoline-3-carbonitrile derivatives

et al. 2014

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A green, efficient, and simple method for synthesis of 5,6,7,8-tetrahydroquinoline-3-carbonitrile derivatives via one-pot three-component condensation of 2,6-bis(substituted benzylidene)cyclohexanone, arylamines/substituted 2-aminothiazoles, and malononitrile in the presence of bleaching earth clay pH 12.5 (basic catalyst) as a recyclable and green catalyst in PEG-400 is described. Catalyst recyclability, good to excellent product yield, shorter reaction time, and avoidance of hazardous reagents are the main advantages of this methodology.

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Bleaching earth clay pH 12.5/PEG-400 catalytic system for synthesis of some novel α, β-unsaturated ketones (chalcones)

Cited by 6 publications

References 19 publications

Microwave assisted multicomponent reaction: An environmentally benign protocol for the synthesis of substituted imidazo[2,1-b]thiazole-2-carbohydrazide derivatives under solvent free condition

Microwave assisted multicomponent reaction: An environmentally benign protocol for the synthesis of substituted imidazo[2,1-b]thiazole-2-carbohydrazide derivatives under solvent free condition

Nitrogen‐containing flavonoid and their analogs with diverse B‐ring in acetylcholinesterase and butyrylcholinesterase inhibition

Bleaching earth clay (pH 12.5)/PEG-400: an efficient recyclable catalytic system for synthesis of 5,6,7,8-tetrahydroquinoline-3-carbonitrile derivatives

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