Bleeding Time and Scoliosis

Udén, Alf; Nilsson, Inga Marie; Willner, Stig

doi:10.3109/17453678208992182

Cited by 6 publications

(7 citation statements)

References 16 publications

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“…31,32 The bleed ing time may decrease with age [33][34][35][36][37] and tends to be longer among females than males. 35,[38][39][40] Pregnancy tends to shorten the test in patients with von Willebrand's syndrome; 41 the effect of pregnancy has not been exam ined in healthy subjects. Other factors that may influence the test include: handedness, 25 serum triglycerides, the weight to height ratio, skin fold thickness, and social class.…”

Section: Survey Of the Literaturementioning

confidence: 99%

“…Abnormal bleeding times have been reported in a variety of disorders not thought of as primarily platelet-related (the degree to which these disorders may prolong the bleeding time on the basis of altered platelet count, mass, or efficacy is not estab lished). The list of diseases includes amyloidosis; 139 Barrier's syndrome; 140 glycogen storage disease type I; 141 congenital heart disease; 73,97,142,143 diseases af fecting tissue integrity, such as scoliosis 35,144,145 and collagen defects 146 (including osteogenesis imperfecta 147,148 and Ehlers-Danlos syndrome 149 ); neurofibromatosis, 3 dysfibrinogenemia; 150 defi ciencies of fibrinogen [151][152][153] or coagulation Factors V, [154][155][156][157] VII, [158][159][160][161] VIII, 5,22,98,157,[162][163][164][165][166][167][168][169][170][171] IX, 98,157,166,168,169,[172]…”

Section: The Bleeding Time Is Not a Specific In Vivo Indicator Of Plamentioning

confidence: 99%

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A Critical Reappraisal of the Bleeding Time*

Rodgers¹,

Levin²

1990

Semin Thromb Hemost

612

292

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Since its initial invention by the French worker Milian in 1901, the bleeding time has been put forward as a clinically useful test in three contexts: diagnosis (particularly of platelet disorders), prediction of clinically important bleeding, and assessment of the adequacy of various forms of therapy. Attempting a complete review of the published experience with this test, we assessed 862 articles. Original bleeding time data appeared in 664 of these articles, from which we tabulated 1083 distinct studies in humans. ROC analysis, which characterizes the sensitivity and specificity of the test, was applied in every instance in which published data were adequate (34 studies). ROCs from 27 studies of the bleeding time in association with aspirin ingestion reveal high variability in the ability of the bleeding time to detect aspirin intake, and provide evidence against claims that recently devised bleeding time methods have improved discriminatory ability based on improved reproducibility. Two ROCs from surgical studies, in which the bleeding time was used to try to predict abnormal bleeding, were statistically indistinguishable from that of a completely noninformative test. In ROCs from five studies of abnormal bleeding in uremia, the test performed approximately the same as the platelet count or hematocrit (taken singly); in one of these studies, prothrombin consumption was determined and was a better predictor of bleeding than bleeding time, hematocrit, or platelet count. In the settings of renal biopsy (one study) and massive transfusion (one study), data allowed estimation of predictive value: in no instance was there evidence that the bleeding time significantly altered a priori estimates (based on prevalence) of the risk of bleeding. Linear regression analysis was applied to data from 23 studies relating platelet count to bleeding time, to assess published claims that the bleeding time and platelet count follow a predictively useful linear relationship. In 22 of 23 instances, the inverse relationship between bleeding time and platelet count was associated with broad statistical scatter, making it impossible to predict precisely one variable given the other. The pathophysiology of an abnormal bleeding time remains poorly understood. The bleeding time is affected by a large number of diseases, drugs, physiologic factors, test conditions, and therapeutic actions, not all of them platelet-related. The test is likely to remain widely used for the diagnosis of inherited disorders of platelet function, such as von Willebrand's syndrome, despite the lack of clear criteria for its use in this context.(ABSTRACT TRUNCATED AT 400 WORDS)

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Section: Survey Of the Literaturementioning

confidence: 99%

Section: The Bleeding Time Is Not a Specific In Vivo Indicator Of Plamentioning

confidence: 99%

A Critical Reappraisal of the Bleeding Time*

Rodgers¹,

Levin²

1990

Semin Thromb Hemost

612

292

View full text Add to dashboard Cite

show abstract

“…Abnormal bleeding times have been reported in a variety of disorders not thought of as primarily platelet-related (the degree to which these disorders may prolong the bleeding time on the basis of altered platelet count, mass, or efficacy is not established). The list of diseases includes amyloidosis 139 ; Barrier's syndrome 140 ; glycogen storage disease type I 141 ; congenital heart disease 73 97 142 143 ; diseases affecting tissue integrity, such as scoliosis 35 144 145 and collagen defects 146 (including osteogenesis imperfecta 147 148 and Ehlers-Danlos syndrome 149 ); neurofibromatosis, 3 dysfibrinogenemia 150 ; deficiencies of fibrinogen 151 152 153 or coagulation factors V, 154 155 156 157 VII, 158 159 160 161 VIII, 5 22 98 157 162 163 164 165 166 167 168 169 170 171 IX, 98 157 166 168 169 172 173 174 175 176 177 178 X, 179 180 181 XI, 166 175 179 182 183 184 185 or XII 157 ; the presence of factor VIII inhibitors…”

Section: Discussionmentioning

confidence: 99%

“…31,32 The bleeding time may decrease with age [33][34][35][36][37] and tends to be longer among females than in males. 35,[38][39][40] Pregnancy tends to shorten the test in patients with von Willebrand's syndrome 41 ; the effect of pregnancy has not been examined in healthy subjects. Other factors that may influence the test include handedness, 25 serum triglycerides, the weight to height ratio, skin fold thickness, and social class.…”

Section: Survey Of the Literaturementioning

confidence: 99%

“…30 These differences may be due to dietary habits, as suggested by studies in which the ingestion of fish oil appeared to decrease the bleeding time. 31,32 The bleeding time may decrease with age [33][34][35][36][37] and tends to be longer among females than in males. 35,[38][39][40] Pregnancy tends to shorten the test in patients with von Willebrand's syndrome 41 ; the effect of pregnancy has not been examined in healthy subjects.…”

Section: Survey Of the Literaturementioning

confidence: 99%

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A Critical Reappraisal of the Bleeding Time

Rodgers,

Levin

2023

Semin Thromb Hemost

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Seminars in Thrombosis and Hemostasis (STH) celebrates 50 years of publishing in 2024. To celebrate this landmark event, STH is republishing some archival material. This manuscript represents the second most highly cited paper ever published in STH. The manuscript published without an abstract, and essentially represented a State of the Art Review on the bleeding time, a relatively invasive procedure that required an incision on the skin or earlobe of a patient, and timing how long it took for the incision to stop bleeding. The bleeding time test was first described in 1901 by the French physician Milian, who presented three studies of bleeding from stab wounds made in the fingertips of healthy and diseased subjects. In 1910, Duke observed the duration of bleeding from small incisions of the ear lobe, and pointed out that the duration of bleeding was increased in instances of reduced platelet counts. The test was subsequently repeatedly modified, and numerous variants of the test, including semiautomated methods, were described by several workers. The most frequently utilised test reflected one described by Ivy and coworkers, who shifted the location of the incision to the volar aspect of the forearm and applied a blood pressure cuff to the arm to maintain a standard venous pressure. The bleeding time has been proposed for use as a diagnostic test for platelet-related bleeding disorders, a measure of efficacy in various forms of therapy, and as a prognosticator of abnormal bleeding. The authors to the current review reevaluated the bleeding time literature using methods to assess the performance of the test in 1990, locating 862 printed documents that discussed the bleeding time, the majority in peer-reviewed professional journals. As this is a republication of archival material, transformed into a modern format, we apologise in advance for any errors introduced during this transformation.

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Prolonged bleeding time

Lind¹

1984

The American Journal of Medicine

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Bleeding Time and Scoliosis

Cited by 6 publications

References 16 publications

A Critical Reappraisal of the Bleeding Time*

A Critical Reappraisal of the Bleeding Time*

A Critical Reappraisal of the Bleeding Time

Prolonged bleeding time

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