Bleeding manifestations in dengue and their correlation with the platelet count

Sreenivasa, B; Manjunatha, Bhari Sharanesha; Joseph, Nivil

doi:10.4038/sljch.v46i3.8320

Cited by 5 publications

(10 citation statements)

References 4 publications

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“…Sreenivas et al, found that 26% of cases had melaena, 20% had petechiae, 8% had haematemesis, 4% had epistaxis and 2% had gum bleeding. 25 Hematuria was the least common finding among our patients , accounting for about 1%, it was reported the same in the earlier studies of Sreenivasan et al, Narayanan et al, that bleeding by the urogenital tract is less common among the bleeding manifestations. 14,25 Various types of complications were seen during course of disease.…”

Section: Discussionsupporting

confidence: 83%

“…25 Hematuria was the least common finding among our patients , accounting for about 1%, it was reported the same in the earlier studies of Sreenivasan et al, Narayanan et al, that bleeding by the urogenital tract is less common among the bleeding manifestations. 14,25 Various types of complications were seen during course of disease. These were hepatopathy, acute renal failure (nephropathy), ascites, Pneumonia, dengue hemorrhagic fever(DHF), Dengue complicated with shock (DSS), multi-organ dysfunction syndrome and extended dengue syndrome.…”

Section: Discussionsupporting

confidence: 83%

“…and no bleeding was seen in patients with platelet counts of more than 1,50,000. It was observed that 95.8% of patients with platelet counts between 20,000-50,000/cu.mm developed haemorrhage according to Sreenivasa [25][26][27][28] Authors found that the percentage of patients that develop bleeding decrease with rising platelet levels.…”

Section: Discussionmentioning

confidence: 99%

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Clinical spectrum of dengue at a tertiary care hospital in Eastern India

et al. 2019

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Background: Dengue is a vector borne disease by four different serotypes of dengue virus transmitted by bite of female Aedes mosquito. It is an acute febrile illness characterised by myalgia, joint pain, gastrointestinal manifestations. Complications like dengue hemorrhagic fever (DHF) and Dengue shock syndrome (DSS) , Extended Dengue Syndrome(EDS) may be fatal for patients. Authors analyse different clinical spectrum of of manifestations, complications and correlation bleeding to platelet level.Methods: This study conducted from July 2017 to December 2018 comprising of 100 dengue patients of age more than 15 years in IMS & SUM Hospital.Result: Out of 100 dengue patients’ males 73% and females 27%. From the patients 57% were NS1 Antigen positive, 29% IgM positive, 9% NS1 and IgM positive, 4% IgM and IgG positive and 2 % with all NS1, IgM, IgG positive. In our series in clinical manifestations, all cases (100%) presented with fever, myalgia (78%), headache (53%), rashes (14%), nausea, pain abdomen (21%) loose motion (17%), and Retro-orbital pain (6%). Bleeding manifestations in any form was seen in 39% cases like Purpura or Petechie (23%), malena (18%), hematemesis ( 2% ), epixtasis (6%), Gum bleeding (2%), Hematuria (1%), and Ophthalmic bleeding like sub conjunctival hemorrhage, intra-vitreal hemorrhage in 8% cases. Complications detected e.g. hepatopathy in 53%, nephropathy. 4%, ascites 8%, pneumonia 7%, DSS (4%), Multi Organ Dysfunction (MODS) (4%), DHF (8%) and EDS in 2% cases. It was observed that 95.8% of patients with platelet counts between 20,000-50,000/cu.mm and 61% of patients less than 25000 had bleeding manifestations.Conclusion: Wide clinical spectrum of manifestations and complications makes it common differential diagnosis of acute febrile illnesses and bleeding manifestation does not always corelate with lower platelet count.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 83%

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Clinical spectrum of dengue at a tertiary care hospital in Eastern India

et al. 2019

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show abstract

Section: Discussionmentioning

confidence: 99%

“…Thrombocytopenia is usually mild, asymptomatic but may be associated with bleeding 18 along with vasculopathy, coagulopathy and platelet dysfunction. 5 It may 13,17,19 or may not correlate with severity of bleeding 15,18 and complications. 10,15 Platelet counts drop between 3 rd -7 th days, normalise by 8th-10 th days reach a nadir between 4-7 th day 5,8,11,14 coinciding with late febrile and early critical preshock period which precedes the rise in hematocrit 2,6,15 .…”

Section: Discussionmentioning

confidence: 99%

Do the small blood cells have a big impact as prognosticators in dengue – A study

Joshi¹,

Divyashree²,

Tanjore³

et al. 2020

JDPO

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Dengue is an arboviral disease endemic in India. Severe dengue has a high morbidity. The progression to severe dengue may be diagnosed by clinical and lab parameters, are of the useful lab tests is platelet count, as thrombocytopenia is a consistent feature in dengue. There is confusion about the role thrombocytopenia in dengue. Our study aims to study the platelet count patterns and its relevance to severity of dengue. Materials and Methods: We conducted a study on 132 dengue positive cases with relevant hematology data in November 2016. Results: We had predominance of young people and males in the study group. Thrombocytopenia was uniform across the ages and sexes. Severe thrombocytopenia constituted 56%, had significant association with atypical lymphocytosis, rise in hematocrit and antibody patterns. Conclusion: Platelet counts are marker of dengue, can serve as predicators of severity, platelet count monitoring helps guide transfusion therapy.

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Mean platelet volume: Has it the capacity to predict the concentration of Platelet counts in Dengue: A study

Joshi¹,

Sathyavathi²,

Gayathri³

et al. 2020

IJPO

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Dengue, endemic in India presents in mild to severe forms with or without bleeding. There is no specific treatment available till date hence severe dengue has to be recognized in early stages. Platelet counts are unreliable as they do not correlate with bleeding. Platelet indices have been studied for their utility as predictors of severity of the disease and aid in guide to transfusion therapy. Mean platelet volume is inexpensive and available with routine complete blood counts in hematology analyser. Its role as marker in diagnosis, prognosis and treatment of dengue has been investigated with platelet indices reports. To study MPV patterns, association with platelet counts and relevant laboratory parameters in dengue. The study was conducted over one month in the year 2016 in department of Hematology, Kempegowda Institute of Medical Sciences Hospital, Bengaluru. 100 serologically proven dengue cases were analysed with data collected from the records in the departments of Hematology and Microbiology against patient’s unique hospital identification number. There was a predominance of young male patients. The range for MPV was 8.7 – 13.2 (average 10.95) with 35% normal and 65% high MPV cases. There was 48% cases with moderately severe / severe thrombocytopenia. 32% with increased hematocrit, 35% with leucopenia, 54% with significant atypical lymphocytosis and 42% with antibody pattern. There was an increased number of high MPV seen in severe thrombocytopenia, increased hematocrit significant atypical lymphocytosis and antibody pattern whereas normal pattern was noted in leucopenia. High MPV is a useful predictor of severe dengue platelet recovery and may guide in transfusion therapy.

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Bleeding manifestations in dengue and their correlation with the platelet count

Cited by 5 publications

References 4 publications

Clinical spectrum of dengue at a tertiary care hospital in Eastern India

Clinical spectrum of dengue at a tertiary care hospital in Eastern India

Do the small blood cells have a big impact as prognosticators in dengue – A study

Mean platelet volume: Has it the capacity to predict the concentration of Platelet counts in Dengue: A study

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